DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and CG16974

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	138/539 - (25%)
Similarity:	219/539 - (40%)	Gaps:	129/539 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 IQRLVIKSNKIKTIDSSIQF-YAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNK 124
            ::||.:..|:::.:..:|.. ...:..|::|.|.|.........|.|:|||:||:.:::..:..:
  Fly   205 MERLNLAENRLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNLQYMKQLQELHLDRSELTYLPQR 269

  Fly   125 TFIG-LSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDN 188
             |:| ||.:.:|||..|.::||.:..|...||:|.|.|..||:..|....|...:.|::|.|.||
  Fly   270 -FLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDN 333

  Fly   189 ALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQEL 253
            .|.:.||. .|.....|.:|.|..|.|:||...:...|:.|.:|:|...||..|...:|..|..|
  Fly   334 RLLSFPDN-FFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHL 397

  Fly   254 RILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMG--------------------- 297
            ..|::|.|.|..:.|:....|..|.||.|.:|.|:.:..|.|..
  Fly   398 LALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWI 462

  Fly   298 ------------LKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKML-LEVQEGALSGLS 349
                        |.:|:.|.|....:|..:....|::..|:..|.|:.|.:| |..|   :||||
  Fly   463 SRYDESLVDPQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQ---ISGLS 524

  Fly   350 QLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWL------------HNLLVAKNA 402
            :|:.:.::.|:|.||.|.:...:.|..|::..|...|||.:.||            |.:..|:|.
  Fly   525 RLQRLSVRGNSLGSLPENIKELRQLHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNH 589

  Fly   403 SQDDVSE---------------LLCEFPERLRGESLR--------------------H--LNPAM 430
            |....::               |.|::  ..||:.||                    |  |:.|.
  Fly   590 SNGSTNQTPLDSYESIDHQIDALKCQY--GYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLLSTAK 652

  Fly   431 MGCT---------------------HADPRKQALI-----GALLVGSAATITALALVLYRCRHKI 469
            :.|.                     ||||.|:.:|     .|....||..:.||....|
  Fly   653 LECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESY------ 711

  Fly   470 RETIKGGLW--GNSALGRK 486
               |:...|  .||.:||:
  Fly   712 ---IQSLNWTRQNSLVGRR 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/17 (24%)
		LRR_8	83..142	CDD:290566	19/59 (32%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	8/23 (35%)
		LRR_RI	129..421	CDD:238064	96/352 (27%)
		LRR_8	132..190	CDD:290566	21/57 (37%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	9/23 (39%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..308	CDD:290566	19/88 (22%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	9/55 (16%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	20/59 (34%)
		leucine-rich repeat	326..350	CDD:275380	9/24 (38%)
		leucine-rich repeat	351..373	CDD:275380	6/21 (29%)
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	4/21 (19%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_RI	<246..433	CDD:238064	65/188 (35%)
		LRR_8	251..311	CDD:290566	23/60 (38%)
		leucine-rich repeat	253..276	CDD:275380	8/23 (35%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	20/58 (34%)
		leucine-rich repeat	325..348	CDD:275380	9/23 (39%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		LRR_RI	351..>557	CDD:238064	55/208 (26%)
		LRR_8	371..431	CDD:290566	20/59 (34%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	7/22 (32%)
		leucine-rich repeat	421..444	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	18/61 (30%)
		leucine-rich repeat	478..502	CDD:275380	5/23 (22%)
		leucine-rich repeat	503..526	CDD:275380	10/25 (40%)
		Ig	<714..761	CDD:299845	5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840