DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Elfn1

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001371115.1	Gene:	Elfn1 / 243312	MGIID:	2442479	Length:	828	Species:	Mus musculus

Alignment Length:	770	Identity:	167/770 - (21%)
Similarity:	248/770 - (32%)	Gaps:	266/770 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 IPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNL 161
            |||:   ....:.::.||.|:|..:...:......:|.|||..|:|..:..|.|:....::.|.|
Mouse    54 IPQQ---INNTIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQL 115

  Fly   162 GENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDL 226
            |.||:..|......|||:|..|||..|.:..|.....::. |::..:.|.||.:|.:.:..|
Mouse   116 GYNRLRNLTEGMLRGLSKLEYLYLQANLIEVVMASAFWEC-PNIVNIDLSMNRIQQLGSGTF--- 176

  Fly   227 KGLTRL--------------ELKG-----ASLRNI--SHDS------------FLGLQELRILDL 258
            .|||:|              ||.|     |:..|.  :||.            ||         |
Mouse   177 AGLTKLSVCEIYSNPFYCSCELLGFLRWLAAFTNATQTHDRVQCESPPVYAGYFL---------L 232

  Fly   259 SDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALR--LKRVMTG--- 318
            ...|.....|: ||||.            .|.:||::..       ||.|..|  ..|...|
Mouse   233 GQGRHGHQRSI-LSKLQ------------SVCTEGSYTA-------EVLGPPRPVPGRSQPGHSP 277

  Fly   319 ----------------AFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEG 367
                            .||.:|....:.|::   |:...|...|    :|...|..|:.|.:.:.
Mouse   278 PPPPPEPSDMPCADDECFSGDGTTPLVILTT---LVPQTEARPS----MKVKQLTQNSATIMVQL 335

  Fly   368 LFPWKDLQTLDLSENPLSCDCRVMW-------LHNLLVAKNASQDDVSE-----------LLC-E 413
            ..|:..:.||:...|..|.....:.       |.||....|.:...||.           .:| .
Mouse   336 PSPFNRMYTLEQYNNSKSFTVSKLTQPQEEIRLTNLYTLTNYTYCVVSTSSGTHHNHTCLTICLP 400

  Fly   414 FPERLRG-----ESLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLYRCRHKIRETI 473
            .|....|     .:..|....::||         |.|.:||        |..|.|..|.:.|:..
Mouse   401 KPPSPPGPVPSPSTATHYIMTILGC---------LFGMVLV--------LGAVYYCLRKRRRQEE 448

  Fly   474 KGGLWGNSALGRKEREYQKTFCDEDY--------MSRHQHHPCSLGIHSTFPNTYT-APHHPGAT 529
            |    ...|:.......:||..:..|        ::.....|. ||     |...| .|:.|.||
Mouse   449 K----HKKAVAAAAGSLKKTIIELKYGPEIEAPGLAPLTQGPL-LG-----PEAVTRIPYLPAAT 503

  Fly   530 ---HHYGM-----CPMPVN----DLGAIDPQQKF----------QQLVVPTATMISE----KKLN 568
               ..|.:     .|....    ::...:||::.          |..|...:|:..|    .::.
Mouse   504 SDVEQYKLVESSETPKATKGNYIEVRTGEPQERRGCELSRPGEPQSSVAEISTIAKEVDRVNQII 568

  Fly   569 NN--KALVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTKP-----QFLS----------- 615
            ||  .||.|     :|.||    :.|..|. |....|||...::|     .|||
Mouse   569 NNCIDALKS-----ESTSF----QGAKSGA-VSAAEPQLVLLSEPLASKHSFLSPVYKDAFGHGG 623

  Fly   616 ---------------ATATVGDSCYS----YADVPMVHGAPL--------GGPNQPQLRLT---- 649
                           |:.:...|..|    .|:....|.||.        ..| .|:..||
Mouse   624 LQRHHSVEAAPGPPRASTSSSGSARSPRTFRAEATGTHKAPATETKYIEKSSP-VPETILTVTPA 687

  Fly   650 -----QEHFKQRELYDQEMGSEILDHNYIYSNTHYSMPLEQLGRSKTPTPPPMPP 699
                 .|..|.|: |.        :|.:.|..:|.:.|         |.|||.||
Mouse   688 ATVLRAEADKSRQ-YG--------EHRHSYPGSHPAEP---------PAPPPPPP 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380
		LRR_8	83..142	CDD:290566	12/44 (27%)
		leucine-rich repeat	84..107	CDD:275380	3/9 (33%)
		leucine-rich repeat	108..131	CDD:275380	4/22 (18%)
		LRR_RI	129..421	CDD:238064	83/369 (22%)
		LRR_8	132..190	CDD:290566	22/57 (39%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	6/23 (26%)
		LRR_8	203..263	CDD:290566	20/92 (22%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	12/55 (22%)
		LRR_8	252..308	CDD:290566	12/55 (22%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	3/22 (14%)
		leucine-rich repeat	301..322	CDD:275380	7/41 (17%)
		LRR_8	325..384	CDD:290566	12/58 (21%)
		leucine-rich repeat	326..350	CDD:275380	4/23 (17%)
		leucine-rich repeat	351..373	CDD:275380	5/21 (24%)
Elfn1	NP_001371115.1	LRR 1	61..82		4/20 (20%)
		leucine-rich repeat	65..85	CDD:275378	4/19 (21%)
		LRR_8	85..144	CDD:404697	22/58 (38%)
		LRR 2	85..106		8/20 (40%)
		leucine-rich repeat	86..109	CDD:275378	8/22 (36%)
		LRR 3	109..130		6/20 (30%)
		leucine-rich repeat	110..133	CDD:275378	8/22 (36%)
		LRR_8	132..182	CDD:404697	16/53 (30%)
		LRR 4	133..154		6/20 (30%)
		leucine-rich repeat	134..157	CDD:275378	6/23 (26%)
		LRR 5	157..178		5/23 (22%)
		leucine-rich repeat	158..171	CDD:275378	4/12 (33%)
		LRRCT	190..>228	CDD:214507	7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..293		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	627..674		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..731		13/46 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100