DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Cpn2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001100555.1	Gene:	Cpn2 / 303861	RGDID:	1305170	Length:	565	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	134/553 - (24%)
Similarity:	217/553 - (39%)	Gaps:	123/553 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVGIWCILASI-----GVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIAL----------- 57
            |.|.|...||:     ..:|      ||.||.|.|..:.  |.:.||..:|:.:
  Rat    25 FQGAWLCWASLLLLVRVTQP------CPVGCDCFDRKIF--CSDEQLAAIPLDIPSHVTDIVFVE 81

  Fly    58 -------------NPSIQRLVIKSNKIKTIDS----------------------SIQFYAELTF- 86
                         :|::.::|..:.::..::.                      |...::.|:.
  Rat    82 TSFTTVGTRAFSGSPNLTKVVFLNTRVHHLEPDAFGGLPRLEDLEVTGSPFSNLSANIFSNLSSL 146

  Fly    87 --LDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGT 149
              |.|..|.|..:|:..|.:...|:.:.|..|::..:..:.|..|..:..|||..|.:::|.:|.
  Rat   147 GKLTLDFNRLAALPEDLFHHMDTLESLQLQGNQLQTLPGRLFQSLRYLRTLNLAQNLLTQLPKGM 211

  Fly   150 FTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNT 214
            |..|..::.|.|.:|....|.......|..|:.|:||.||:|.: .|.:|..:.||.:|:|..|.
  Rat   212 FQSLSSLQILKLSDNMFARLPEGVLSNLGSLQELFLDSNAITEL-SPHLFSHLLSLEKLWLQHNA 275

  Fly   215 LQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQ 279
            :..:...||..|:.||.|.||..:||.:....|.....|..|.||.|:|:.:|....:.|.:|..
  Rat   276 ISHLPVSAFSSLRNLTFLNLKDNALRTLPAGLFTHNPGLLHLSLSYNQLETVPEGSFANLRKLAS 340

  Fly   280 LSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGA 344
            |:|..|....:.|..|..|:||.:|.:               |:.||..|:.:           .
  Rat   341 LTLSHNAITHLPENVFRNLEQLVKLSL---------------DSNNLTVLHPT-----------L 379

  Fly   345 LSGLSQLKHVVLKANALTSLAEGLFPWK-DLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDV- 407
            ...||:|:.:.|..|.||.|..|:|... ||..|.|..||..||||:.:|.:.|...|   |.:
  Rat   380 FHNLSKLQLLDLSRNQLTMLPGGIFDTNYDLFNLALLGNPWQCDCRLSYLTSWLRLYN---DRIF 441

  Fly   408 -SELLCEFPERLRGESLRHL---------NPAMMGCTHADP--------RKQALIGALLVGSAAT 454
             :...|..|..|:|:.:.:|         ||..:|....:|        ..:|.....:.|:...
  Rat   442 NTHTFCAGPAYLKGQLVPNLKQEQLVCPGNPGQLGLDDREPAGSWDLAVEGRAAHRQCIYGNPEG 506

  Fly   455 ITALALVLYRCRHKIRETIKGGLWGNSALGRKE 487
            ...||....:||           |.|..|..:|
  Rat   507 TVLLACEEAQCR-----------WLNIQLSSRE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/39 (5%)
		LRR_8	83..142	CDD:290566	16/61 (26%)
		leucine-rich repeat	84..107	CDD:275380	7/25 (28%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_RI	129..421	CDD:238064	88/294 (30%)
		LRR_8	132..190	CDD:290566	18/57 (32%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	5/22 (23%)
		leucine-rich repeat	180..204	CDD:275380	9/23 (39%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..308	CDD:290566	18/55 (33%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	18/59 (31%)
		leucine-rich repeat	326..350	CDD:275380	3/23 (13%)
		leucine-rich repeat	351..373	CDD:275380	8/22 (36%)
Cpn2	NP_001100555.1	LRRNT	44..75	CDD:214470	11/38 (29%)
		leucine-rich repeat	77..97	CDD:275380	0/19 (0%)
		LRR_8	96..156	CDD:290566	7/59 (12%)
		leucine-rich repeat	122..145	CDD:275380	2/22 (9%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR_8	169..226	CDD:290566	15/56 (27%)
		leucine-rich repeat	170..193	CDD:275380	5/22 (23%)
		LRR_RI	172..418	CDD:238064	78/272 (29%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		LRR_8	241..300	CDD:290566	22/59 (37%)
		leucine-rich repeat	242..265	CDD:275380	9/23 (39%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		LRR_8	288..348	CDD:290566	20/59 (34%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..337	CDD:275380	8/22 (36%)
		LRR_8	336..396	CDD:290566	19/85 (22%)
		leucine-rich repeat	338..361	CDD:275380	7/22 (32%)
		leucine-rich repeat	362..383	CDD:275380	6/46 (13%)
		leucine-rich repeat	386..405	CDD:275380	7/18 (39%)
		LRRCT	418..459	CDD:214507	14/43 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020