DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lrrc66

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001008763.1	Gene:	Lrrc66 / 289587	RGDID:	1306094	Length:	865	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	153/780 - (19%)
Similarity:	231/780 - (29%)	Gaps:	324/780 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SNKIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAV 132
            |.|..|:|.:..|:..|                   :|...:|.|.||
  Rat    50 SQKTDTVDRNSYFFRVL-------------------FQPHTKERHTNH----------------- 78

  Fly   133 TVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPV 197
              |:...:::|::.......|..:|.||||::.|              ..|.||
  Rat    79 --LDRTNHRLSKVTLSCLAHLRALEMLNLGDDVI--------------HSLCLD----------- 116

  Fly   198 IFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQ-ELRILDLSDN 261
                                              |.|..:|.:......|.|.. .|::|.|..|
  Rat   117 ----------------------------------LSLPSSSRQKRHRSRFRGRHPRLKVLLLQRN 147

  Fly   262 RLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNL 326
            :|...|. ||.||..|..|.|..|....|....|.|..|||.:
  Rat   148 QLGPTPK-GLWKLKPLCSLDLSFNRRVGIGLSGFHGCLQLKSI---------------------- 189

  Fly   327 EYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGL---FPWKDLQTLDLSENPLSCDC 388
             ||   .|..:|.:...|..||.:|:.|.|:::|||.|...:   ..|.:|: |.|::|...|:.
  Rat   190 -YL---KNNKILTIHPEAFKGLKKLQVVDLRSSALTMLVPIVTIALEWPNLE-LGLADNQWQCNE 249

  Fly   389 RVMWLHNLLVAKNASQDDVSELLCEFPER-----LRGESLR-----HLNPAMMGCTHADPRK--- 440
            ......|:   .:.|..::.:.:|..|..     :....:|     ||           ||.
  Rat   250 SDANFQNI---ASVSWGEIWKAVCNTPVENEKPYVEASQIRISRDIHL-----------PRSPSS 300

  Fly   441 --QALIGALL----VGSAATITAL---ALVLYRCRHKIRETIKGGLW-----------GNSALGR 485
              |:||.:..    .|....::||   |.|.|       ..:| |:|           |.....|
  Rat   301 DLQSLIQSKAEKPRAGMDVHLSALEKKAQVGY-------GDLK-GIWLQSPMELRDSQGGPVTDR 357

  Fly   486 KERE---------------YQKTFC----DEDYMSRHQHHPC------------SLGIHSTFPNT 519
            |:.:               :...||    ...|:.|.:...|            :.|.|.   :.
  Rat   358 KDDKPPDLALAVCLSVFITFVVAFCLGAFARPYIDRLRQQRCLNKRPGSENAYSNEGFHD---DV 419

  Fly   520 YTAPH--HPG-----ATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMISEKKLNNN----KAL 573
            ..|.|  |.|     .|||       :|.....||....:  .:|...::||:.|.:|    .:.
  Rat   420 EAAQHVQHQGTDLCQTTHH-------LNLFENQDPSWGTE--AIPHGAVLSERMLGSNGMDPSSQ 475

  Fly   574 VSQGAIDDSASF------------VLH-----MKSATMGRDVHQQNPQLNHYTKPQFLSATATVG 621
            .|.|..:||...            |:|     :.||...:.:   :|..:||..|: .|...||.
  Rat   476 QSPGQFEDSGEARSGDGNMFPNGRVVHPAVHGLPSADAQKPI---SPGQHHYDVPE-ESLYDTVA 536

  Fly   622 DSCYSYADVPMVHGAPLG----------------GPNQPQ-----LRLTQEHFKQRELYDQ---- 661
            .. ||..|..|...:..|                .|:||:     ...|..|...||..:.
  Rat   537 QE-YSLLDNAMDRSSVAGCLGTFPNSINSGRDELCPSQPRDVVASFSKTLAHMSTREAEESVERG 600

  Fly   662 ------EMGSEI------------------------------LDHNY---IYSNTHYSMPLEQLG 687
                  .|||:|                              |.|.|   :|::|...||....|
  Rat   601 FPEPLGAMGSQIESSEERQVSNSIRELATQQASFQEVDVEERLAHVYSEALYNDTPSHMPRHSSG 665

Fly 688 687
Rat 666 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/11 (36%)
		LRR_8	83..142	CDD:290566	7/58 (12%)
		leucine-rich repeat	84..107	CDD:275380	2/22 (9%)
		leucine-rich repeat	108..131	CDD:275380	4/22 (18%)
		LRR_RI	129..421	CDD:238064	61/300 (20%)
		LRR_8	132..190	CDD:290566	12/57 (21%)
		leucine-rich repeat	132..155	CDD:275380	3/22 (14%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..204	CDD:275380	3/23 (13%)
		LRR_8	203..263	CDD:290566	9/60 (15%)
		leucine-rich repeat	205..228	CDD:275380	0/22 (0%)
		leucine-rich repeat	229..252	CDD:275380	5/23 (22%)
		LRR_8	252..308	CDD:290566	20/55 (36%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		LRR_8	325..384	CDD:290566	19/61 (31%)
		leucine-rich repeat	326..350	CDD:275380	7/23 (30%)
		leucine-rich repeat	351..373	CDD:275380	8/24 (33%)
Lrrc66	NP_001008763.1	leucine-rich repeat	78..99	CDD:275380	4/39 (10%)
		LRR_RI	<135..>243	CDD:238064	38/135 (28%)
		LRR 1	138..160		9/22 (41%)
		leucine-rich repeat	139..161	CDD:275380	10/22 (45%)
		LRR 2	161..182		6/20 (30%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	164..220	CDD:290566	19/81 (23%)
		LRR 3	185..206		8/46 (17%)
		leucine-rich repeat	186..209	CDD:275380	9/48 (19%)
		LRR 4	209..230		7/20 (35%)
		leucine-rich repeat	210..235	CDD:275380	8/24 (33%)
		LRR 5	235..255		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..522		11/61 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..749		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..865
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100