DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lingo1

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	143/579 - (24%)
Similarity:	220/579 - (37%)	Gaps:	115/579 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RNMMIAFVGIW--CILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLV 65
            |:|....:..|  .:|..:|...:.....|||.|:|......|.|...:...:|..: |:..||
  Rat    13 RSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGI-PTETRL- 75

  Fly    66 IKSNKIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLS 130
                                 |||..|.:.|:.|..||....|:|:.||.|.:..:....|..|.
  Rat    76 ---------------------LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLF 119

  Fly   131 AVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPD 195
            .:..|.||.|::..:..|.||.|..:.:|::.||:|..|....|..|..|:.|.:.||.|..:..
  Rat   120 NLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISH 184

  Fly   196 PVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLS- 259
            .. |..:.||.:|.|....|.||..:|...|.||..|.|:..::..|...||..|..|::|::|
  Rat   185 RA-FSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISH 248

  Fly   260 ----DN-------------------RLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQL 301
                |.                   .|..:|.:.:..||.|..|:|..|....| ||:.  |.:|
  Rat   249 WPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTI-EGSM--LHEL 310

  Fly   302 KRLE----VNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALT 362
            .||:    |.|.|.:                           |:..|..||:.|:.:.:..|.||
  Rat   311 LRLQEIQLVGGQLAV---------------------------VEPYAFRGLNYLRVLNVSGNQLT 348

  Fly   363 SLAEGLF-PWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRH- 425
            :|.|..| ...:|:||.|..|||:||||::|:.......|.::...:   |..||.::|:..:.
  Rat   349 TLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPT---CATPEFVQGKEFKDF 410

  Fly   426 ---LNPAMMGC--THADPRKQALIGALLVGSAATITALA----------LVLYRCRHKIRETIKG 475
               |.|....|  .|...||...:   .|....|:..:.          |.|...:|.:.....|
  Rat   411 PDVLLPNYFTCRRAHIRDRKAQQV---FVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNG 472

  Fly   476 GL--WGNSALGRKEREYQKT---FCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGAT 529
            .|  :.:..|..:..:.|..   .|.......:...|..|.:.|..|:.   ||.|..|
  Rat   473 RLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDW---PHQPNKT 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	19/58 (33%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	88/320 (28%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	6/23 (26%)
		LRR_8	203..263	CDD:290566	21/83 (25%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	20/83 (24%)
		leucine-rich repeat	253..276	CDD:275380	7/46 (15%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	6/24 (25%)
		LRR_8	325..384	CDD:290566	16/59 (27%)
		leucine-rich repeat	326..350	CDD:275380	4/23 (17%)
		leucine-rich repeat	351..373	CDD:275380	7/22 (32%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	9/34 (26%)
		LRR	<66..371	CDD:227223	95/358 (27%)
		leucine-rich repeat	73..96	CDD:275380	10/44 (23%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		LRR_8	120..179	CDD:404697	19/58 (33%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		leucine-rich repeat	145..192	CDD:275380	13/47 (28%)
		leucine-rich repeat	193..216	CDD:275380	8/22 (36%)
		leucine-rich repeat	217..264	CDD:275380	11/46 (24%)
		leucine-rich repeat	265..288	CDD:275380	3/22 (14%)
		leucine-rich repeat	289..312	CDD:275380	9/25 (36%)
		leucine-rich repeat	313..336	CDD:275380	8/49 (16%)
		leucine-rich repeat	337..357	CDD:275380	7/19 (37%)
		PCC	341..>421	CDD:188093	25/82 (30%)
		IgI_Lingo-1	423..514	CDD:409561	15/93 (16%)
		Ig strand B	442..446	CDD:409561	0/3 (0%)
		Ig strand C	455..459	CDD:409561	1/3 (33%)
		Ig strand E	480..484	CDD:409561	1/3 (33%)
		Ig strand F	494..499	CDD:409561	1/4 (25%)
		Ig strand G	507..510	CDD:409561	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I11953
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8997
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010