DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and ELFN1

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001122108.1	Gene:	ELFN1 / 392617	HGNCID:	33154	Length:	828	Species:	Homo sapiens

Alignment Length:	835	Identity:	161/835 - (19%)
Similarity:	272/835 - (32%)	Gaps:	240/835 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IWCILASIGVEPAAGLANCPPGCQCDDNTLV--VQCGEGQ--LDVLPIALNPSIQRLVIKSNKIK 72
            :|..:|:..:..|.|||.........|...|  ..|.:.|  .:.:|..:|.:|..|.:..|:|:
Human     9 LWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLRLNENRIR 73

  Fly    73 TID-SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLN 136
            ::. :|:..:..||:|:|:.|.:..|....|:.|..||.:.|.:|::..::.....||..:..|.
Human    74 SVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLGKLEYLY 138

  Fly   137 LRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQA 201
            |:.|.|..:...:|.....|..::|..|||..|:...|.||::|.:..|..|......:.:.|
Human   139 LQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLAKLSVCELYSNPFYCSCELLGF-- 201

  Fly   202 MPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRI 266
            :..||.......|...:|.::.....|   ..|.|...|  .|.|.  |.:|:.:...|:....:
Human   202 LRWLAAFTNATQTYDRMQCESPPVYSG---YYLLGQGRR--GHRSI--LSKLQSVCTEDSYAAEV 259

  Fly   267 -----PSVGLSKLVRL-------EQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGA 319
                 |:.|.|:..|.       |...:...|.|..|......|..|..|......|
Human   260 VGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGTTPLVALPTLATQAEAR-------- 316

  Fly   320 FSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLD-LSENP 383
                            .|::|::             |..|:.|...:...|:..:.||: .:.:.
Human   317 ----------------PLIKVKQ-------------LTQNSATITVQLPSPFHRMYTLEHFNNSK 352

  Fly   384 LSCDCRV------MWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQA 442
            .|...|:      :.|.||....|.:...||          ....|||.:..:..|.   ||..:
Human   353 ASTVSRLTKAQEEIRLTNLFTLTNYTYCVVS----------TSAGLRHNHTCLTICL---PRLPS 404

  Fly   443 LIGALLVGSAAT---------ITALALVL---YRCRHKIRETIKGGLWGNSALGRKEREYQKTFC 495
            ..|.:...|.||         :..:.|||   |.|..:.|              |:|.:::|.
Human   405 PPGPVPSPSTATHYIMTILGCLFGMVLVLGAVYYCLRRRR--------------RQEEKHKKA-- 453

  Fly   496 DEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTAT 560
                        .|.....:...|.....:.......|:.|:....|  :.|:...:...:|.|.
Human   454 ------------ASAAAAGSLKKTIIELKYGPELEAPGLAPLSQGPL--LGPEAVTRIPYLPAAG 504

  Fly   561 MISEKKL----NNNKALVSQGAI--------------------DDSASFVLHMKSATMGRDVHQQ 601
            .:.:.||    :..||  |:|:.                    .||.|.|..:  :|:.::|.:.
Human   505 EVEQYKLVESADTPKA--SKGSYMEVRTGDPPERRDCELGRPGPDSQSSVAEI--STIAKEVDKV 565

  Fly   602 NPQLNHYTKPQFLSATATVG--DSCYSYADVPMV----------------------------HGA 636
            |..:|:........:|:..|  ....|.|:.|:|                            |..
Human   566 NQIINNCIDALKSESTSFQGVKSGPVSVAEPPLVLLSEPLAAKHGFLAPGYKDAFGHSLQRHHSV 630

  Fly   637 PLGGP-----------NQPQ------------------------------LRLTQEHFKQRELYD 660
            ...||           ..|:                              |.:|......|.  :
Human   631 EAAGPPRASTSSSGSVRSPRAFRAEAVGVHKAAAAEAKYIEKGSPAADAILTVTPAAAVLRA--E 693

  Fly   661 QEMGSEILDHNYIYSNTHYSMPLEQLGRSKTPTPPPMPPALPLRNGLCATTGRRS 715
            .|.|.:..:|.:.|..:|   |.|       |..||.||..|...||    ||::
Human   694 AEKGRQYGEHRHSYPGSH---PAE-------PPAPPGPPPPPPHEGL----GRKA 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/18 (22%)
		LRR_8	83..142	CDD:290566	17/58 (29%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	60/310 (19%)
		LRR_8	132..190	CDD:290566	17/57 (30%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	4/23 (17%)
		LRR_8	203..263	CDD:290566	13/59 (22%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..308	CDD:290566	13/67 (19%)
		leucine-rich repeat	253..276	CDD:275380	5/27 (19%)
		leucine-rich repeat	277..300	CDD:275380	5/29 (17%)
		leucine-rich repeat	301..322	CDD:275380	3/20 (15%)
		LRR_8	325..384	CDD:290566	8/59 (14%)
		leucine-rich repeat	326..350	CDD:275380	2/23 (9%)
		leucine-rich repeat	351..373	CDD:275380	4/21 (19%)
ELFN1	NP_001122108.1	LRR 1	61..82		5/20 (25%)
		leucine-rich repeat	65..85	CDD:275378	4/19 (21%)
		LRR_8	85..144	CDD:404697	17/58 (29%)
		LRR 2	85..106		7/20 (35%)
		leucine-rich repeat	86..109	CDD:275378	8/22 (36%)
		LRR 3	109..130		4/20 (20%)
		leucine-rich repeat	110..133	CDD:275378	6/22 (27%)
		LRR 4	133..154		5/20 (25%)
		leucine-rich repeat	134..157	CDD:275378	5/22 (23%)
		LRR 5	157..178		7/20 (35%)
		leucine-rich repeat	158..171	CDD:275378	5/12 (42%)
		PCC	162..>256	CDD:188093	25/102 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..291		5/31 (16%)
		LRR 6	318..342		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..552		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..649		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..732		14/49 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010