DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Nyx

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_775591.1	Gene:	Nyx / 236690	MGIID:	2448607	Length:	476	Species:	Mus musculus

Alignment Length:	455	Identity:	120/455 - (26%)
Similarity:	179/455 - (39%)	Gaps:	82/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AGLANCPPGCQCD--DNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFL 87
            |.|..||..|.|.  :....|:|....|..:|                       .:|..|...:
Mouse    21 ACLRACPAACTCSHVERGCSVRCDRAGLQRVP-----------------------QEFPCEAASI 62

  Fly    88 DLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTP 152
            ||..|.|..:.:|.|.....|:.:.|.||           .||.:|             .|.|..
Mouse    63 DLDRNGLRILGERAFGTLPSLRRLSLRHN-----------NLSFIT-------------PGAFKG 103

  Fly   153 LLKIEELNLGEN-RIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQ 216
            |.::.||.|..| .:.||..:.|..|.:||.|.|....|.:||:.::.: :|:|.||....|..:
Mouse   104 LPRLAELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPERLLAE-LPALRELTAFDNLFR 167

  Fly   217 SIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLS 281
            .:.. |.:.|..||....:.:.:..::..|.||::.||.|.|..||:..:.:........||.|.
Mouse   168 RVPG-ALRGLANLTHAHFERSRIEAVASGSLLGMRRLRSLSLQANRVRAVHAGAFGDCGALEDLL 231

  Fly   282 LGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALS 346
            |..|....:...||.||::|:.|.:.|. .|..|....|||...||.|.|..|.:.. |:|||..
Mouse   232 LNDNLLATLPAAAFRGLRRLRTLNLGGN-ALGSVARAWFSDLAELELLYLDRNSITF-VEEGAFQ 294

  Fly   347 GLSQLKHVVLKANALTSLAEGLF-PWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSEL 410
            .||.|..:.|..|.||.|:...| |...|..|.|..||..|||::.||.:.:.....    |:::
Mouse   295 NLSGLLALHLNGNRLTVLSWAAFQPGFFLGRLFLFRNPWRCDCQLEWLRDWMEGSGR----VADV 355

  Fly   411 LCEFPERLRGESLRH-----------LNPAMMGCTHADP------------RKQALIGALLVGSA 452
            .|..|..:.|:.|..           ::|..:..|.:.|            |..:|:..||...|
Mouse   356 ACASPGSVAGQDLSQVVFERSSDGLCVDPDELNFTTSSPGPSPEPVATTVSRFSSLLSKLLAPRA 420

Fly 453 452
Mouse 421 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	0/17 (0%)
		LRR_8	83..142	CDD:290566	14/58 (24%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_RI	129..421	CDD:238064	88/293 (30%)
		LRR_8	132..190	CDD:290566	16/58 (28%)
		leucine-rich repeat	132..155	CDD:275380	4/22 (18%)
		leucine-rich repeat	156..179	CDD:275380	8/23 (35%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	17/59 (29%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..308	CDD:290566	17/55 (31%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		LRR_8	325..384	CDD:290566	23/59 (39%)
		leucine-rich repeat	326..350	CDD:275380	10/23 (43%)
		leucine-rich repeat	351..373	CDD:275380	8/22 (36%)
Nyx	NP_775591.1	LRRNT	25..56	CDD:214470	8/53 (15%)
		LRR 1	58..79		7/20 (35%)
		LRR_8	61..115	CDD:338972	19/77 (25%)
		leucine-rich repeat	63..82	CDD:275380	6/18 (33%)
		LRR_RI	<68..312	CDD:393385	79/271 (29%)
		LRR 2	82..103		9/44 (20%)
		leucine-rich repeat	83..106	CDD:275380	10/46 (22%)
		LRR 3	106..128		7/21 (33%)
		leucine-rich repeat	107..131	CDD:275380	8/23 (35%)
		LRR 4	131..154		7/23 (30%)
		leucine-rich repeat	132..155	CDD:275380	7/23 (30%)
		LRR 5	155..177		5/22 (23%)
		leucine-rich repeat	156..178	CDD:275380	6/22 (27%)
		LRR 6	178..199		3/20 (15%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		LRR 7	202..223		6/20 (30%)
		leucine-rich repeat	203..226	CDD:275380	6/22 (27%)
		LRR 8	226..247		7/20 (35%)
		leucine-rich repeat	227..250	CDD:275380	9/22 (41%)
		LRR_8	250..309	CDD:338972	22/60 (37%)
		LRR 9	250..271		6/21 (29%)
		leucine-rich repeat	251..274	CDD:275380	8/23 (35%)
		LRR 10	274..295		9/21 (43%)
		leucine-rich repeat	275..296	CDD:275380	9/21 (43%)
		LRR 11	298..319		7/20 (35%)
		leucine-rich repeat	299..322	CDD:275378	8/22 (36%)
		leucine-rich repeat	323..335	CDD:275378	5/11 (45%)
		LRRCT	331..>366	CDD:214507	10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010