Protein Alignment trn and LINGO2

DIOPT Version :9

• Sequence 1: NP_001261796.1
• Gene: trn / 39491
• FlyBaseID: FBgn0010452
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001245211.1
• Gene: LINGO2 / 158038
• HGNCID: 21207
• Length: 606
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 145/621 - (23%)
• Similarity: 244/621 - (39%)
• Gaps: 128/621 - (20%)

  Fly     9 FVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKT 73
            |:|:..:|..:|     ....||..|:|......|.|...:|..:|..:....:.|.:..|::|:
Human    12 FLGLAVVLIFMG-----STIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKS 71

  Fly    74 IDSSIQF--YAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLN 136
            ::.. :|  |..|..:|||.|.:..:....|.....|:.:.|..|::..:....|.|||.:|.|:
Human    72 VNPE-EFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLD 135

  Fly   137 LRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQA 201
            :..|:|..|....|..|..::.|.:|:|.:.|:..:||.||..|..|.|:...||.||...: ..
Human   136 ISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEAL-SH 199

  Fly   202 MPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRN-ISHDSFLGLQELRILDLSDNRLDR 265
            :.||..|.|....:.::...||:.|..|..||:....|.: :..:|..|| .|..|.:::..|..
Human   200 LRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLST 263

  Fly   266 IPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLN 330
            :|.:....||.|..|:|..|....|..|.|..|.:|:.|.:.|| :|:.:...:|.....|..||
Human   264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGA-QLRTIEPHSFQGLRFLRVLN 327

  Fly   331 LSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHN 395
            :|.|  |||               .|:.|..:|      | :.|:.|.::.|||:||||::|
Human   328 VSQN--LLE---------------TLEENVFSS------P-RALEVLSINNNPLACDCRLLW--- 365

  Fly   396 LLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALAL 460
            :|..:...|....:.:|..|:.:|..|.:..:.                           |||:.
Human   366 ILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHS---------------------------TALSF 403

  Fly   461 VLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHH 525
            .....:.|||                |::.|....||....:.:   ||....
Human   404 YFTCKKPKIR----------------EKKLQHLLVDEGQTVQLE---CSADGD------------ 437

  Fly   526 PGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATMISEKKLNNNKALVSQGAID-------DSA 583
                      |.||  :..:.|:::|    :.|       |.|....::..|.::       ||.
Human   438 ----------PQPV--ISWVTPRRRF----ITT-------KSNGRATVLGDGTLEIRFAQDQDSG 479

  Fly   584 SFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATAT 619
            .:|. :.|...|.|....:..:..:...:||.|..|
Human   480 MYVC-IASNAAGNDTFTASLTVKGFASDRFLYANRT 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	3/17 (18%)
		LRR_8	83..142	CDD:290566	16/58 (28%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	85/292 (29%)
		LRR_8	132..190	CDD:290566	18/57 (32%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	16/60 (27%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	7/23 (30%)
		LRR_8	252..308	CDD:290566	16/55 (29%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		LRR_8	325..384	CDD:290566	15/58 (26%)
		leucine-rich repeat	326..350	CDD:275380	8/23 (35%)
		leucine-rich repeat	351..373	CDD:275380	4/21 (19%)
LINGO2	NP_001245211.1	LRRNT	27..60	CDD:214470	8/32 (25%)
		leucine-rich repeat	39..57	CDD:275380	4/17 (24%)
		LRR 1	58..79		4/21 (19%)
		leucine-rich repeat	59..82	CDD:275380	5/23 (22%)
		LRR_8	60..117	CDD:316378	14/57 (25%)
		LRR 2	82..103		6/20 (30%)
		leucine-rich repeat	83..106	CDD:275380	6/22 (27%)
		LRR_8	106..165	CDD:316378	17/58 (29%)
		LRR 3	106..127		4/20 (20%)
		leucine-rich repeat	107..130	CDD:275380	6/22 (27%)
		LRR 4	130..151		6/20 (30%)
		leucine-rich repeat	131..154	CDD:275380	7/22 (32%)
		LRR_5	146..276	CDD:331043	37/131 (28%)
		LRR 5	154..175		6/20 (30%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR 6	178..199		7/21 (33%)
		leucine-rich repeat	179..202	CDD:275380	7/23 (30%)
		LRR 7	202..223		6/20 (30%)
		leucine-rich repeat	203..250	CDD:275380	13/47 (28%)
		LRR 8	226..247		5/20 (25%)
		LRR_8	250..309	CDD:316378	18/59 (31%)
		LRR 9	250..271		4/20 (20%)
		leucine-rich repeat	251..274	CDD:275380	5/22 (23%)
		LRR 10	274..295		7/20 (35%)
		leucine-rich repeat	275..298	CDD:275380	8/22 (36%)
		LRR_8	298..357	CDD:316378	21/83 (25%)
		LRR 11	298..319		6/21 (29%)
		leucine-rich repeat	299..322	CDD:275380	6/23 (26%)
		LRR 12	322..343		10/37 (27%)
		leucine-rich repeat	323..343	CDD:275380	10/36 (28%)
		PCC	327..>391	CDD:188093	25/90 (28%)
		I-set	410..500	CDD:254352	24/144 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8524
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010