DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Lrrn2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_034862.1	Gene:	Lrrn2 / 16980	MGIID:	106037	Length:	730	Species:	Mus musculus

Alignment Length:	458	Identity:	129/458 - (28%)
Similarity:	199/458 - (43%)	Gaps:	61/458 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CPPGCQCD-----------DNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTID-SSIQFYA 82
            |||.|.|.           .....|.|.:..|..:|..|....|.|:::||.|..|| :.:.:.|
Mouse    29 CPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPRLPAGTQTLLLQSNSISRIDQTELAYLA 93

  Fly    83 ELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQ 147
            .||.||||.|.........|....:|..:||..|::.::.:.:|.||::
Mouse    94 NLTELDLSQNSFSDARDCDFQALPQLLSLHLEENRLNRLEDHSFAGLTS---------------- 142

  Fly   148 GTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGM 212
                    ::||.|..|::..:.|:||.||..|..|:|:.|.|.|: |...|:.:|:|..|.:|.
Mouse   143 --------LQELYLNHNQLCRISPRAFAGLGNLLRLHLNSNLLRTI-DSRWFEMLPNLEILMIGG 198

  Fly   213 NTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRL 277
            |.:.:|....|:.|..|..|.|.|.|||.||..:..|||.|..|...||:|.::|...|.::..|
Mouse   199 NKVDAILDMNFRPLANLRSLVLAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGL 263

  Fly   278 EQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQE 342
            :.|.|.:|..:.:..|.|..:..||.|.:|....|..:...|..:...|..|::::|..|..:..
Mouse   264 KFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHP 328

  Fly   343 GALSGLSQLKHVVLKANALTSL----AEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNAS 403
            .|...|.|::.::|..|||::|    .|.|   .:||.:.|..||:.|||.:.|       .||:
Mouse   329 RAFHHLPQMETLMLNNNALSALHQQTVESL---PNLQEVGLHGNPIRCDCVIRW-------ANAT 383

  Fly   404 QDDV-----SELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLY 463
            ...|     ...||..|..|:...:|.: |......|..|    ||......|:..|.:....:.
Mouse   384 GTHVRFIEPQSTLCAEPPDLQRRPVREV-PFREMTDHCLP----LISPRSFPSSLQIASGESTVL 443

  Fly   464 RCR 466
            .||
Mouse   444 HCR 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	7/18 (39%)
		LRR_8	83..142	CDD:290566	15/58 (26%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	87/300 (29%)
		LRR_8	132..190	CDD:290566	13/57 (23%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	24/59 (41%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	11/22 (50%)
		LRR_8	252..308	CDD:290566	16/55 (29%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		LRR_8	325..384	CDD:290566	18/62 (29%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	7/25 (28%)
Lrrn2	NP_034862.1	leucine-rich repeat	51..69	CDD:275380	5/17 (29%)
		LRR_RI	62..288	CDD:238064	75/250 (30%)
		leucine-rich repeat	71..94	CDD:275380	7/22 (32%)
		leucine-rich repeat	95..118	CDD:275380	8/22 (36%)
		LRR_8	117..177	CDD:290566	20/83 (24%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..222	CDD:290566	19/56 (34%)
		leucine-rich repeat	167..190	CDD:275380	8/23 (35%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		LRR_RI	214..>372	CDD:238064	50/160 (31%)
		LRR_8	214..273	CDD:290566	23/58 (40%)
		leucine-rich repeat	215..238	CDD:275380	11/22 (50%)
		leucine-rich repeat	239..262	CDD:275380	7/22 (32%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		leucine-rich repeat	287..311	CDD:275380	6/23 (26%)
		LRR_8	310..371	CDD:290566	18/63 (29%)
		leucine-rich repeat	312..334	CDD:275380	5/21 (24%)
		leucine-rich repeat	337..360	CDD:275378	7/25 (28%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		TPKR_C2	369..412	CDD:301599	14/50 (28%)
		I-set	430..514	CDD:254352	4/17 (24%)
		Ig	438..514	CDD:299845	2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H21274
Inparanoid	1	1.050	159	1.000	Inparanoid score	I4234
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8753
orthoMCL	1	0.900	-	-		OOG6_103993
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960