DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Toll-7

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	148/574 - (25%)
Similarity:	215/574 - (37%)	Gaps:	184/574 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LANCPPGCQCDDNTLVV-------------------QCGEG------QLDVLPIALNP------- 59
            |...|.|..|....|.|                   .||.|      :|.||..:.|.
  Fly   201 LRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISES 265

  Fly    60 -------SIQRLVIKSNKIKTID-SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHN 116
                   .:|.|.:..|.:..:. .::...|.|..::||:|||.|:|:..||..|:|:|:||..|
  Fly   266 WGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQN 330

  Fly   117 KI--------------------------GQISNKTFIGL----------SAVT------------ 133
            ::                          ..:.|.||.||          :|:|
  Fly   331 ELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYF 395

  Fly   134 --VLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDP 196
              :||||.|.|..:....|.||..:..|||.|||:..||.|.|:||..|..|.|::| |.:|.:|
  Fly   396 LQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNN-LISVVEP 459

  Fly   197 VIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDN 261
            .:|:....|.||.|..|.|..:.. |.|||..|..|:|....:|...:.||..|.:|..|.|.||
  Fly   460 AVFKNCSDLKELDLSSNQLNEVPR-ALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDN 523

  Fly   262 RLDRIPSVGL-SKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKR----VMTGAFS 321
            ::..| :||: ..|.||..|:|.:|..:.|..|:|.     |..|:. |:||.|    .:.|.|:
  Fly   524 QIGNI-TVGMFQDLPRLSVLNLAKNRIQSIERGSFD-----KNFELE-AIRLDRNFLADINGVFA 581

  Fly   322 DNGNLEYLNLS------------------------------------------------------ 332
            ...:|.:||||
  Fly   582 TLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEI 646

  Fly   333 --------------SNKMLLEVQEGALSGLSQLKHVVLKANALTSL-------AEGLFPWKDLQT 376
                          :|.::..||..|....:.|..|.|.||.|:.|       |..:.| |.|..
  Fly   647 GPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAP-KPLPE 710

  Fly   377 LDLSENPLSCDCRVMWL---HNLLVAKNASQDDVSELLCEFPERLRGESLRHLN 427
            ..|..||..|||.:.||   :||...::....|::.:.|..| ..||.::|.|:
  Fly   711 FYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMP-HARGAAVRPLS 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	3/18 (17%)
		LRR_8	83..142	CDD:290566	28/108 (26%)
		leucine-rich repeat	84..107	CDD:275380	10/22 (45%)
		leucine-rich repeat	108..131	CDD:275380	10/58 (17%)
		LRR_RI	129..421	CDD:238064	108/398 (27%)
		LRR_8	132..190	CDD:290566	26/71 (37%)
		leucine-rich repeat	132..155	CDD:275380	10/36 (28%)
		leucine-rich repeat	156..179	CDD:275380	12/22 (55%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	22/59 (37%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	19/56 (34%)
		leucine-rich repeat	253..276	CDD:275380	9/23 (39%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	8/24 (33%)
		LRR_8	325..384	CDD:290566	22/133 (17%)
		leucine-rich repeat	326..350	CDD:275380	9/91 (10%)
		leucine-rich repeat	351..373	CDD:275380	9/28 (32%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	148/574 (26%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	13/57 (23%)
		leucine-rich repeat	191..214	CDD:275380	4/12 (33%)
		leucine-rich repeat	215..248	CDD:275380	5/32 (16%)
		LRR_RI	247..501	CDD:238064	73/255 (29%)
		LRR_8	247..308	CDD:290566	12/60 (20%)
		leucine-rich repeat	249..273	CDD:275380	4/23 (17%)
		leucine-rich repeat	274..297	CDD:275380	3/22 (14%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	10/22 (45%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	12/60 (20%)
		leucine-rich repeat	346..371	CDD:275380	5/24 (21%)
		leucine-rich repeat	372..395	CDD:275380	2/22 (9%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	419..478	CDD:290566	25/59 (42%)
		leucine-rich repeat	420..443	CDD:275380	12/22 (55%)
		leucine-rich repeat	444..467	CDD:275380	8/23 (35%)
		LRR_RI	466..622	CDD:238064	47/163 (29%)
		leucine-rich repeat	468..488	CDD:275380	8/20 (40%)
		LRR_8	491..549	CDD:290566	21/58 (36%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	8/21 (38%)
		leucine-rich repeat	539..562	CDD:275380	8/27 (30%)
		leucine-rich repeat	563..585	CDD:275380	6/22 (27%)
		leucine-rich repeat	586..626	CDD:275380	5/39 (13%)
		leucine-rich repeat	627..653	CDD:275380	0/25 (0%)
		LRRCT	716..772	CDD:214507	16/49 (33%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940