DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and LRRTM3

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_821079.3	Gene:	LRRTM3 / 347731	HGNCID:	19410	Length:	581	Species:	Homo sapiens

Alignment Length:	597	Identity:	133/597 - (22%)
Similarity:	214/597 - (35%)	Gaps:	184/597 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSSNHL 94
            ||.||:|:..  :|.|                     :|.|::.|.|||.  |....|.|..|.|
Human    34 CPKGCRCEGK--MVYC---------------------ESQKLQEIPSSIS--AGCLGLSLRYNSL 73

  Fly    95 MTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEEL 159
            ..:....|....:|..::|:||.|..|....|.|:..:..|.|..|:||.....||.|:..:..|
Human    74 QKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNL 138

  Fly   160 NLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQ 224
            :|..|::..|..:.|.||.:|..|:|..|:|.|:|..:                         ||
Human   139 DLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRI-------------------------FQ 178

  Fly   225 DLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEV 289
            |.:.|..|:|....:|:::.:.|.|:..|:.|.|..|:..::......:||.|:.|.|..|...|
Human   179 DCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISV 243

  Fly   290 ISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNG------NLEYLNLSSNKMLLEVQEGALSGL 348
            |.:........|:||:::|.      ...|||...      ||:.|||.|||:....||
Human   244 IGQTMSWTWSSLQRLDLSGN------EIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQE------ 296

  Fly   349 SQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCE 413
                  :|.:            |..|..:.|:.|...|...:..|.|.|.:....:::.  ::|.
Human   297 ------ILDS------------WISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENT--IICA 341

  Fly   414 FPERLRGESL------------------------------------RHLN----PAMMGCTHADP 438
            .|:.|:|.::                                    :|.:    |..:|.|...|
Human   342 SPKELQGVNVIDAVKNYSICGKSTTERFDLARALPKPTFKPKLPRPKHESKPPLPPTVGATEPGP 406

  Fly   439 RKQA-----LIGALLVGSAA---TITALALVLY--------------------RCRHKIRETIKG 475
            ...|     ....::.||.|   ::..:.||:|                    |.|.|.|:::|
Human   407 ETDADAEHISFHKIIAGSVALFLSVLVILLVIYVSWKRYPASMKQLQQRSLMRRHRKKKRQSLK- 470

  Fly   476 GLWGNSALGRKE--REYQKTFCDEDYM--------------SRHQHHPCSLGIHSTF-----PN- 518
                ......:|  .:|:.|..:...|              ||....|.|:.: |||     |.
Human   471 ----QMTPSTQEFYVDYKPTNTETSEMLLNGTGPCTYNKSGSRECEIPLSMNV-STFLAYDQPTI 530

  Fly   519 TYTAPHHPGATH 530
            :|...||...:|
Human   531 SYCGVHHELLSH 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	6/17 (35%)
		LRR_8	83..142	CDD:290566	16/58 (28%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	72/297 (24%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	13/59 (22%)
		leucine-rich repeat	205..228	CDD:275380	3/22 (14%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..308	CDD:290566	15/55 (27%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		LRR_8	325..384	CDD:290566	15/58 (26%)
		leucine-rich repeat	326..350	CDD:275380	9/23 (39%)
		leucine-rich repeat	351..373	CDD:275380	2/21 (10%)
LRRTM3	NP_821079.3	LRRNT	33..61	CDD:214470	13/51 (25%)
		LRR 1	63..83		5/19 (26%)
		leucine-rich repeat	66..86	CDD:275380	5/19 (26%)
		LRR_8	86..145	CDD:404697	19/58 (33%)
		LRR 2	86..107		7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	8/22 (36%)
		LRR 3	110..131		7/20 (35%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		LRR 4	134..155		5/20 (25%)
		leucine-rich repeat	135..158	CDD:275380	7/22 (32%)
		PPP1R42	156..342	CDD:411060	56/242 (23%)
		LRR 5	158..179		8/45 (18%)
		leucine-rich repeat	159..182	CDD:275380	10/47 (21%)
		LRR 6	182..203		5/20 (25%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		LRR 7	206..226		4/19 (21%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		LRR 8	230..251		6/20 (30%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR 9	254..275		7/26 (27%)
		leucine-rich repeat	255..279	CDD:275380	7/29 (24%)
		LRR 10	279..300		11/32 (34%)
		leucine-rich repeat	280..300	CDD:275380	10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..408		5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010