DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lrrc24

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_932787.1	Gene:	Lrrc24 / 378937	MGIID:	3605040	Length:	521	Species:	Mus musculus

Alignment Length:	576	Identity:	120/576 - (20%)
Similarity:	190/576 - (32%)	Gaps:	219/576 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MMIAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSN 69
            :::..:|:..:....|:.|.|  ..||..|:|...|  |:||..:|.|:|..:.|..|.|.
Mouse     8 LLLLLLGLLLLPLLPGLPPRA--TGCPAACRCYSAT--VECGALRLRVVPPGIPPGTQTLF---- 64

  Fly    70 KIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTV 134

Mouse    65 ----------------------------------------------------------------- 64

  Fly   135 LNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIF 199
              |:.|.|:.|.||:..|                        |:.||.|||.:
Mouse    65 --LQDNSIAHLEQGSLAP------------------------LAALRHLYLHN------------ 91

  Fly   200 QAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLD 264
                         |||:::::.||:....|..|.|.|..||.:...:|:||.:||:|.|:.|:|.
Mouse    92 -------------NTLRALESGAFRAQPRLLELALTGNRLRGLRGGAFVGLVQLRVLYLAGNQLA 143

  Fly   265 RIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYL 329
            ::.......|.||::|.|.:|..|::.:.|..||                         .:|..|
Mouse   144 KLLDFTFLHLPRLQELHLQENSIELLEDQALAGL-------------------------SSLALL 183

  Fly   330 NLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWL- 393
            :||.|::      |.:|                  .|.|.|...||.|.|:|||..|||.:.||
Mouse   184 DLSRNQL------GTIS------------------KEALQPLSSLQVLRLTENPWRCDCALHWLG 224

  Fly   394 -------HNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHAD-----PRKQALIGA 446
                   ..||    :|:|  .::.|..|.||..:||..::...:.|....     |...|.:|.
Mouse   225 SWIKEGGRRLL----SSRD--KKITCAEPPRLALQSLLEVSGGSLICIPPSVNVEPPEFTANLGE 283

  Fly   447 -LLVGSAATITALALVLYR-------CRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRH 503
             |.|...|:.....||::|       .:.:.:..::||..|....|.::......|.....::..
Mouse   284 DLQVACQASGYPQPLVVWRKVPQPRDGKPQAQAQLEGGAPGLGGHGTRDTGSGMLFLTNITLAHA 348

  Fly   504 QHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTA 559
            ..:.|.                  |.:..|...:|.:.|.....||. |||..|.|
Mouse   349 GKYECE------------------AANAGGKARVPFHLLVNASRQQS-QQLPDPQA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	2/58 (3%)
		leucine-rich repeat	84..107	CDD:275380	0/22 (0%)
		leucine-rich repeat	108..131	CDD:275380	0/22 (0%)
		LRR_RI	129..421	CDD:238064	73/299 (24%)
		LRR_8	132..190	CDD:290566	13/57 (23%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	1/22 (5%)
		leucine-rich repeat	180..204	CDD:275380	5/23 (22%)
		LRR_8	203..263	CDD:290566	19/59 (32%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..308	CDD:290566	16/55 (29%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	0/20 (0%)
		LRR_8	325..384	CDD:290566	16/58 (28%)
		leucine-rich repeat	326..350	CDD:275380	7/23 (30%)
		leucine-rich repeat	351..373	CDD:275380	3/21 (14%)
Lrrc24	NP_932787.1	LRR_8	48..92	CDD:290566	19/163 (12%)
		LRR 1	59..80		8/91 (9%)
		LRR_RI	<60..>166	CDD:238064	41/225 (18%)
		leucine-rich repeat	61..83	CDD:275380	10/116 (9%)
		LRR 2	83..104		10/45 (22%)
		LRR_8	84..142	CDD:290566	24/82 (29%)
		leucine-rich repeat	84..107	CDD:275380	10/47 (21%)
		LRR 3	107..128		7/20 (35%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_8	131..213	CDD:290566	31/130 (24%)
		LRR_4	131..171	CDD:289563	13/39 (33%)
		LRR 4	131..152		6/20 (30%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		LRR 5	155..176		7/20 (35%)
		leucine-rich repeat	156..179	CDD:275380	8/47 (17%)
		LRR 6	179..200		9/44 (20%)
		leucine-rich repeat	180..203	CDD:275380	10/46 (22%)
		LRRCT	212..265	CDD:214507	17/58 (29%)
		Ig	267..361	CDD:299845	16/111 (14%)
		IG_like	274..370	CDD:214653	18/113 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..330		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..395		7/13 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100