Protein Alignment trn and LINGO4

DIOPT Version :10

• Sequence 1: NP_001261796.1
• Gene: trn / 39491
• FlyBaseID: FBgn0010452
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001004432.1
• Gene: LINGO4 / 339398
• HGNCID: 31814
• Length: 593
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 134/463 - (28%)
• Similarity: 196/463 - (42%)
• Gaps: 94/463 - (20%)

  Fly    13 WCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSS 77
            |..|..:.:.|.....:||..|.|......|.||..||:.:|..|....:.|.:..|::..:...
Human    14 WPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQG 78

  Fly    78 -IQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQ 141
             :...:.|..||||.|.|.|:....|...:.|..:.|..|::..:....|.||||:|:|:||.||
Human    79 MLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQ 143

  Fly   142 ISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLA 206
            |.....|.|..|..:::|.:|:|.:.::.|.||.||::|..|.|:...|:|||. :....:|:|.
Human   144 IVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPG-LALARLPALV 207

  Fly   207 ELFL--------------GMNTLQSIQADAFQDLKGL---------------TRLELKGASLRNI 242
            .|.|              |:..|:.::...:..|:.|               ||..|.....:.:
Human   208 ALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQAL 272

  Fly   243 SHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVN 307
            .|.||     ||:||||.|.:..||:..||.||||::|.|.......|:..||.||.
Human   273 YHLSF-----LRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLT-------- 324

  Fly   308 GALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWK 372
                       ||.               ||:|.:                |||.:|.|..||..
Human   325 -----------AFH---------------LLDVAD----------------NALQTLEETAFPSP 347

  Fly   373 D-LQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRH----LNPAMMG 432
            | |.||.||.|||:||||::||..|   :......:|...|..|..::|:||:.    |.|....
Human   348 DKLVTLRLSGNPLTCDCRLLWLLRL---RRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFT 409

  Fly   433 CTHADPRK 440
            |..|..||
Human   410 CKPALIRK 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/18 (11%)
		LRR	82..406	CDD:443914	106/353 (30%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		leucine-rich repeat	205..228	CDD:275380	6/36 (17%)
		leucine-rich repeat	229..252	CDD:275380	7/37 (19%)
		leucine-rich repeat	253..276	CDD:275380	12/22 (55%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	7/21 (33%)
		LRRCT	382..434	CDD:214507	18/55 (33%)
LINGO4	NP_001004432.1	LRRNT	31..64	CDD:214470	11/32 (34%)
		leucine-rich repeat	62..85	CDD:275380	2/22 (9%)
		LRR	<63..342	CDD:443914	89/334 (27%)
		leucine-rich repeat	86..109	CDD:275380	9/22 (41%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		leucine-rich repeat	134..157	CDD:275380	10/22 (45%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		leucine-rich repeat	182..205	CDD:275380	7/23 (30%)
		leucine-rich repeat	206..229	CDD:275380	4/22 (18%)
		leucine-rich repeat	230..277	CDD:275380	7/46 (15%)
		leucine-rich repeat	278..301	CDD:275380	12/22 (55%)
		leucine-rich repeat	302..325	CDD:275380	8/41 (20%)
		leucine-rich repeat	326..344	CDD:275380	9/48 (19%)
		leucine-rich repeat	350..362	CDD:275378	8/11 (73%)
		IG_like	420..501	CDD:214653
		Ig strand B	431..435	CDD:409353
		Ig strand C	444..448	CDD:409353
		Ig strand E	467..471	CDD:409353
		Ig strand F	481..486	CDD:409353
		Ig strand G	494..497	CDD:409353