DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Rxfp2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001012493.1	Gene:	Rxfp2 / 363866	RGDID:	1309449	Length:	737	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	110/462 - (23%)
Similarity:	195/462 - (42%)	Gaps:	84/462 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSS 91
            |:..|..|.|.:|.|  :|....|..:|          .:.||              :|.|.|..
  Rat    91 LSRYPQHCYCRENEL--ECVNADLKAVP----------KVSSN--------------VTLLSLKK 129

  Fly    92 NHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKI 156
            |.:..:|.:.|:...:|:::.|.||.|..||.:.|:||..:.:|.|..|.|:.|..|.|..|.::
  Rat   130 NKIHRLPVKVFSKYAELRKIFLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQL 194

  Fly   157 EELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQAD 221
            ..|.|.:|.|..:..::|.||:.|..|.:..|.|..:|:.:..| ||.|..:.|..|.::.|...
  Rat   195 AWLILDDNPITRISQRSFTGLNSLFFLSMVSNRLEALPERLCAQ-MPQLNWVDLANNGIKFITNS 258

  Fly   222 AFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQND 286
            .|.....||.|.|....:..:...:|..|:.|..||||.|.:.::|:...|.|..|::|:|..|.
  Rat   259 TFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNVIAKLPAHLFSDLHLLQKLNLSSNP 323

  Fly   287 FEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKML-----LEVQEGALS 346
            ...:.:..|..||||:.|::. .:.:..:.||.|....||.::.|.:.:..     :.:...:..
  Rat   324 LLYVHKNQFGSLKQLQSLDLE-RIEIPNINTGMFRPMKNLSHIYLKTFRYCSYVPHVRICMPSTD 387

  Fly   347 GLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSC--DCRVMWLHNLLVAKNASQDDVSE 409
            |:|..:.  |.||::..::..:..:            ::|  :..|:.:.:|:.|:|.:.....:
  Rat   388 GISSSED--LLANSILRVSVWVIAF------------ITCAGNFLVIAVRSLIKAENTTHAMSIK 438

  Fly   410 LLC--------------EFPERLRGESLRHLNPAMMGCTHADPRKQAL-----IGALLVGSAATI 455
            :||              .|..:.||:.                :|.||     :...|:|..||:
  Rat   439 ILCCADCLMGVYLFSVGVFDIKYRGQY----------------QKYALLWMESVPCRLLGFLATL 487

  Fly   456 TALALVL 462
            :....||
  Rat   488 STEVSVL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	19/58 (33%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	10/22 (45%)
		LRR_RI	129..421	CDD:238064	74/312 (24%)
		LRR_8	132..190	CDD:290566	18/57 (32%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..308	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	8/63 (13%)
		leucine-rich repeat	326..350	CDD:275380	3/28 (11%)
		leucine-rich repeat	351..373	CDD:275380	3/21 (14%)
Rxfp2	NP_001012493.1	LDLa	28..63	CDD:238060
		leucine-rich repeat	96..121	CDD:275380	7/36 (19%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		LRR_RI	134..343	CDD:238064	65/209 (31%)
		LRR_8	145..204	CDD:290566	21/58 (36%)
		leucine-rich repeat	146..169	CDD:275380	10/22 (45%)
		leucine-rich repeat	170..193	CDD:275380	8/22 (36%)
		LRR_8	193..252	CDD:290566	18/59 (31%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..241	CDD:275380	7/23 (30%)
		leucine-rich repeat	242..265	CDD:275380	5/22 (23%)
		LRR_8	265..324	CDD:290566	19/58 (33%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		LRR_8	314..367	CDD:290566	15/53 (28%)
		leucine-rich repeat	314..337	CDD:275380	6/22 (27%)
		leucine-rich repeat	338..357	CDD:275380	4/19 (21%)
		7tm_1	415..674	CDD:278431	18/96 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000