DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Rxfp2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_011239323.1	Gene:	Rxfp2 / 140498	MGIID:	2153463	Length:	740	Species:	Mus musculus

Alignment Length:	462	Identity:	111/462 - (24%)
Similarity:	195/462 - (42%)	Gaps:	84/462 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQFYAELTFLDLSS 91
            |:..|..|.|.:|.|  :|.:..|..:|          .:.||              :|.|.|..
Mouse    94 LSQYPQHCYCRENEL--ECVKADLKAVP----------KVSSN--------------VTLLSLKK 132

  Fly    92 NHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKI 156
            |.:..:|.:.|:...:|::::|.||.|..||.:.|:||..:.:|.|..|.|:.|..|.|..|.::
Mouse   133 NKIHRLPVKVFSRYTELRKIYLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQL 197

  Fly   157 EELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGMNTLQSIQAD 221
            ..|.|.:|.|..:..|:|.||:.|..|.:..|.|..:|:.:..| ||.|..:.|..|.::.|...
Mouse   198 AWLILDDNPITRISQKSFMGLNSLFFLSMVGNRLEALPETLCAQ-MPQLNWVDLANNGIKYITNS 261

  Fly   222 AFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQND 286
            .|.....||.|.|....:..:...:|..|:.|..||||.|.:.::|....|.|..|::|:|..|.
Mouse   262 TFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNMITKLPVHLFSDLHLLQKLNLSSNP 326

  Fly   287 FEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKML-----LEVQEGALS 346
            ...:.:..|..||||:.|::. .:.:..:.||.|....||.::.|.:.:..     :.:...:..
Mouse   327 LLYVHKNQFGSLKQLQSLDLE-RIEIPNISTGMFQPMKNLSHIYLKTFRYCSYVPHVRICMPSTD 390

  Fly   347 GLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSC--DCRVMWLHNLLVAKNASQDDVSE 409
            |:|..:.  |.||.:..::..:..:            ::|  :..|:.:.:|:.|:|.:.....:
Mouse   391 GISSSED--LLANGILRVSVWVIAF------------ITCVGNFLVIAVRSLIKAENTTHAMSIK 441

  Fly   410 LLC--------------EFPERLRGESLRHLNPAMMGCTHADPRKQAL-----IGALLVGSAATI 455
            :||              .|..:.||:.                :|.||     :...|:|..||:
Mouse   442 ILCCADCLMGVYLFSVGVFDIKYRGQY----------------QKYALLWMESVPCRLLGFLATL 490

  Fly   456 TALALVL 462
            :....||
Mouse   491 STEVSVL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	19/58 (33%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	10/22 (45%)
		LRR_RI	129..421	CDD:238064	75/312 (24%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..308	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	8/63 (13%)
		leucine-rich repeat	326..350	CDD:275380	3/28 (11%)
		leucine-rich repeat	351..373	CDD:275380	3/21 (14%)
Rxfp2	XP_011239323.1	LDLa	31..66	CDD:238060
		LRR	104..353	CDD:227223	77/276 (28%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	148..207	CDD:338972	21/58 (36%)
		leucine-rich repeat	149..172	CDD:275380	10/22 (45%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		leucine-rich repeat	221..244	CDD:275380	7/23 (30%)
		leucine-rich repeat	245..268	CDD:275380	5/22 (23%)
		leucine-rich repeat	269..292	CDD:275380	6/22 (27%)
		leucine-rich repeat	293..316	CDD:275380	9/22 (41%)
		leucine-rich repeat	317..340	CDD:275380	6/22 (27%)
		leucine-rich repeat	341..360	CDD:275380	4/19 (21%)
		7tm_GPCRs	403..688	CDD:391938	19/123 (15%)
		TM helix 1	403..429	CDD:341315	2/37 (5%)
		TM helix 2	436..461	CDD:341315	2/24 (8%)
		TM helix 3	481..511	CDD:341315	6/17 (35%)
		TM helix 4	522..544	CDD:341315
		TM helix 5	572..601	CDD:341315
		TM helix 6	617..647	CDD:341315
		TM helix 7	656..681	CDD:341315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000