DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and RTN4RL1

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_848663.1 Gene:RTN4RL1 / 146760 HGNCID:21329 Length:441 Species:Homo sapiens


Alignment Length:580 Identity:124/580 - (21%)
Similarity:182/580 - (31%) Gaps:229/580 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ILASIGVE-PAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSI 78
            :|..:..| |..|  .||..|.|....:.|.|.......:|..:               .:||  
Human    11 LLLLVAAELPLGG--GCPRDCVCYPAPMTVSCQAHNFAAIPEGI---------------PVDS-- 56

  Fly    79 QFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQIS 143
                                          :.|.|.:|:||.:....|  ..|:..|.:..|.|:
Human    57 ------------------------------ERVFLQNNRIGLLQPGHF--SPAMVTLWIYSNNIT 89

  Fly   144 ELHQGTFTPLLKIEELNLGENR-IGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAE 207
            .:|..||...:.:|||:||:|| :..|.|:.|.||.:|..|||....|:.:|..| |..:.||..
Human    90 YIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGV-FGGLHSLQY 153

  Fly   208 LFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLS 272
            |:|..|.::.:|.|.|.||..|:.|.|.|..|.::...:|.|                       
Human   154 LYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRG----------------------- 195

  Fly   273 KLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKML 337
             ||.|::|.|.:|..:.:...||..|::|..|                          ...|..|
Human   196 -LVNLDRLLLHENQLQWVHHKAFHDLRRLTTL--------------------------FLFNNSL 233

  Fly   338 LEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVM----WLHNLLV 398
            .|:|                       .|.|.|...|:.|.|:.||..|.||..    ||...  
Human   234 SELQ-----------------------GECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRF-- 273

  Fly   399 AKNASQDDVSELLCEFPERLRGESLRHLNPA-MMGCTHADPRKQALIGALLVGSAATITALALVL 462
                 :...|.:.|..|....|:.|:.|... ...||               |.|:.        
Human   274 -----RGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCT---------------GPASP-------- 310

  Fly   463 YRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPG 527
                |:|:                    ..|....|..:|.:||               :||.|.
Human   311 ----HQIK--------------------SHTLTTTDRAARKEHH---------------SPHGPT 336

  Fly   528 AT--HHYG----------MCPMP-----VNDLG-----------AIDPQQKFQQLVVPTA 559
            .:  |.:|          .|..|     ::..|           |.|.|.||...::|||
Human   337 RSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTA 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 2/17 (12%)
LRR_8 83..142 CDD:290566 9/58 (16%)
leucine-rich repeat 84..107 CDD:275380 0/22 (0%)
leucine-rich repeat 108..131 CDD:275380 6/22 (27%)
LRR_RI 129..421 CDD:238064 75/296 (25%)
LRR_8 132..190 CDD:290566 22/58 (38%)
leucine-rich repeat 132..155 CDD:275380 6/22 (27%)
leucine-rich repeat 156..179 CDD:275380 12/23 (52%)
leucine-rich repeat 180..204 CDD:275380 8/23 (35%)
LRR_8 203..263 CDD:290566 17/59 (29%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 7/22 (32%)
LRR_8 252..308 CDD:290566 11/55 (20%)
leucine-rich repeat 253..276 CDD:275380 1/22 (5%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
leucine-rich repeat 301..322 CDD:275380 2/20 (10%)
LRR_8 325..384 CDD:290566 11/58 (19%)
leucine-rich repeat 326..350 CDD:275380 4/23 (17%)
leucine-rich repeat 351..373 CDD:275380 3/21 (14%)
RTN4RL1NP_848663.1 leucine-rich repeat 37..54 CDD:275380 3/31 (10%)
LRR 1 55..76 8/54 (15%)
LRR_8 57..111 CDD:316378 18/55 (33%)
leucine-rich repeat 57..77 CDD:275380 6/21 (29%)
LRR 2 77..98 7/20 (35%)
leucine-rich repeat 78..101 CDD:275380 6/22 (27%)
LRR 3 101..123 10/21 (48%)
leucine-rich repeat 102..126 CDD:275380 12/23 (52%)
LRR_8 126..185 CDD:316378 22/59 (37%)
LRR 4 126..147 8/21 (38%)
leucine-rich repeat 127..150 CDD:275380 8/23 (35%)
LRR 5 150..171 8/20 (40%)
leucine-rich repeat 151..174 CDD:275380 9/22 (41%)
LRR_8 174..233 CDD:316378 19/108 (18%)
LRR 6 174..195 6/20 (30%)
leucine-rich repeat 175..198 CDD:275380 8/46 (17%)
LRR 7 198..219 6/20 (30%)
leucine-rich repeat 199..222 CDD:275380 7/22 (32%)
LRR 8 222..243 8/69 (12%)
leucine-rich repeat 223..246 CDD:275380 9/71 (13%)
TPKR_C2 255..300 CDD:326558 13/51 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..382 19/139 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..417 124/580 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11786
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
44.010

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