DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and Lgr6

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001028581.1 Gene:Lgr6 / 329252 MGIID:2441805 Length:967 Species:Mus musculus


Alignment Length:558 Identity:138/558 - (24%)
Similarity:222/558 - (39%) Gaps:155/558 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 VGIW-----CILASIGVEPAAGLAN--CPPGCQCDDNTLVV--QCGEGQLDVLPIALNPSIQRLV 65
            :.:|     |..|..|.:|..|...  ||..|.|.::.:::  .|.|..|.|:|..|:|      
Mouse     8 LALWLCAVLCASARAGSDPQPGPGRPACPAPCHCQEDGIMLSADCSELGLSVVPADLDP------ 66

  Fly    66 IKSNKIKTIDSSIQFYAELT-FLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGL 129
                              || :||||.|:|..:....|.:.:.|:|:.|:.|.:..|..:.|.||
Mouse    67 ------------------LTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL 113

  Fly   130 SAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVP 194
            .::.:|.|:.||:..:.......|..::.|.|..|.|..:..::|:|||.||.|:|||||||.:|
Mouse   114 HSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIP 178

  Fly   195 DPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLS 259
            ...: ..:|:|..:.|.:|.::.|...|||:|..|..|.|....::::...||.||..|..|||:
Mouse   179 VRAL-NNLPALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLN 242

  Fly   260 DNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMG------------------------LKQ 300
            .|.|...| :.:..|.||::|....|:.:.|.|.||||                        |.:
Mouse   243 YNELQEFP-LAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFVGRSAFQYLSK 306

  Fly   301 LKRLEVNGALRLK-----------RVMT-----------GAFSDNGNLEYLNLSSNKM------- 336
            |..|.:|||..::           .::|           |.......|..|.||.|::       
Mouse   307 LHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELSHNQIEELPSLH 371

  Fly   337 --------------LLEVQEGALSGLSQLKHVVLKANALTSL-AEGLFPWKDLQTLDLSEN---- 382
                          :.|:.....|.|..|:.:.|..||:.:: .|.....:.|..|||::|    
Mouse   372 RCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTT 436

  Fly   383 -PLSCDCRVMWLH---NLLVAKNASQDDVSEL---------------LC---------------- 412
             ||:....:|.|.   ||.:::..|:|...:|               :|                
Mouse   437 LPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCAYGICASFFKTSGQWQAEDFH 501

  Fly   413 ----EFPER----LRGESLRH----LNPAMMGCTHADP 438
                |.|:|    |.|::..|    |:...||...:.|
Mouse   502 PEEEEAPKRPLGLLAGQAENHYDLDLDELQMGTEDSKP 539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 0/17 (0%)
LRR_8 83..142 CDD:290566 20/59 (34%)
leucine-rich repeat 84..107 CDD:275380 9/23 (39%)
leucine-rich repeat 108..131 CDD:275380 8/22 (36%)
LRR_RI 129..421 CDD:238064 99/406 (24%)
LRR_8 132..190 CDD:290566 20/57 (35%)
leucine-rich repeat 132..155 CDD:275380 5/22 (23%)
leucine-rich repeat 156..179 CDD:275380 7/22 (32%)
leucine-rich repeat 180..204 CDD:275380 11/23 (48%)
LRR_8 203..263 CDD:290566 21/59 (36%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
leucine-rich repeat 229..252 CDD:275380 7/22 (32%)
LRR_8 252..308 CDD:290566 21/79 (27%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 10/46 (22%)
leucine-rich repeat 301..322 CDD:275380 7/42 (17%)
LRR_8 325..384 CDD:290566 18/85 (21%)
leucine-rich repeat 326..350 CDD:275380 8/44 (18%)
leucine-rich repeat 351..373 CDD:275380 5/22 (23%)
Lgr6NP_001028581.1 LRRNT 34..68 CDD:214470 11/57 (19%)
LRR_4 70..107 CDD:289563 12/36 (33%)
leucine-rich repeat 70..91 CDD:275380 7/20 (35%)
LRR 1 91..112 6/20 (30%)
LRR_8 92..150 CDD:290566 16/57 (28%)
LRR_4 92..131 CDD:289563 12/38 (32%)
leucine-rich repeat 92..115 CDD:275380 8/22 (36%)
LRR 2 115..136 4/20 (20%)
leucine-rich repeat 116..139 CDD:275380 5/22 (23%)
LRR_8 138..198 CDD:290566 23/60 (38%)
LRR 3 139..160 5/20 (25%)
leucine-rich repeat 140..163 CDD:275380 7/22 (32%)
LRR_RI 143..392 CDD:238064 67/250 (27%)
LRR 4 163..186 11/23 (48%)
leucine-rich repeat 164..187 CDD:275380 11/23 (48%)
LRR_8 186..246 CDD:290566 21/59 (36%)
LRR 5 187..208 6/20 (30%)
leucine-rich repeat 188..211 CDD:275380 8/22 (36%)
LRR 6 211..232 5/20 (25%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
LRR 7 235..256 7/21 (33%)
leucine-rich repeat 236..258 CDD:275380 8/22 (36%)
LRR_8 258..314 CDD:290566 13/55 (24%)
LRR 8 258..279 8/20 (40%)
leucine-rich repeat 259..282 CDD:275380 9/22 (41%)
LRR 9 282..302 0/19 (0%)
leucine-rich repeat 283..304 CDD:275380 0/20 (0%)
LRR 10 303..325 6/21 (29%)
LRR_8 305..364 CDD:290566 12/58 (21%)
leucine-rich repeat 307..348 CDD:275380 7/40 (18%)
LRR 11 329..350 2/20 (10%)
LRR 12 353..374 5/20 (25%)
leucine-rich repeat 354..375 CDD:275380 5/20 (25%)
LRR_8 375..434 CDD:290566 13/58 (22%)
LRR 13 375..396 1/20 (5%)
leucine-rich repeat 376..399 CDD:275380 3/22 (14%)
LRR 14 399..420 5/20 (25%)
leucine-rich repeat 400..421 CDD:275380 5/20 (25%)
LRR 15 423..443 7/19 (37%)
leucine-rich repeat 424..444 CDD:275380 7/19 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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