DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Nyx

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001094437.1	Gene:	Nyx / 302516	RGDID:	1561300	Length:	476	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	113/403 - (28%)
Similarity:	167/403 - (41%)	Gaps:	59/403 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AGLANCPPGCQCD--DNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFL 87
            |.|..||..|.|.  :....|:|....|..:|                       .:|..|...:
  Rat    21 ACLRACPAACTCSNVERGCSVRCDRAGLQRVP-----------------------TEFPCEAASI 62

  Fly    88 DLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTP 152
            ||..|.|..:.:|.|.                        .|.::..|:||.|.:|.:..|.|..
  Rat    63 DLDRNGLRILGERAFG------------------------TLPSLRCLSLRHNNLSFITPGAFKG 103

  Fly   153 LLKIEELNLGEN-RIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQ 216
            |.::.||.|..| .:.||..:.|..|.:||.|.|....|.:||:.::.: :|:|.||....|..:
  Rat   104 LPRLAELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPERLLAE-LPALRELTAFDNLFR 167

  Fly   217 SIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLS 281
            .:.. |.:.|..||....:.:.:..::..|.||::.||.|.|..||:..:.:......|.||.|.
  Rat   168 RVPG-ALRGLANLTHAHFERSRIEAVASSSLLGMRRLRSLSLQANRVRAVHAGAFGDCVALEHLL 231

  Fly   282 LGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALS 346
            |..|....:...||.||::|:.|.:.|. .|..|..|.|||...||.|.|..|.:.. |:|||..
  Rat   232 LNDNLLASLPAAAFRGLRRLRTLNLGGN-ALGSVARGWFSDLAELELLYLDRNSITF-VEEGAFQ 294

  Fly   347 GLSQLKHVVLKANALTSLAEGLF-PWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSEL 410
            .||.|..:.|..|.||.|:...| |...|..|.|..||..|||.:.||.:.:.....    |:::
  Rat   295 NLSGLLALHLNGNRLTVLSWAAFQPGFFLGRLFLFRNPWRCDCHLEWLRDWMEGSGR----VADV 355

  Fly   411 LCEFPERLRGESL 423
            .|..|..:.|:.|
  Rat   356 ACASPGSVAGQDL 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	0/17 (0%)
		LRR_8	83..142	CDD:290566	12/58 (21%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	1/22 (5%)
		LRR_RI	129..421	CDD:238064	93/293 (32%)
		LRR_8	132..190	CDD:290566	20/58 (34%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	8/23 (35%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	17/59 (29%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..308	CDD:290566	18/55 (33%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..322	CDD:275380	7/20 (35%)
		LRR_8	325..384	CDD:290566	23/59 (39%)
		leucine-rich repeat	326..350	CDD:275380	10/23 (43%)
		leucine-rich repeat	351..373	CDD:275380	8/22 (36%)
Nyx	NP_001094437.1	LRRNT	25..56	CDD:214470	8/53 (15%)
		leucine-rich repeat	63..82	CDD:275380	7/42 (17%)
		LRR_RI	<68..312	CDD:238064	80/271 (30%)
		LRR_8	81..142	CDD:290566	20/60 (33%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		leucine-rich repeat	107..131	CDD:275380	8/23 (35%)
		leucine-rich repeat	132..155	CDD:275380	7/23 (30%)
		leucine-rich repeat	156..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		LRR_8	201..261	CDD:290566	19/60 (32%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		leucine-rich repeat	227..250	CDD:275380	9/22 (41%)
		LRR_8	249..309	CDD:290566	23/61 (38%)
		leucine-rich repeat	251..274	CDD:275380	9/23 (39%)
		leucine-rich repeat	275..296	CDD:275380	9/21 (43%)
		leucine-rich repeat	299..318	CDD:275380	6/18 (33%)
		LRRCT	331..>366	CDD:214507	10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010