DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trn and LRRC15

DIOPT Version :9

Sequence 1:NP_001261796.1 Gene:trn / 39491 FlyBaseID:FBgn0010452 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001128529.2 Gene:LRRC15 / 131578 HGNCID:20818 Length:587 Species:Homo sapiens


Alignment Length:473 Identity:128/473 - (27%)
Similarity:208/473 - (43%) Gaps:71/473 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ILASIGVEP-AAGLA--NCPPGCQCDDNTLVVQCGEGQLDVLPIAL------------------- 57
            :|..:|.:. .||||  .||..|.| .....|:|...::..:|..|                   
Human    13 LLLLVGCQAWGAGLAYHGCPSECTC-SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNE 76

  Fly    58 NP--SIQRLV---IKSNKIKTI-DSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHN 116
            :|  :|..|:   |:.|::..| ..:.:....|.:|.|::|.|..:|...|.....|:.:.|:.|
Human    77 SPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSN 141

  Fly   117 KIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLR 181
            ::.||....|...|.:..|.|.||.:..:..|.|..|:.:.:||||:|.:.::.|:.|..|..|:
Human   142 QLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQ 206

  Fly   182 ILYLDDNALTTVP-----------------------DPVIFQAMPSLAELFLGMNTLQSIQADAF 223
            :|.|.:|.||.:|                       .|.:|....:|..|:|..|.:..:....|
Human   207 VLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVF 271

  Fly   224 QDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFE 288
            ..|..|.||.|.|.||:.:|...|..:..||.|.|.||.:..:|....|.|.:|:.|.|.:|...
Human   272 MQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQIS 336

  Fly   289 VISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSD-NG-------NLEYLNLSSNKMLLEVQEGAL 345
            .||.|||.||.:|:.|.::         |.|..| :|       ||:.::|.:|: |.::.....
Human   337 FISPGAFNGLTELRELSLH---------TNALQDLDGNVFRMLANLQNISLQNNR-LRQLPGNIF 391

  Fly   346 SGLSQLKHVVLKANALTSLAEGLFP-WKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSE 409
            :.::.|..:.|:.|.|.:|..|:|. ...|..|.|.:||..||..::.|.|.|:.........:.
Human   392 ANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTV 456

  Fly   410 LLCEFPERLRGESLRHLN 427
            .:|..|..:||:||..:|
Human   457 PVCFSPANVRGQSLIIIN 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trnNP_001261796.1 leucine-rich repeat 62..80 CDD:275380 4/21 (19%)
LRR_8 83..142 CDD:290566 18/58 (31%)
leucine-rich repeat 84..107 CDD:275380 7/22 (32%)
leucine-rich repeat 108..131 CDD:275380 6/22 (27%)
LRR_RI 129..421 CDD:238064 91/323 (28%)
LRR_8 132..190 CDD:290566 19/57 (33%)
leucine-rich repeat 132..155 CDD:275380 7/22 (32%)
leucine-rich repeat 156..179 CDD:275380 8/22 (36%)
leucine-rich repeat 180..204 CDD:275380 9/46 (20%)
LRR_8 203..263 CDD:290566 21/59 (36%)
leucine-rich repeat 205..228 CDD:275380 6/22 (27%)
leucine-rich repeat 229..252 CDD:275380 9/22 (41%)
LRR_8 252..308 CDD:290566 22/55 (40%)
leucine-rich repeat 253..276 CDD:275380 9/22 (41%)
leucine-rich repeat 277..300 CDD:275380 11/22 (50%)
leucine-rich repeat 301..322 CDD:275380 4/20 (20%)
LRR_8 325..384 CDD:290566 16/59 (27%)
leucine-rich repeat 326..350 CDD:275380 4/23 (17%)
leucine-rich repeat 351..373 CDD:275380 7/22 (32%)
LRRC15NP_001128529.2 LRR_8 60..119 CDD:290566 10/58 (17%)
LRR_RI 63..309 CDD:238064 63/245 (26%)
LRR_8 88..167 CDD:290566 21/78 (27%)
leucine-rich repeat 88..108 CDD:275380 3/19 (16%)
leucine-rich repeat 109..156 CDD:275380 13/46 (28%)
leucine-rich repeat 157..180 CDD:275380 7/22 (32%)
LRR_8 180..239 CDD:290566 15/58 (26%)
leucine-rich repeat 181..204 CDD:275380 8/22 (36%)
leucine-rich repeat 205..228 CDD:275380 7/22 (32%)
LRR_8 228..287 CDD:290566 13/58 (22%)
leucine-rich repeat 229..252 CDD:275380 2/22 (9%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 9/22 (41%)
LRR_8 299..359 CDD:290566 23/68 (34%)
LRR_4 299..340 CDD:289563 14/40 (35%)
leucine-rich repeat 301..324 CDD:275380 9/22 (41%)
LRR_4 324..364 CDD:289563 16/48 (33%)
leucine-rich repeat 325..348 CDD:275380 11/22 (50%)
leucine-rich repeat 349..370 CDD:275380 6/29 (21%)
LRR_8 372..430 CDD:290566 15/58 (26%)
leucine-rich repeat 373..393 CDD:275380 4/20 (20%)
leucine-rich repeat 397..418 CDD:275380 7/20 (35%)
TPKR_C2 429..>468 CDD:301599 10/38 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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