DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lingo4

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_796224.1	Gene:	Lingo4 / 320747	MGIID:	2444651	Length:	618	Species:	Mus musculus

Alignment Length:	463	Identity:	135/463 - (29%)
Similarity:	200/463 - (43%)	Gaps:	94/463 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID-S 76
            |..|..:.:.|...:::||..|.|...|..|.|...:||.:|..|....:.|.:..|::..:. .
Mouse    39 WSPLLFLLLLPGGSISSCPTVCDCTSQTRAVFCAHRRLDTIPGGLPLDTELLDLSGNRLWGLQRG 103

  Fly    77 SIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQ 141
            .:....:|..||||.|.|.|:....|...:.|..:.|..|::..:....|.||:|:|:|:||.||
Mouse   104 MLSRLGQLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIVGPGIFSGLTALTLLDLRLNQ 168

  Fly   142 ISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLA 206
            |.....|.|:.|..:::|.:|:|.:.::.|.||.||::|..:.|:...|:|||...:.| :|:|.
Mouse   169 IVLFLDGAFSELGSLQQLEVGDNHLVFVAPGAFAGLAKLSTITLERCNLSTVPGLALAQ-LPALV 232

  Fly   207 ELFL--------------GMNTLQSIQADAFQDLKGL---------------TRLELKGASLRNI 242
            .|.|              |:..|:.::...:..|:.|               ||..|.....:.:
Mouse   233 ALRLRELDIERLPAGALRGLGQLKELEIHHWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQAL 297

  Fly   243 SHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVN 307
            .|.||     |||||||.|.:..||:..||.||||::|.|.......|:..||.||.
Mouse   298 HHLSF-----LRILDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLT-------- 349

  Fly   308 GALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWK 372
                       ||.               ||:|.:                |||.:|.|..||..
Mouse   350 -----------AFH---------------LLDVAD----------------NALQTLEETAFPSP 372

  Fly   373 D-LQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRH----LNPAMMG 432
            | |.||.||.|||:||||::||..|   :.......|...|..|:.::|:|||.    |.|....
Mouse   373 DKLVTLRLSGNPLTCDCRLLWLLRL---RRRLDFGTSPPACAGPQHVQGKSLREFSDILPPGHFT 434

  Fly   433 CTHADPRK 440
            |..|..||
Mouse   435 CKPALIRK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/18 (11%)
		LRR_8	83..142	CDD:290566	21/58 (36%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	95/321 (30%)
		LRR_8	132..190	CDD:290566	20/57 (35%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	22/88 (25%)
		leucine-rich repeat	205..228	CDD:275380	6/36 (17%)
		leucine-rich repeat	229..252	CDD:275380	7/37 (19%)
		LRR_8	252..308	CDD:290566	23/55 (42%)
		leucine-rich repeat	253..276	CDD:275380	13/22 (59%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	17/59 (29%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	7/21 (33%)
Lingo4	NP_796224.1	LRRNT	56..89	CDD:214470	11/32 (34%)
		leucine-rich repeat	69..86	CDD:275380	6/16 (38%)
		leucine-rich repeat	87..110	CDD:275380	2/22 (9%)
		LRR_8	90..145	CDD:290566	14/54 (26%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		LRR_RI	112..345	CDD:238064	73/238 (31%)
		LRR_8	134..193	CDD:290566	20/58 (34%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	10/22 (45%)
		LRR_8	182..237	CDD:290566	18/55 (33%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	7/23 (30%)
		leucine-rich repeat	231..254	CDD:275380	4/22 (18%)
		leucine-rich repeat	255..302	CDD:275380	7/46 (15%)
		LRR_8	278..334	CDD:290566	24/60 (40%)
		leucine-rich repeat	303..326	CDD:275380	13/22 (59%)
		LRR_8	326..385	CDD:290566	28/108 (26%)
		leucine-rich repeat	327..350	CDD:275380	8/41 (20%)
		leucine-rich repeat	351..369	CDD:275380	9/48 (19%)
		leucine-rich repeat	375..387	CDD:275378	8/11 (73%)
		IG_like	445..526	CDD:214653
		Ig	456..526	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010