DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and HMCN2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001278744.1	Gene:	HMCN2 / 256158	HGNCID:	21293	Length:	5079	Species:	Homo sapiens

Alignment Length:	651	Identity:	134/651 - (20%)
Similarity:	216/651 - (33%)	Gaps:	257/651 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 GLSQLRILYLDDNALT--------TVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRL 232
            |...||:|.....|:.        ||..|....|  :||.:|   :...|:..:..|.:.|.:|:
Human     4 GAPLLRLLTAVSAAVAVAVAGAPGTVMPPTTGDA--TLAFVF---DVTGSMWDELMQVIDGASRI 63

  Fly   233 ELKGASLRNIS---------HDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRL--------EQL 280
            ..:..|.|:.:         ||.          |:....|...|:|...:|..|        .::
Human    64 LERSLSRRSQAIANYALVPFHDP----------DIGPVTLTADPTVFQRELRELYVQGGGDCPEM 118

  Fly   281 SLG--QNDFEVISEGAFMGL------------KQLKRLEVNGALRLKR-----VMTGAFSDNGNL 326
            |:|  :...||.:.|:|:.:            ::|.||     |:||:     |:||...|..:.
Human   119 SVGAIKAAVEVANPGSFIYVFSDARAKDYHKKEELLRL-----LQLKQSQVVFVLTGDCGDRTHP 178

  Fly   327 EYLNLSSNKMLLEVQEGALSGLSQLKHV-------VLK-------ANALTSLA-----EGLFPW- 371
            .|         |..:|.|.:...|:.|:       |||       |:.:..|:     ||...|
Human   179 GY---------LAYEEIAATSSGQVFHLDKQQVTEVLKWVESAIQASKVHLLSTDHEEEGEHTWR 234

  Fly   372 -------KDLQTLDLS--------ENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGE 421
                   |:: |:.||        ::||.   |::           .:|:...:|...|:..:..
Human   235 LPFDPSLKEV-TISLSGPGPEIEVQDPLG---RIL-----------QEDEGLNVLLNIPDSAKVV 284

  Fly   422 SLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRK 486
            :.:..:|.:.              ::.|.|:.            ||.:|.|           |..
Human   285 AFKPEHPGLW--------------SIKVYSSG------------RHSVRIT-----------GVS 312

  Fly   487 EREYQKTFCDEDYMSRH-------QHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGA 544
            ..:::..|..:..:..:       |..|.||.|:||   ...||                   |.
Human   313 NIDFRAGFSTQPLLDLNHTLEWPLQGVPISLVINST---GLKAP-------------------GR 355

  Fly   545 IDPQQKFQQLVVPTATMISEKKLNNNKALVSQGA---IDDSASFVLHMKSATMGRDVHQQNPQLN 606
            :|..:..|....|..| :..|.|:|.......|.   ......|.|.:|    |:| |:.||.|.
Human   356 LDSVELAQSSGKPLLT-LPTKPLSNGSTHQLWGGPPFHTPKERFYLKVK----GKD-HEGNPLLR 414

  Fly   607 HYTKPQFLSATATVGDSCYSYADV----PMVHGAPL--GGPNQPQL------------------- 646
                           .|..||:.|    |:|..||.  |..:||.|
Human   415 ---------------VSGVSYSGVAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGE 464

  Fly   647 -RLTQE-HFKQRELYDQEMGS---EILDHNYIYSNTHYSMPLEQ--LGRSK-----TPTPPPMPP 699
             ||.:| ||       ||.|:   |||..:.....|:....:.:  .||:|     |..||.:.|
Human   465 ARLGEERHF-------QESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVP 522

