DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Toll-4

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	87/430 - (20%)
Similarity:	152/430 - (35%)	Gaps:	129/430 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SIGVEPAAGLANCPPGCQC----DDNTLVVQCGEGQLDVLPIALNP--SIQRLVIKSNKIKTI-D 75
            ::|:...|    ||..|.|    |.:.|.:.|.:..|..:|....|  ....||.:||.:..: |
  Fly   364 TLGINEVA----CPLKCNCSYNRDKSQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPD 424

  Fly    76 SSIQFYAELTFLDLSSNHL--MTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLR 138
            :|::.|..|..||:|.|.|  :::.|    ..:.|..:.:.||||..:|.:....|.:|.|.|..
  Fly   425 NSLEGYHNLKSLDVSYNQLTSLSVSQ----LPESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQY 485

  Fly   139 GNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMP 203
            ||:.|                                       :|.|:.
  Fly   486 GNKWS---------------------------------------IYCDEY--------------- 496

  Fly   204 SLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPS 268
            .|.|.|.....|..|:...||.:.....|..||:.:.|..      :|.:..|.|..|..:.|.:
  Fly   497 HLQEFFWYKAKLLRIKTSKFQTIMEYIELSSKGSFVENFF------VQNIDQLYLEANEDEIIDA 555

  Fly   269 VGLS----KLVRLEQLS----LGQNDFEVI-------------------SEGAFM---------- 296
            .|.|    .|..:|.|:    |...:|:.|                   ..|.|:
  Fly   556 FGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSLDI 620

  Fly   297 --------GLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKH 353
                    ..|....|:.|...:|....:...:.:.::..|::|.| :|.|:....|.  ..:.:
  Fly   621 YPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQN-LLRELPLHLLP--ENITY 682

  Fly   354 VVLKANALTSLAEGLFPW----KDLQTLDLSENPLSCDCR 389
            :.::.|.|..|.:|:..:    :::..::||.||..|:|:
  Fly   683 LDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCK 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	6/18 (33%)
		LRR_8	83..142	CDD:290566	19/60 (32%)
		leucine-rich repeat	84..107	CDD:275380	7/24 (29%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	55/310 (18%)
		LRR_8	132..190	CDD:290566	8/57 (14%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..179	CDD:275380	0/22 (0%)
		leucine-rich repeat	180..204	CDD:275380	2/23 (9%)
		LRR_8	203..263	CDD:290566	15/59 (25%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		LRR_8	252..308	CDD:290566	16/100 (16%)
		leucine-rich repeat	253..276	CDD:275380	7/26 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/63 (11%)
		leucine-rich repeat	301..322	CDD:275380	3/20 (15%)
		LRR_8	325..384	CDD:290566	13/62 (21%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	4/25 (16%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	7/25 (28%)
		leucine-rich repeat	388..408	CDD:275380	4/19 (21%)
		LRR_8	412..465	CDD:290566	17/56 (30%)
		leucine-rich repeat	412..432	CDD:275378	7/19 (37%)
		LRR_4	432..470	CDD:289563	12/41 (29%)
		leucine-rich repeat	433..454	CDD:275378	7/24 (29%)
		leucine-rich repeat	455..478	CDD:275378	7/22 (32%)
		leucine-rich repeat	479..490	CDD:275378	5/10 (50%)
		leucine-rich repeat	632..657	CDD:275378	3/24 (13%)
		leucine-rich repeat	658..679	CDD:275378	6/23 (26%)
		leucine-rich repeat	680..706	CDD:275378	4/25 (16%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380
		leucine-rich repeat	793..815	CDD:275378
		leucine-rich repeat	816..835	CDD:275378
		leucine-rich repeat	836..859	CDD:275378
		TIR	974..1110	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840