DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and lbk

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_611091.2 Gene:lbk / 36788 FlyBaseID:FBgn0034083 Length:1252 Species:Drosophila melanogaster


Alignment Length:793 Identity:188/793 - (23%)
Similarity:293/793 - (36%) Gaps:233/793 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 ASIGVEPAAGLA--------NCPPGCQC--------------------------------DDNTL 41
            |...:|.||..|        :||..|:|                                :|.|:
  Fly   244 AQKALEAAAAAAKASNKYNIDCPKDCKCLNVLFDCDKLHLERVPVLPSYVQTLHLANNKLNDTTV 308

  Fly    42 V----------VQCGEGQLDVLP--IALNPSIQRLVIKSNKIKTIDS-SIQFYAELTFLDLSSNH 93
            :          |......|:|:|  |.|: .::.||:.:|.|.:|.| |:.....|..||||.|.
  Fly   309 LEIRNLLNLTKVSLKRNLLEVIPKFIGLS-GLKHLVLANNHITSISSESLAALPLLRTLDLSRNK 372

  Fly    94 LMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEE 158
            |.||...:|.....|..:.|:.|:|..::..:|..|:.:|.|.|..|::|.|....|..|.::::
  Fly   373 LHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNLNQLKK 437

  Fly   159 LNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAF 223
            |.|..|:: .::...|.||..::.|.|..|.:..:.|.| |..|..:..:.|.||.:.|:.....
  Fly   438 LALNFNQL-EINWSTFRGLESMKNLQLKSNKIRALQDGV-FYVMHKIETIDLAMNQISSLSRQGL 500

  Fly   224 QDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFE 288
            .:|..|..|.|...::..|..|::...|.|.:||||:|.::......|..|.||:.|:|..|..:
  Fly   501 FNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQ 565

  Fly   289 VISEGA-----------------------------FMGLKQLKRLEVNGALRLKRVMTGAFSDNG 324
            .:.|..                             |.||::|:||:::|. .||::.|.|.|...
  Fly   566 YLQENTFDCVKNLEELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGN-NLKQISTKAMSGLN 629

  Fly   325 NLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKA-NALTSLAEGLFPWKDLQTLDLSENPLSCDC 388
            |||.|||.|| .|..:|..|...:.:|..:|.|: |.:                        |||
  Fly   630 NLEILNLGSN-ALASIQVNAFEHMLRLNKLVFKSLNFI------------------------CDC 669

  Fly   389 RVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHA-DPRKQALIGALLVGSA 452
            .::|....|  ||.........:|.:||.|....|:.|:.:.:.|..: .||.:.....:|..:|
  Fly   670 DLVWFQQWL--KNRFPQQAEHAVCGYPEHLLDRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNA 732

  Fly   453 ATIT-----------ALAL---VLYRCRH-------------------KIR---ETIKGGLWGNS 481
            |.||           :||.   :..:.||                   :||   .|.:..::|..
  Fly   733 ANITLECIASSPTAASLAAADELKIKWRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYL 797

  Fly   482 ALGRKERE----YQKTFCDEDYMSRHQHHPCSLGIHSTF---PNTYTAPHHPGATHHYGMCPMPV 539
            .|.....|    ||....:....:..|....|:|||.||   |:..|.                 
  Fly   798 RLTNVTYESAGRYQCVVSNAFGTTYAQKFKISIGIHPTFLQVPSNLTL----------------- 845

  Fly   540 NDLGAI---------DPQ-----QKFQQLVVPTAT-----MISEKK---LNNNK----------A 572
             |.|.:         ||.     |||.....|.||     :|.|:.   :.|.|          |
  Fly   846 -DAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQVIREENAFLITNAKPSDSGIYTCTA 909

  Fly   573 LVSQGAIDDSASFVLHMK-----------------------SATMGRDVHQQNPQLNHY--TKPQ 612
            |.:.|.|..:|:.|::.|                       |.|...|...::|....:  .||.
  Fly   910 LSAAGEIKVNATLVVNDKPQPSIPLVHQEVVVGRTCVLQCLSETANADFELEHPHREWFKENKPI 974

  Fly   613 FLSATATVGDSCY 625
            .:|.||..||..|
  Fly   975 HISPTAPDGDRYY 987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 7/18 (39%)
LRR_8 83..142 CDD:290566 20/58 (34%)
leucine-rich repeat 84..107 CDD:275380 10/22 (45%)
leucine-rich repeat 108..131 CDD:275380 6/22 (27%)
LRR_RI 129..421 CDD:238064 85/321 (26%)
LRR_8 132..190 CDD:290566 17/57 (30%)
leucine-rich repeat 132..155 CDD:275380 8/22 (36%)
leucine-rich repeat 156..179 CDD:275380 6/22 (27%)
leucine-rich repeat 180..204 CDD:275380 7/23 (30%)
LRR_8 203..263 CDD:290566 17/59 (29%)
leucine-rich repeat 205..228 CDD:275380 5/22 (23%)
leucine-rich repeat 229..252 CDD:275380 5/22 (23%)
LRR_8 252..308 CDD:290566 20/84 (24%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 8/51 (16%)
leucine-rich repeat 301..322 CDD:275380 8/20 (40%)
LRR_8 325..384 CDD:290566 15/59 (25%)
leucine-rich repeat 326..350 CDD:275380 10/23 (43%)
leucine-rich repeat 351..373 CDD:275380 4/22 (18%)
lbkNP_611091.2 LRR_RI <275..446 CDD:238064 42/172 (24%)
leucine-rich repeat 293..316 CDD:275380 2/22 (9%)
LRR_8 316..373 CDD:290566 19/57 (33%)
leucine-rich repeat 317..338 CDD:275380 6/21 (29%)
leucine-rich repeat 339..362 CDD:275380 7/22 (32%)
leucine-rich repeat 363..386 CDD:275380 10/22 (45%)
LRR_8 386..445 CDD:290566 17/58 (29%)
leucine-rich repeat 387..410 CDD:275380 6/22 (27%)
leucine-rich repeat 411..434 CDD:275380 8/22 (36%)
leucine-rich repeat 435..457 CDD:275380 6/22 (27%)
LRR_8 457..516 CDD:290566 15/59 (25%)
leucine-rich repeat 458..481 CDD:275380 7/23 (30%)
leucine-rich repeat 482..505 CDD:275380 5/22 (23%)
LRR_RI <498..669 CDD:238064 49/196 (25%)
LRR_8 504..564 CDD:290566 19/59 (32%)
leucine-rich repeat 506..529 CDD:275380 5/22 (23%)
leucine-rich repeat 530..553 CDD:275380 8/22 (36%)
leucine-rich repeat 554..577 CDD:275380 5/22 (23%)
LRR_8 576..641 CDD:290566 20/66 (30%)
leucine-rich repeat 578..604 CDD:275380 1/25 (4%)
leucine-rich repeat 607..630 CDD:275380 9/23 (39%)
leucine-rich repeat 631..652 CDD:275380 10/21 (48%)
LRRCT 665..712 CDD:214507 13/72 (18%)
IG 734..823 CDD:214652 14/88 (16%)
Ig 735..823 CDD:143165 14/87 (16%)
I-set 834..924 CDD:254352 23/107 (21%)
Ig 851..924 CDD:299845 17/72 (24%)
IG 936..1027 CDD:214652 12/52 (23%)
Ig 961..1020 CDD:143165 9/27 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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