DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and Lingo3

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001013780.2 Gene:Lingo3 / 237403 MGIID:3609246 Length:589 Species:Mus musculus


Alignment Length:449 Identity:119/449 - (26%)
Similarity:189/449 - (42%) Gaps:85/449 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 CILASIGVE----PAAGL-ANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKT 73
            |.|..:|:.    |.|.| |.||..|:|..:|..|.||..:|..:|..:.               
Mouse     3 CWLHMLGLHLLLLPTAPLAAGCPARCECSASTRTVACGRRRLTAIPEGIP--------------- 52

  Fly    74 IDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLR 138
                    ||...|:||.|.:..:.....|....|:|:.||||.|..:....|..|..:.||.||
Mouse    53 --------AETRMLELSRNRIRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLR 109

  Fly   139 GNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMP 203
            |||:..:..|.||.|..:..|:|.||::..|...:|..|..|:.|.:.||.|..:.... |..:.
Mouse   110 GNQLKLIPPGVFTHLDSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRA-FAGLL 173

  Fly   204 SLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFL---GLQELRI---------- 255
            .||||.|....|.|:..::...|:||..|.|:..::..:...:|.   ||..|.|          
Mouse   174 GLAELTLERCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQKLPGLSHLEIDNWPLLEEVA 238

  Fly   256 -----------LDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGA 309
                       |.::...:..:|:..|.:...|..|:|..|...::..|:|..|.:|:.|.:.||
Mouse   239 PGSLRGLNLTSLSITHTNITAVPAAALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGA 303

  Fly   310 LRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLF-PWKD 373
            |                          |..::..|..||.|::.:.|..|.|::|.|..| ....
Mouse   304 L--------------------------LAVIEPQAFVGLRQIRLLNLSDNLLSTLEENTFHSVNT 342

  Fly   374 LQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSEL-LCEFPERLRGESLRHLNPAMM 431
            |:||.:..|||:||||::|    :|.:..:.:....| .|..|..:||::|.:|..:::
Mouse   343 LETLRVDGNPLACDCRLLW----IVQRRKTLNFDGRLPACATPAEVRGDALHNLPDSVL 397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 0/17 (0%)
LRR_8 83..142 CDD:290566 21/58 (36%)
leucine-rich repeat 84..107 CDD:275380 5/22 (23%)
leucine-rich repeat 108..131 CDD:275380 9/22 (41%)
LRR_RI 129..421 CDD:238064 84/317 (26%)
LRR_8 132..190 CDD:290566 22/57 (39%)
leucine-rich repeat 132..155 CDD:275380 11/22 (50%)
leucine-rich repeat 156..179 CDD:275380 7/22 (32%)
leucine-rich repeat 180..204 CDD:275380 6/23 (26%)
LRR_8 203..263 CDD:290566 18/83 (22%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
leucine-rich repeat 229..252 CDD:275380 6/25 (24%)
LRR_8 252..308 CDD:290566 14/76 (18%)
leucine-rich repeat 253..276 CDD:275380 5/43 (12%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
leucine-rich repeat 301..322 CDD:275380 5/20 (25%)
LRR_8 325..384 CDD:290566 15/59 (25%)
leucine-rich repeat 326..350 CDD:275380 4/23 (17%)
leucine-rich repeat 351..373 CDD:275380 6/22 (27%)
Lingo3NP_001013780.2 LRRNT 23..55 CDD:214470 11/54 (20%)
leucine-rich repeat 34..53 CDD:275380 6/41 (15%)
LRR 1 54..75 5/20 (25%)
LRR <55..353 CDD:227223 85/324 (26%)
leucine-rich repeat 55..78 CDD:275380 5/22 (23%)
LRR 2 78..99 8/20 (40%)
leucine-rich repeat 79..102 CDD:275380 9/22 (41%)
LRR 3 102..123 9/20 (45%)
leucine-rich repeat 103..150 CDD:275380 18/46 (39%)
LRR 4 126..147 6/20 (30%)
LRR 5 150..171 6/21 (29%)
leucine-rich repeat 151..174 CDD:275380 6/23 (26%)
LRR 6 174..195 7/20 (35%)
leucine-rich repeat 175..198 CDD:275380 8/22 (36%)
leucine-rich repeat 199..222 CDD:275380 4/22 (18%)
LRR 7 206..227 3/20 (15%)
leucine-rich repeat 223..246 CDD:275380 3/22 (14%)
LRR_8 246..302 CDD:338972 12/55 (22%)
LRR 8 246..267 3/20 (15%)
leucine-rich repeat 247..270 CDD:275380 3/22 (14%)
LRR 9 270..291 6/20 (30%)
leucine-rich repeat 271..292 CDD:275380 6/20 (30%)
LRR 10 294..315 7/46 (15%)
leucine-rich repeat 295..318 CDD:275380 9/48 (19%)
LRR 11 318..339 7/20 (35%)
leucine-rich repeat 321..342 CDD:275380 6/20 (30%)
PCC 331..>405 CDD:188093 22/71 (31%)
I-set 406..496 CDD:369462
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6410
SonicParanoid 1 1.000 - - X1280
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.040

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