DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and lron-11

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_491035.1	Gene:	lron-11 / 171837	WormBaseID:	WBGene00022129	Length:	542	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	138/555 - (24%)
Similarity:	232/555 - (41%)	Gaps:	109/555 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDL 89
            :|:.:|..||:|...|..| |....|..:||.|:|                       ..|.|||
Worm    13 SGVISCQSGCKCPTKTTAV-CKGSSLRSIPILLDP-----------------------RTTVLDL 53

  Fly    90 SSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLL 154
            |:|.:..:.....:....|:::.|::|.|..:|...|..|.::.||:|..|.:..|....|:.|.
Worm    54 SNNRISRLSADELSLYPNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLPNEVFSKLK 118

  Fly   155 KIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQ 219
            .::.|.:..|.: .|.|:.|.|||||:.|.:.||.|:.:| |.:.:.:..|..|.|..|.|.|:.
Worm   119 NLKTLIISSNDV-QLGPECFAGLSQLQTLSIADNRLSFLP-PSVLKPLSGLRNLDLSANKLLSMP 181

  Fly   220 ADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDN-----------RLDRIPSVGL-- 271
            |....:|.||..|:||...|.::....||..:||:.||:|:|           .|:::.::.|
Worm   182 ASVMNNLGGLETLKLKQNLLSSLETGMFLSQKELKHLDVSENLIGDIEEGALYGLEKLETLNLTN 246

  Fly   272 SKLVR----------LEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNL 326
            ::|||          |:.|.|..|.|..:...:|.||..|:.|.::.:..||.:....|....:|
Worm   247 NQLVRLPGNTWSLPALKTLDLSSNLFVSLETASFDGLPALQYLNISHSRNLKTIQMATFVQLSSL 311

  Fly   327 EYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVM 391
            .:|::||: .|..:...|.:.:..|.|:.|..|.|..:|.|:..|.:::.|.|:.|...|.|
Worm   312 HWLSISSS-ALTHIHPSAFNPIPPLSHLDLSNNELRYVAPGMLQWPNIRNLHLANNDWHCSC--- 372

  Fly   392 WLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGALLVGSAAT-- 454
               :|.|:....:||..   |..||.|.|..:..|:    .|        :::|.||:.....
Worm   373 ---DLRVSNLNPRDDAK---CSGPENLAGAPINELS----SC--------SILGGLLIPFLLVLF 419

  Fly   455 --ITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTF- 516
              :.||.::...|:.....::|...:.|               |:...:.:.|...|...||.:
Worm   420 ILLLALVILALACKKSKPVSLKNRAFYN---------------DQLIAALNSHKEYSFDCHSPYT 469

  Fly   517 -------------PNTYTAPHHPGATHHYGMCPMP 538
                         |.:...|..|..:     ||.|
Worm   470 MSSEDSRDSAYESPTSALMPRRPPPS-----CPPP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	0/17 (0%)
		LRR_8	83..142	CDD:290566	17/58 (29%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	91/314 (29%)
		LRR_8	132..190	CDD:290566	20/57 (35%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	22/70 (31%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	21/78 (27%)
		leucine-rich repeat	253..276	CDD:275380	8/35 (23%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	17/58 (29%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	8/21 (38%)
lron-11	NP_491035.1	leucine-rich repeat	48..71	CDD:275380	6/22 (27%)
		LRR_RI	<50..177	CDD:238064	39/128 (30%)
		LRR_8	70..130	CDD:290566	16/59 (27%)
		leucine-rich repeat	72..95	CDD:275380	7/22 (32%)
		leucine-rich repeat	96..119	CDD:275380	7/22 (32%)
		LRR_8	118..177	CDD:290566	20/60 (33%)
		leucine-rich repeat	120..142	CDD:275380	7/22 (32%)
		LRR_RI	<141..270	CDD:238064	39/129 (30%)
		leucine-rich repeat	143..166	CDD:275380	7/23 (30%)
		leucine-rich repeat	167..190	CDD:275380	8/22 (36%)
		LRR_8	190..249	CDD:290566	16/58 (28%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		LRR_8	238..295	CDD:290566	14/56 (25%)
		leucine-rich repeat	239..261	CDD:275380	4/21 (19%)
		leucine-rich repeat	262..283	CDD:275380	6/20 (30%)
		LRR_8	284..345	CDD:290566	15/61 (25%)
		leucine-rich repeat	286..310	CDD:275380	5/23 (22%)
		leucine-rich repeat	311..334	CDD:275380	6/23 (26%)
		leucine-rich repeat	335..357	CDD:275380	8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BG7P
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14510
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740