DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and lron-2

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_505402.1 Gene:lron-2 / 179309 WormBaseID:WBGene00022789 Length:575 Species:Caenorhabditis elegans


Alignment Length:624 Identity:144/624 - (23%)
Similarity:238/624 - (38%) Gaps:162/624 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ILASI-----GVEPA-AGLANCPPG--------CQ----CDDNTLVVQCGE----GQLDVLPIAL 57
            |||::     |..|| :|...|.|.        ||    ..:....:|...    ..|.:|..|:
 Worm     7 ILATLVVTVYGQCPALSGACRCAPSVYEPVAIICQNAGSLQNAIQAIQAARDIPIDSLTILDTAI 71

  Fly    58 NPSIQ----------RLVIKSNKIKTIDSSI---QFYAELTFLDLSSNHLMTIPQRTFAYQKKLQ 109
             |:|.          |||:..|.::.||...   .....|..|||:.|:|..|||......:.|:
 Worm    72 -PTIPANAFQSFTILRLVLNRNTLQNIDDQAFNGPLLDSLIELDLNDNNLGQIPQTGIPRLRNLR 135

  Fly   110 EVHLNHNKIGQISNKTFIGLSA---VTVLNLRGNQISELHQG---TFTPLLKIEELNLGENRIGY 168
            :::||.|:|.|:|:..|....:   :..|.|.||::::...|   .|.||..::||:        
 Worm   136 KLYLNRNRINQLSSTAFNAFESRDLLLKLELAGNRLTDATLGDATVFRPLTLLQELS-------- 192

  Fly   169 LDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLE 233
                            |:.|:||::|...:.....:|..|.||:|::..:...|. |...|:.|.
 Worm   193 ----------------LETNSLTSIPSSALVNQRNTLTNLNLGLNSINEVPVGAL-DFPVLSSLS 240

  Fly   234 LKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGL 298
            |:...:..|...:|.|:..|:.|.::.|:...........:.:|:.|.:|:....||...|||.:
 Worm   241 LEFNGITVIPPQAFQGVPNLQFLYMTGNKFPSWAPEMFRYITQLKTLGIGETPISVIPNNAFMHI 305

  Fly   299 KQLKRLEVNGAL-----------------------RLKRVMTGAFSDNGNLEYLNLSSNKMLLEV 340
            ..|.|||::.|.                       ||.:|....|....:|..::|..|: :..|
 Worm   306 PNLIRLEMSEAAVDTIERGAFQRTPQIQAIVLNKNRLSQVRADFFEGLNDLYSIDLQGNR-IDNV 369

  Fly   341 QEGALSGLSQLKHVVLKANALTSLAEGLF-------PWKDLQTLDLSENPLSCDCRVMWLHNLLV 398
            |....:.|..:.|:.:..|.|.::...:|       | .|.:.:....||..|:..:.|...|| 
 Worm   370 QPLGFANLPAISHLDISYNLLQTMPSNVFQNSFLPQP-NDRRVIYACGNPWYCNSELEWFRTLL- 432

  Fly   399 AKNASQDDVSELLC-----EFPE--RLRGESLRHLNPAMMGCTH---ADP---RKQALIGALLVG 450
             ::....||.:..|     ..|.  .:.|..||.::    .|.:   |.|   |..:::|.:::.
 Worm   433 -RDNLDIDVEKPGCTAVCTSSPNGCPVEGTPLRSVD----FCQNNEEAQPLVGRALSMVGWIILA 492

  Fly   451 SAAT-----ITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSL 510
            ...|     |..||:|.|...|                   :|:.||   |.:..:...||    
 Worm   493 VIMTILLISICLLAMVRYGMSH-------------------QRKKQK---DAEVAAEEYHH---- 531

  Fly   511 GIHSTFPNTYTAP----HHPGATHHYGMCPMPVN-DLGA 544
              .:|..:.|.||    ..|     |...| ||| ||.|
 Worm   532 --QTTATSIYNAPISVVDRP-----YSTVP-PVNLDLPA 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 6/30 (20%)
LRR_8 83..142 CDD:290566 21/61 (34%)
leucine-rich repeat 84..107 CDD:275380 9/22 (41%)
leucine-rich repeat 108..131 CDD:275380 8/22 (36%)
LRR_RI 129..421 CDD:238064 70/334 (21%)
LRR_8 132..190 CDD:290566 12/60 (20%)
leucine-rich repeat 132..155 CDD:275380 8/25 (32%)
leucine-rich repeat 156..179 CDD:275380 2/22 (9%)
leucine-rich repeat 180..204 CDD:275380 5/23 (22%)
LRR_8 203..263 CDD:290566 16/59 (27%)
leucine-rich repeat 205..228 CDD:275380 7/22 (32%)
leucine-rich repeat 229..252 CDD:275380 6/22 (27%)
LRR_8 252..308 CDD:290566 15/55 (27%)
leucine-rich repeat 253..276 CDD:275380 3/22 (14%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
leucine-rich repeat 301..322 CDD:275380 9/43 (21%)
LRR_8 325..384 CDD:290566 13/65 (20%)
leucine-rich repeat 326..350 CDD:275380 6/23 (26%)
leucine-rich repeat 351..373 CDD:275380 5/28 (18%)
lron-2NP_505402.1 leucine-rich repeat 64..84 CDD:275380 5/20 (25%)
leucine-rich repeat 85..109 CDD:275380 6/23 (26%)
LRR_8 86..144 CDD:290566 19/57 (33%)
LRR_RI 109..294 CDD:238064 51/209 (24%)
leucine-rich repeat 110..133 CDD:275380 9/22 (41%)
LRR_8 132..198 CDD:290566 20/89 (22%)
leucine-rich repeat 134..157 CDD:275380 8/22 (36%)
leucine-rich repeat 161..187 CDD:275380 8/25 (32%)
leucine-rich repeat 188..211 CDD:275380 7/46 (15%)
LRR_8 212..270 CDD:290566 16/58 (28%)
leucine-rich repeat 213..235 CDD:275380 7/22 (32%)
leucine-rich repeat 236..259 CDD:275380 6/22 (27%)
leucine-rich repeat 260..283 CDD:275380 3/22 (14%)
LRR_8 282..342 CDD:290566 13/59 (22%)
leucine-rich repeat 284..307 CDD:275380 8/22 (36%)
leucine-rich repeat 308..355 CDD:275380 9/46 (20%)
LRR_8 330..390 CDD:290566 12/60 (20%)
leucine-rich repeat 356..377 CDD:275380 5/21 (24%)
leucine-rich repeat 380..400 CDD:275380 4/19 (21%)
Ca_hom_mod <481..>504 CDD:291464 4/22 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D187891at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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