DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and FLRT3

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_037413.1	Gene:	FLRT3 / 23767	HGNCID:	3762	Length:	649	Species:	Homo sapiens

Alignment Length:	684	Identity:	160/684 - (23%)
Similarity:	246/684 - (35%)	Gaps:	197/684 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MMIAFVGIWCILASIG----VEPAAGLA-NCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRL 64
            |:.|...|:.|...||    |.|.:.:| :||..|:||..  .:.|.:..|..:|..:......|
Human     1 MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAG--FIYCNDRFLTSIPTGIPEDATTL 63

  Fly    65 VIKSNKIKT--IDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFI 127
            .:::|:|..  |.|.::...::..:.|..|.|...|.....|.|   |:||..|.|..|   |:.
Human    64 YLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVK---ELHLQENNIRTI---TYD 122

  Fly   128 GLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIG--YLDPKAFDGLSQLRILYLDDNAL 190
            .||.:..|                     |||:|.:|.:.  .::..||...:.||:|:|..|.|
Human   123 SLSKIPYL---------------------EELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHL 166

  Fly   191 TTVPDPVIFQAMP-SLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRN--ISHDSFLGLQE 252
            :|:|     ..:| ::.||.|..|.:.:|.:.:.|.|..|.||.|.|..|.|  :....|..|..
Human   167 STIP-----WGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVN 226

  Fly   253 LRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMT 317
            |..|.|..|.|...| |.|.. ..|.:|.|..|....:...||..|:||.||::
Human   227 LTELSLVRNSLTAAP-VNLPG-TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDM----------- 278

  Fly   318 GAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSEN 382
                           ||..|..:.:|....|..:..::|:.|          ||
Human   279 ---------------SNNNLSNLPQGIFDDLDNITQLILRNN----------PW----------- 307

  Fly   383 PLSCDCRVM----WLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQAL 443
              .|.|::.    ||.:|.|..|     |..|:|:.||::||.:::.||..:..|..:.
Human   308 --YCGCKMKWVRDWLQSLPVKVN-----VRGLMCQAPEKVRGMAIKDLNAELFDCKDSG------ 359

  Fly   444 IGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPC 508
                :|.:....||:...:|..:         |.|  .|...|:.:.:.....:|    ||
Human   360 ----IVSTIQITTAIPNTVYPAQ---------GQW--PAPVTKQPDIKNPKLTKD----HQ---- 401

  Fly   509 SLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVP-TATMISEKKLNNNKA 572
            :.|..|....|.|.......|.|...                  :|.:| ||..:|..||.::.|
Human   402 TTGSPSRKTITITVKSVTSDTIHISW------------------KLALPMTALRLSWLKLGHSPA 448

  Fly   573 LVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATATVGDSCYSYADVPM----- 632
            .   |:|.:         :...|.             :.::| .||...||.|....|||
Human   449 F---GSITE---------TIVTGE-------------RSEYL-VTALEPDSPYKVCMVPMETSNL 487

  Fly   633 -----------VHGAPLGGPNQPQLRLTQEHFKQ 655
                       ...|||...| |...|.:|..|:
Human   488 YLFDETPVCIETETAPLRMYN-PTTTLNREQEKE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	5/19 (26%)
		LRR_8	83..142	CDD:290566	16/58 (28%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	76/300 (25%)
		LRR_8	132..190	CDD:290566	13/59 (22%)
		leucine-rich repeat	132..155	CDD:275380	1/22 (5%)
		leucine-rich repeat	156..179	CDD:275380	7/24 (29%)
		leucine-rich repeat	180..204	CDD:275380	9/24 (38%)
		LRR_8	203..263	CDD:290566	21/62 (34%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	9/24 (38%)
		LRR_8	252..308	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	3/20 (15%)
		LRR_8	325..384	CDD:290566	9/58 (16%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	4/21 (19%)
FLRT3	NP_037413.1	LRRNT	31..61	CDD:214470	8/31 (26%)
		Interaction with ADGRL3. /evidence=ECO:0000269\|PubMed:26235030	38..67		5/30 (17%)
		LRR 1. /evidence=ECO:0000255	59..80		5/20 (25%)
		leucine-rich repeat	61..84	CDD:275378	5/22 (23%)
		LRR 2. /evidence=ECO:0000255	84..104		4/19 (21%)
		leucine-rich repeat	85..104	CDD:275380	4/18 (22%)
		LRR 3. /evidence=ECO:0000255	105..126		10/26 (38%)
		LRR_8	106..166	CDD:290566	23/86 (27%)
		leucine-rich repeat	106..129	CDD:275380	10/28 (36%)
		LRR_RI	<120..259	CDD:238064	48/166 (29%)
		LRR 4. /evidence=ECO:0000255	129..150		6/41 (15%)
		leucine-rich repeat	130..155	CDD:275380	8/45 (18%)
		LRR 5. /evidence=ECO:0000255	155..175		8/24 (33%)
		leucine-rich repeat	156..176	CDD:275380	9/24 (38%)
		LRR_8	175..237	CDD:290566	20/61 (33%)
		LRR 6. /evidence=ECO:0000255	176..197		5/20 (25%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		LRR 7. /evidence=ECO:0000255	200..220		7/19 (37%)
		leucine-rich repeat	201..226	CDD:275380	9/24 (38%)
		LRR 8. /evidence=ECO:0000255	226..247		8/22 (36%)
		leucine-rich repeat	227..248	CDD:275380	8/22 (36%)
		LRR_8	247..306	CDD:290566	18/94 (19%)
		LRR_4	247..287	CDD:289563	14/65 (22%)
		LRR 9. /evidence=ECO:0000255	248..269		6/20 (30%)
		leucine-rich repeat	249..272	CDD:275380	7/22 (32%)
		LRR 10. /evidence=ECO:0000255	272..293		8/46 (17%)
		leucine-rich repeat	273..296	CDD:275380	8/48 (17%)
		LRRCT	305..356	CDD:214507	19/78 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		5/27 (19%)
		fn3	413..478	CDD:278470	20/108 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870