DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and Tril

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001029182.1 Gene:Tril / 362364 RGDID:1310827 Length:811 Species:Rattus norvegicus


Alignment Length:713 Identity:163/713 - (22%)
Similarity:258/713 - (36%) Gaps:204/713 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEG------------QLDVLPIALNP 59
            :..|..|.::......|....:.||..|.|.....::....|            ..|||..:|..
  Rat     4 VGAVRFWLVVCGCLAFPPRAESVCPERCDCQHPQHLLCTNRGLRAVPKTSSLPSPQDVLTYSLGG 68

  Fly    60 S---------------IQRLVIKSNKIKTI-DSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKL 108
            :               ::||.::.|:|::: ..:.:..:.|..|.|.:|.|..:...|.|..:||
  Rat    69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKL 133

  Fly   109 QEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKA 173
            :.::.|.|:||::|..:|.||.::..|.|.||.:..|....|.||..:..|:|..|||.:|...|
  Rat   134 RILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLEANRIRFLGKNA 198

  Fly   174 FDGLSQLRILYLDDNAL-TTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGA 237
            |..|.:||.|.|..|.| .::.....|..:.||:.|.|..|:||.:....||.|..|..|.|.|.
  Rat   199 FTQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLPRLGLLSLSGN 263

  Fly   238 SLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLK 302
            .|.:::.::|.||:.||.|.|..|||:::|...|..|..||.|.|..|:...:....|       
  Rat   264 QLTHLAPEAFWGLEALRELRLEGNRLNQLPLTLLEPLHSLEALDLSGNELSALHPATF------- 321

  Fly   303 RLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEG 367
                                 |:                :|.|..||      |:.|||::|:..
  Rat   322 ---------------------GH----------------QGRLRELS------LRDNALSALSGD 343

  Fly   368 LFPWKD-LQTLDLSENPLSCDCRV----MWLHNLLVAKNASQDDVSELL--CEFPERLRGESLRH 425
            :|.... |..|||..|..:||||:    .|:.|.     .||..:..:.  |..|..|||:.|.:
  Rat   344 IFAASPALYRLDLDGNGWTCDCRLRGLKRWMGNW-----HSQGRLLTVFVQCRHPPALRGKYLDY 403

  Fly   426 LNPAMM---GCTHADPRKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKE 487
            |:..::   .|....|...|       ||                                    
  Rat   404 LDDQLLQNGSCVDPSPSPTA-------GS------------------------------------ 425

  Fly   488 REYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMC------PMPVNDLGAID 546
            |::                |.|           |||.. |.|...|:.      |.|       .
  Rat   426 RQW----------------PIS-----------TAPGE-GMTPPAGLAQELPLQPQP-------Q 455

  Fly   547 PQQKFQQLVVPTATMISEKKLNNNKALV-----SQGAIDDSASFVLHMKSATMGRDVHQQNPQLN 606
            |||: .:|:...|...:.|:|..|::.:     ..|....|.|......||....|:|:: |:..
  Rat   456 PQQR-GRLLPGVAWAGAAKELVGNRSALRLNRRGPGLQHQSPSAAAASGSAPQSLDLHEK-PERG 518

  Fly   607 HYTKPQFLSATATVGDSCYSYADVPMVHGAPLGGP--NQPQLRLTQEHFKQRELYDQEMGSEI 667
            ..|:                 |::|.....|...|  ..|..|.:.:...::.|..::.|..:
  Rat   519 RPTR-----------------ANLPQTEPTPTSEPASGTPSARDSWQRAAKQRLASEQQGRAV 564

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 4/18 (22%)
LRR_8 83..142 CDD:290566 21/58 (36%)
leucine-rich repeat 84..107 CDD:275380 7/22 (32%)
leucine-rich repeat 108..131 CDD:275380 9/22 (41%)
LRR_RI 129..421 CDD:238064 87/299 (29%)
LRR_8 132..190 CDD:290566 22/57 (39%)
leucine-rich repeat 132..155 CDD:275380 8/22 (36%)
leucine-rich repeat 156..179 CDD:275380 9/22 (41%)
leucine-rich repeat 180..204 CDD:275380 7/24 (29%)
LRR_8 203..263 CDD:290566 23/59 (39%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 8/22 (36%)
LRR_8 252..308 CDD:290566 16/55 (29%)
leucine-rich repeat 253..276 CDD:275380 10/22 (45%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
leucine-rich repeat 301..322 CDD:275380 0/20 (0%)
LRR_8 325..384 CDD:290566 15/59 (25%)
leucine-rich repeat 326..350 CDD:275380 3/23 (13%)
leucine-rich repeat 351..373 CDD:275380 6/21 (29%)
TrilNP_001029182.1 LRR_RI 22..313 CDD:238064 87/290 (30%)
leucine-rich repeat 37..57 CDD:275378 1/19 (5%)
LRR 1 61..81 3/19 (16%)
LRR_8 84..143 CDD:290566 15/58 (26%)
LRR 2 84..105 4/20 (20%)
leucine-rich repeat 85..108 CDD:275380 4/22 (18%)
LRR 3 108..129 6/20 (30%)
leucine-rich repeat 109..132 CDD:275380 7/22 (32%)
LRR 4 132..153 8/20 (40%)
leucine-rich repeat 133..156 CDD:275380 9/22 (41%)
LRR_8 156..215 CDD:290566 22/58 (38%)
LRR 5 156..177 6/20 (30%)
leucine-rich repeat 157..180 CDD:275380 8/22 (36%)
LRR 6 180..201 8/20 (40%)
leucine-rich repeat 181..204 CDD:275380 9/22 (41%)
LRR 7 204..223 6/18 (33%)
leucine-rich repeat 205..230 CDD:275380 7/24 (29%)
LRR_8 229..289 CDD:290566 23/59 (39%)
LRR 8 230..251 8/20 (40%)
leucine-rich repeat 231..254 CDD:275380 9/22 (41%)
LRR 9 254..275 6/20 (30%)
leucine-rich repeat 255..278 CDD:275380 8/22 (36%)
LRR 10 278..298 8/19 (42%)
leucine-rich repeat 279..302 CDD:275380 10/22 (45%)
LRR_8 302..359 CDD:290566 21/106 (20%)
LRR 11 302..323 6/48 (13%)
leucine-rich repeat 303..323 CDD:275380 6/47 (13%)
LRR 12 326..347 9/26 (35%)
leucine-rich repeat 327..340 CDD:275378 7/18 (39%)
leucine-rich repeat 351..363 CDD:275378 5/11 (45%)
TPKR_C2 359..406 CDD:301599 16/51 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..460 19/124 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 486..562 16/93 (17%)
FN3 589..661 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
43.970

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