DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and CHADL

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:XP_011528235.1 Gene:CHADL / 150356 HGNCID:25165 Length:830 Species:Homo sapiens


Alignment Length:771 Identity:158/771 - (20%)
Similarity:219/771 - (28%) Gaps:344/771 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPS-----------IQRLVIKSNKIKT 73
            |:....| .:|..|..|                 |.|..|.           .|||.::.|.:|.
Human    98 GLRAVEG-GSCQAGTAC-----------------PCAAPPGWTSSSRRHGGLTQRLDLQGNLLKV 144

  Fly    74 IDSS-----------------IQFYAE--------LTFLDLSSNHLMTIPQRTFAYQKKLQEVHL 113
            |.::                 ::..||        |..|:|:||||..:||........|:.:.|
Human   145 IPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLEL 209

  Fly   114 NHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLS 178
            ..|.:.::...||..|.|:..|||..|.:..|....|..||::..|.|..|.:..|.|:|..||.
Human   210 EGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLP 274

  Fly   179 QLRILYLDDNALTTVPDPVIFQ-----------------------AMPSLAELFLGMNTLQSIQA 220
            .||.|.|..|.|..:|.||:.|                       |:|.|.||.|....||::..
Human   275 ALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGP 339

  Fly   221 DAFQ--------DLKG--------------LTRLELKG--------------------------- 236
            .||.        ||:|              |.||.|:|                           
Human   340 RAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGAC 404

  Fly   237 ---ASLRNISHDSF--------------------------------------------------- 247
               ..||..:.|:.                                                   
Human   405 QGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACV 469

  Fly   248 ------------LGLQ--------ELRILDLSDNRLDRIPSV---GLSKLV-------------- 275
                        .|||        :.::|||..|....:|..   ||..||              
Human   470 CVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEA 534

  Fly   276 -------RLEQLSLGQNDFEVIS----EGA----FMGLKQLKRLEVNGAL--------------- 310
                   ||..|.|..|....:|    |||    ::.|::.:.|:|.||.               
Human   535 GALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDN 599

  Fly   311 ------------------------RLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQL 351
                                    |:..|..||......||.|:|..|: |.||..|||.||..|
Human   600 AVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQ-LREVPTGALEGLPAL 663

  Fly   352 KHVVLKANALTSLAEGLF----------------------------------------------- 369
            ..:.|..|.|.:|.:|.|                                               
Human   664 LELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA 728

  Fly   370 --PWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMG 432
              ....|:.:|||.||..|||:::.||..|...|....    ..|..|...||:.::........
Human   729 LPSLSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRVG----ATCATPPNARGQRVKAAAAVFED 789

  Fly   433 CTHADPRKQALIGALLVGSAATITALALVLYRCRHKIRET-IKGGLWGNSALGRKE 487
            |.....||.....|                  .|...|.| |||...|...:|:::
Human   790 CPGWAARKAKRTPA------------------SRPSARRTPIKGRQCGADKVGKEK 827

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 6/34 (18%)
LRR_8 83..142 CDD:290566 21/66 (32%)
leucine-rich repeat 84..107 CDD:275380 9/22 (41%)
leucine-rich repeat 108..131 CDD:275380 6/22 (27%)
LRR_RI 129..421 CDD:238064 115/557 (21%)
LRR_8 132..190 CDD:290566 21/57 (37%)
leucine-rich repeat 132..155 CDD:275380 7/22 (32%)
leucine-rich repeat 156..179 CDD:275380 8/22 (36%)
leucine-rich repeat 180..204 CDD:275380 11/46 (24%)
LRR_8 203..263 CDD:290566 27/182 (15%)
leucine-rich repeat 205..228 CDD:275380 10/30 (33%)
leucine-rich repeat 229..252 CDD:275380 11/123 (9%)
LRR_8 252..308 CDD:290566 21/87 (24%)
leucine-rich repeat 253..276 CDD:275380 9/46 (20%)
leucine-rich repeat 277..300 CDD:275380 9/30 (30%)
leucine-rich repeat 301..322 CDD:275380 8/59 (14%)
LRR_8 325..384 CDD:290566 25/107 (23%)
leucine-rich repeat 326..350 CDD:275380 13/23 (57%)
leucine-rich repeat 351..373 CDD:275380 7/70 (10%)
CHADLXP_011528235.1 leucine-rich repeat 132..155 CDD:275380 6/22 (27%)
LRR_RI <133..358 CDD:238064 63/224 (28%)
LRR_8 133..214 CDD:290566 20/80 (25%)
leucine-rich repeat 156..179 CDD:275380 2/22 (9%)
leucine-rich repeat 180..203 CDD:275380 9/22 (41%)
leucine-rich repeat 204..227 CDD:275380 6/22 (27%)
LRR_8 228..286 CDD:290566 21/57 (37%)
leucine-rich repeat 228..251 CDD:275380 7/22 (32%)
leucine-rich repeat 252..275 CDD:275380 8/22 (36%)
leucine-rich repeat 276..299 CDD:275380 10/22 (45%)
leucine-rich repeat 300..323 CDD:275380 1/22 (5%)
LRR_8 322..380 CDD:290566 17/57 (30%)
leucine-rich repeat 324..347 CDD:275380 8/22 (36%)
LRR_4 346..>380 CDD:289563 8/33 (24%)
LRRNT 463..497 CDD:214470 3/33 (9%)
leucine-rich repeat 478..494 CDD:275380 3/15 (20%)
LRR_RI 492..671 CDD:238064 42/179 (23%)
leucine-rich repeat 495..518 CDD:275380 7/22 (32%)
LRR_8 518..577 CDD:290566 12/58 (21%)
leucine-rich repeat 519..542 CDD:275380 2/22 (9%)
leucine-rich repeat 543..566 CDD:275380 8/22 (36%)
LRR_8 565..625 CDD:290566 5/59 (8%)
leucine-rich repeat 567..590 CDD:275380 5/22 (23%)
leucine-rich repeat 591..614 CDD:275380 0/22 (0%)
leucine-rich repeat 615..638 CDD:275380 4/22 (18%)
LRR_8 637..698 CDD:290566 20/61 (33%)
leucine-rich repeat 639..662 CDD:275380 13/23 (57%)
leucine-rich repeat 663..687 CDD:275380 7/23 (30%)
LRR_8 686..745 CDD:290566 5/58 (9%)
leucine-rich repeat 688..712 CDD:275380 0/23 (0%)
LRR_4 711..>744 CDD:289563 4/32 (13%)
LRRCT 743..791 CDD:214507 13/51 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

Return to query results.
Submit another query.