DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and lron-1

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_510424.4 Gene:lron-1 / 181553 WormBaseID:WBGene00008093 Length:607 Species:Caenorhabditis elegans


Alignment Length:532 Identity:129/532 - (24%)
Similarity:203/532 - (38%) Gaps:96/532 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LNPSIQRLVIKSNKIKTI-DSSIQFYAELTFLDLSSNHLMTIPQRTF-AYQKK--LQEVHLNHNK 117
            |..|::.|.|:.|.|..| .|.:....:|..|.|..|.:..:....| :|..:  |.::.|:.|.
 Worm   106 LENSLEELEIRGNYIDGIPQSGVSILKQLKILSLPDNLIEYVQDNAFLSYHSRDSLLKLDLSANN 170

  Fly   118 IGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRI 182
            :..|.....:||..::.|:|..|.:||:.......:..:|:|:||.|||..:...:.. |..|:.
 Worm   171 LTAIHPTGLLGLENLSQLSLDKNLLSEIPSQALENIPSLEDLSLGVNRIHTISRNSLP-LPNLKS 234

  Fly   183 LYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLEL-KGASLRNISHDS 246
            |.|:.|.:..:|.. .|...|.|:.|:||.|.|.||.|..|..:.||..|.: ....:.:|..:.
 Worm   235 LSLEVNQIRLIPSD-SFSETPLLSYLYLGNNLLTSIDASMFLHIGGLKVLSMSNNKDITSIQANG 298

  Fly   247 FLGLQELRI---------------LDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFM 296
            .|.:|:.::               |:|.|..:.||....|.|:..::.:.|.:|....||...|.
 Worm   299 KLSVQQFKLCICILAFQHAPSLIRLELFDCSISRIEPKSLQKVQHIQVILLSRNQITRISHDTFS 363

  Fly   297 GLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANAL 361
            .|.:|..|:::|. .:..|...|||....|..|:||||::...........|.|.|         
 Worm   364 NLPELSELDLSGN-SINAVDDFAFSQLPMLTSLDLSSNRLESLPSNVIYDSLMQKK--------- 418

  Fly   362 TSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLL-----VAKNASQDDVSELLCEFPERLRGE 421
            ||..:        :.|.:..||..||..:|||...|     |...||....::  |..|..|.|.
 Worm   419 TSPVQ--------RKLSIQNNPWRCDKDLMWLRKWLRDNGDVTTAASNSPPAK--CWTPSNLSGL 473

  Fly   422 SLRHLNPAMMGCT-----------------------------HADPRKQALIGALLVGSAATITA 457
            .||..:..:...|                             |.:....||:| |::|....:..
 Worm   474 DLRQTDSKLPHKTTKPPVDQFQYKNQQVTNSNGTSQLGYQNPHTEVNGLALVG-LILGIVLVVFV 537

  Fly   458 LALVL-YRCRH-------KIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHS 514
            ..::| |..|.       |.:..:.|....:|...|.......|...||:     .||.|..   
 Worm   538 SCIILGYLMRFIFLSYEAKTKPNVFGSTISSSGCIRNMYGGDGTLVSEDH-----GHPSSAN--- 594

  Fly   515 TFPNTY-TAPHH 525
              .|.| ..|.|
 Worm   595 --NNVYLNRPRH 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 6/18 (33%)
LRR_8 83..142 CDD:290566 15/61 (25%)
leucine-rich repeat 84..107 CDD:275380 6/23 (26%)
leucine-rich repeat 108..131 CDD:275380 6/22 (27%)
LRR_RI 129..421 CDD:238064 83/312 (27%)
LRR_8 132..190 CDD:290566 17/57 (30%)
leucine-rich repeat 132..155 CDD:275380 5/22 (23%)
leucine-rich repeat 156..179 CDD:275380 8/22 (36%)
leucine-rich repeat 180..204 CDD:275380 6/23 (26%)
LRR_8 203..263 CDD:290566 20/75 (27%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 4/23 (17%)
LRR_8 252..308 CDD:290566 15/70 (21%)
leucine-rich repeat 253..276 CDD:275380 7/37 (19%)
leucine-rich repeat 277..300 CDD:275380 6/22 (27%)
leucine-rich repeat 301..322 CDD:275380 6/20 (30%)
LRR_8 325..384 CDD:290566 13/58 (22%)
leucine-rich repeat 326..350 CDD:275380 7/23 (30%)
leucine-rich repeat 351..373 CDD:275380 3/21 (14%)
lron-1NP_510424.4 PRK15370 <58..>289 CDD:185268 53/184 (29%)
leucine-rich repeat 85..109 CDD:275380 1/2 (50%)
leucine-rich repeat 110..133 CDD:275380 6/22 (27%)
leucine-rich repeat 134..157 CDD:275380 6/22 (27%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
leucine-rich repeat 185..208 CDD:275380 5/22 (23%)
leucine-rich repeat 209..231 CDD:275380 8/22 (36%)
leucine-rich repeat 232..255 CDD:275380 6/23 (26%)
leucine-rich repeat 256..279 CDD:275380 10/22 (45%)
leucine-rich repeat 280..319 CDD:275380 5/38 (13%)
leucine-rich repeat 320..343 CDD:275380 7/22 (32%)
LRR_8 343..402 CDD:338972 19/59 (32%)
leucine-rich repeat 344..367 CDD:275380 6/22 (27%)
leucine-rich repeat 368..391 CDD:275380 7/23 (30%)
leucine-rich repeat 392..410 CDD:275380 6/17 (35%)
leucine-rich repeat 414..435 CDD:275378 8/37 (22%)
LRRCT 431..>472 CDD:214507 14/42 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D187891at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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