  Fly   700 A 700
            |
Human   523 A 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380
		LRR_8	83..142	CDD:290566
		leucine-rich repeat	84..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		LRR_RI	129..421	CDD:238064	66/323 (20%)
		LRR_8	132..190	CDD:290566	4/13 (31%)
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..179	CDD:275380	1/2 (50%)
		leucine-rich repeat	180..204	CDD:275380	8/31 (26%)
		LRR_8	203..263	CDD:290566	12/68 (18%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	5/31 (16%)
		LRR_8	252..308	CDD:290566	15/77 (19%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	7/44 (16%)
		leucine-rich repeat	301..322	CDD:275380	9/25 (36%)
		LRR_8	325..384	CDD:290566	18/93 (19%)
		leucine-rich repeat	326..350	CDD:275380	4/23 (17%)
		leucine-rich repeat	351..373	CDD:275380	9/48 (19%)
HMCN2	NP_001278744.1	VWA_2	39..209	CDD:290253	42/196 (21%)
		IG_like	434..513	CDD:214653	20/85 (24%)
		Ig	442..503	CDD:299845	15/67 (22%)
		IG	524..604	CDD:214652	134/651 (21%)
		Ig	534..601	CDD:143165
		I-set	608..692	CDD:254352
		IGc2	621..684	CDD:197706
		IG_like	712..782	CDD:214653
		Ig	715..779	CDD:143165
		Ig	785..869	CDD:299845
		IG	792..879	CDD:214652
		I-set	885..972	CDD:254352
		IGc2	898..962	CDD:197706
		IG	988..1063	CDD:214652
		Ig	995..1062	CDD:299845
		I-set	1079..1161	CDD:254352
		IGc2	1088..1151	CDD:197706
		I-set	1165..1246	CDD:254352
		IGc2	1179..1236	CDD:197706
		IG	1258..1340	CDD:214652
		Ig	1266..1340	CDD:299845
		IG	1354..1433	CDD:214652
		IGc2	1360..1423	CDD:197706
		IG	1446..1527	CDD:214652
		IGc2	1453..1517	CDD:197706
		IG	1540..1620	CDD:214652
		Ig	1540..1620	CDD:299845
		I-set	1632..1716	CDD:254352
		IGc2	1641..1704	CDD:197706
		IG	1727..1807	CDD:214652
		IGc2	1734..1797	CDD:197706
		Ig	1820..1893	CDD:299845
		IG_like	1827..1891	CDD:214653
		I-set	1895..1975	CDD:254352
		Ig	1912..1975	CDD:143165
		I-set	1986..2076	CDD:254352
		IGc2	2001..2066	CDD:197706
		Ig	2079..2169	CDD:299845
		I-set	2080..2167	CDD:254352
		I-set	2171..2261	CDD:254352
		IGc2	2185..2251	CDD:197706
		I-set	2273..2355	CDD:254352
		Ig	2285..2352	CDD:143165
		I-set	2367..2449	CDD:254352
		Ig	2379..2449	CDD:299845
		Ig	2452..2542	CDD:299845
		IG_like	2462..2542	CDD:214653
		IG	2558..2638	CDD:214652
		IGc2	2565..2628	CDD:197706
		IG	2656..2736	CDD:214652
		IGc2	2663..2726	CDD:197706
		IG_like	2770..2847	CDD:214653
		IGc2	2773..2837	CDD:197706
		IG	2862..2942	CDD:214652
		Ig	2868..2942	CDD:299845
		IG_like	2954..3034	CDD:214653
		IGc2	2961..3024	CDD:197706
		I-set	3038..3129	CDD:254352
		IGc2	3056..3119	CDD:197706
		I-set	3133..3221	CDD:254352
		IGc2	3148..3208	CDD:197706
		IG	3234..3318	CDD:214652
		IGc2	3240..3306	CDD:197706
		IG	3329..3410	CDD:214652
IGc2	3336..3400	CDD:197706
IG_like	3424..3499	CDD:214653
IGc2	3430..3489	CDD:197706
I-set	3503..3590	CDD:254352
IGc2	3518..3580	CDD:197706
I-set	3602..3683	CDD:254352
IGc2	3610..3673	CDD:197706
IG	3693..3774	CDD:214652
Ig	3693..3774	CDD:299845
Ig	3777..3859	CDD:299845
IG	3784..3867	CDD:214652
IG_like	3887..3958	CDD:214653
IGc2	3887..3948	CDD:197706
IG	3968..4048	CDD:214652
Ig	3979..4040	CDD:299845
I-set	4052..4139	CDD:254352
IGc2	4065..4129	CDD:197706
I-set	4143..4228	CDD:254352
IGc2	4157..4218	CDD:197706
I-set	4246..4317	CDD:254352
IGc2	4247..4309	CDD:197706
Ig	4322..4405	CDD:299845
I-set	4323..4409	CDD:254352
G2F	4411..4593	CDD:284812
FXa_inhibition	4652..4687	CDD:291342
EGF_CA	4689..4732	CDD:214542
EGF_CA	4733..4774	CDD:284955
EGF_CA	4776..4815	CDD:284955
EGF_CA	4883..4922	CDD:214542
EGF_CA	4923..4963	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100