DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Elfn1

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001099383.1	Gene:	Elfn1 / 288512	RGDID:	1308787	Length:	829	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	100/467 - (21%)
Similarity:	151/467 - (32%)	Gaps:	145/467 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 LDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAF 320
            |.|::||:..:....||:...|..|:|.:|:...|.:|||.|...|:.|:: |..||:.:..|..
  Rat    65 LRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQL-GYNRLRNLTEGML 128

  Fly   321 SDNGNLEYLNLSSNKMLLE-VQEGALSGLSQLKHVVLKANALTSLAEGLFP-WKDLQTLDLSENP 383
            .....||||.|.:|  |:| |...|......:.::.|..|.:..|..|.|. ...|...::..||
  Rat   129 RGLSKLEYLYLQAN--LIEVVMASAFWECPNIVNIDLSMNRIQQLGSGTFAGLTKLSVCEIYSNP 191

  Fly   384 LSCDCRVM-WLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGAL 447
            ..|.|.:: :|..|....||:|.. ..:.||.|                         ....|..
  Rat   192 FYCSCELLGFLRWLAAFTNATQTH-DRVQCESP-------------------------PVYAGYF 230

  Fly   448 LVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGI 512
            |:|..             ||..:.:|...|              ::.|.|...:.....|
  Rat   231 LLGQG-------------RHGHQRSILSKL--------------QSVCTEGSYTAEVLGP----- 263

  Fly   513 HSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQ----QKFQQLVVPTATMISE--------- 564
                |........||  |.....|...:|:...|.:    .....|||.| |::.:
  Rat   264 ----PRPVPGRSQPG--HSPPPPPPEPSDMPCADDECFSGDGTTPLVVLT-TLVPQTEARPSMKV 321

  Fly   565 KKLNNNKALVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTKPQF-LSATATVGDSCYSYA 628
            |:|..|.|.:.                      |...:|....||..|: .|.:.||.
  Rat   322 KQLTQNSATIM----------------------VQLPSPFNRMYTLEQYNNSKSFTVS------- 357

  Fly   629 DVPMVHGAPLGGPNQPQLRLTQEHFKQRELYDQEMGSEILDHNYIY------SNTHYSMPLEQLG 687
                            :|...||..:...||...        ||.|      |.||::.....:.
  Rat   358 ----------------KLTQPQEEIRLTNLYTLT--------NYTYCVVSTSSGTHHNHTCLTIC 398

  Fly   688 RSKTPTPP-PMP 698
            ..|.|:|| |:|
  Rat   399 LPKPPSPPGPVP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380
		LRR_8	83..142	CDD:290566
		leucine-rich repeat	84..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		LRR_RI	129..421	CDD:238064	49/167 (29%)
		LRR_8	132..190	CDD:290566
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..179	CDD:275380
		leucine-rich repeat	180..204	CDD:275380
		LRR_8	203..263	CDD:290566	3/6 (50%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..308	CDD:290566	17/51 (33%)
		leucine-rich repeat	253..276	CDD:275380	6/19 (32%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		LRR_8	325..384	CDD:290566	17/60 (28%)
		leucine-rich repeat	326..350	CDD:275380	10/24 (42%)
		leucine-rich repeat	351..373	CDD:275380	5/22 (23%)
Elfn1	NP_001099383.1	LRR	<44..>186	CDD:227223	37/123 (30%)
		leucine-rich repeat	65..85	CDD:275378	6/19 (32%)
		LRR_8	85..144	CDD:404697	21/61 (34%)
		leucine-rich repeat	86..109	CDD:275378	9/22 (41%)
		leucine-rich repeat	110..133	CDD:275378	6/23 (26%)
		leucine-rich repeat	134..157	CDD:275378	10/24 (42%)
		leucine-rich repeat	158..171	CDD:275378	2/12 (17%)
		LRRCT	190..>228	CDD:214507	12/63 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100