DRSC/TRiP Functional Genomics Resources

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Protein Alignment trn and LRRTM1

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_849161.2 Gene:LRRTM1 / 347730 HGNCID:19408 Length:522 Species:Homo sapiens


Alignment Length:597 Identity:136/597 - (22%)
Similarity:216/597 - (36%) Gaps:180/597 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IWCIL-ASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID 75
            :.|:| |...:.|||. :.||..|:|          ||:|                         
Human    21 VLCLLGACFQMLPAAP-SGCPQLCRC----------EGRL------------------------- 49

  Fly    76 SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGN 140
                                       .|.:.|......||            ||.:..|:||.|
Human    50 ---------------------------LYCEALNLTEAPHN------------LSGLLGLSLRYN 75

  Fly   141 QISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSL 205
            .:|||..|.||.|:::..|.|..|.|..:...||..|.:::.|.|..|.:|.:|: ..|:.||:|
Human    76 SLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPN-TTFRPMPNL 139

  Fly   206 AELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVG 270
            ..:.|..|.||::..|.|..|:.||.|.::..:::.:....|...:.|:.||:..|:|..:....
Human   140 RSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNS 204

  Fly   271 LSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRV--MTGAFSDNGNLEYLNLSS 333
            .:.|.:|.:|.|..||...::...|..|..|..|    .||..:|  :..:.....|||.::||.
Human   205 FAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSL----CLRRNKVAIVVSSLDWVWNLEKMDLSG 265

  Fly   334 NKMLLEVQE-GALSGLSQLKHVVLKANALTSLAEGLF-PWKDLQTLDLSENPLSCDCRV----MW 392
            |:  :|..| .....:..|:.:.|.:|.||.:...:. .||.|.::.|:.|...|...|    .|
Human   266 NE--IEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASW 328

  Fly   393 LHNLLVAKNASQDDVSELLCEFPERLRGESL------------------RHL-----------NP 428
            |:|.    ....|  ..|.|..||..:||.:                  .||           .|
Human   329 LNNF----QGRYD--GNLQCASPEYAQGEDVLDAVYAFHLCEDGAEPTSGHLLSAVTNRSDLGPP 387

  Fly   429 AMMGCTHAD-----------PRKQALIGA-----------LLVGSAATITA---LALVLY---RC 465
            |....|.||           |...||.|.           ::.|:.|.|.:   :.||||   :|
Human   388 ASSATTLADGGEGQHDGTFEPATVALPGGEHAENAVQIHKVVTGTMALIFSFLIVVLVLYVSWKC 452

  Fly   466 ----RHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHP 526
                ..::|:..        ...|::::.::|......||..:::.           .|...|..
Human   453 FPASLRQLRQCF--------VTQRRKQKQKQTMHQMAAMSAQEYYV-----------DYKPNHIE 498

  Fly   527 GA---THHYGMC 535
            ||   .:.||.|
Human   499 GALVIINEYGSC 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 0/17 (0%)
LRR_8 83..142 CDD:290566 10/58 (17%)
leucine-rich repeat 84..107 CDD:275380 1/22 (5%)
leucine-rich repeat 108..131 CDD:275380 4/22 (18%)
LRR_RI 129..421 CDD:238064 86/299 (29%)
LRR_8 132..190 CDD:290566 21/57 (37%)
leucine-rich repeat 132..155 CDD:275380 11/22 (50%)
leucine-rich repeat 156..179 CDD:275380 7/22 (32%)
leucine-rich repeat 180..204 CDD:275380 7/23 (30%)
LRR_8 203..263 CDD:290566 17/59 (29%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
leucine-rich repeat 229..252 CDD:275380 4/22 (18%)
LRR_8 252..308 CDD:290566 15/55 (27%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
leucine-rich repeat 301..322 CDD:275380 5/22 (23%)
LRR_8 325..384 CDD:290566 18/60 (30%)
leucine-rich repeat 326..350 CDD:275380 7/24 (29%)
leucine-rich repeat 351..373 CDD:275380 6/22 (27%)
LRRTM1NP_849161.2 LRR 1 64..87 11/22 (50%)
LRR_8 73..125 CDD:290566 19/51 (37%)
LRR_RI <85..268 CDD:238064 54/189 (29%)
LRR 2 89..111 6/21 (29%)
leucine-rich repeat 91..114 CDD:275380 7/22 (32%)
LRR 3 112..135 7/23 (30%)
LRR_8 113..173 CDD:290566 19/60 (32%)
leucine-rich repeat 115..138 CDD:275380 7/23 (30%)
LRR 4 137..159 8/21 (38%)
leucine-rich repeat 139..162 CDD:275380 8/22 (36%)
LRR_8 161..221 CDD:290566 14/59 (24%)
LRR 5 161..183 4/21 (19%)
leucine-rich repeat 163..186 CDD:275380 4/22 (18%)
LRR 6 184..207 5/22 (23%)
leucine-rich repeat 187..210 CDD:275380 6/22 (27%)
LRR 7 209..231 6/21 (29%)
leucine-rich repeat 211..234 CDD:275380 7/22 (32%)
LRR 8 233..255 5/25 (20%)
leucine-rich repeat 235..257 CDD:275380 5/25 (20%)
LRR 9 256..278 8/23 (35%)
LRR_8 257..315 CDD:290566 17/59 (29%)
LRR_4 257..297 CDD:289563 13/41 (32%)
leucine-rich repeat 258..281 CDD:275380 7/24 (29%)
LRR 10 279..302 5/22 (23%)
leucine-rich repeat 282..300 CDD:275380 5/17 (29%)
leucine-rich repeat 306..318 CDD:275378 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..401 5/18 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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