DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and Chad

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_031715.1	Gene:	Chad / 12643	MGIID:	1096866	Length:	358	Species:	Mus musculus

Alignment Length:	443	Identity:	119/443 - (26%)
Similarity:	187/443 - (42%)	Gaps:	92/443 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQRNMMIAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLV 65
            |.|.::.:.|.:..:|      ||  ||.||..|.|..:...|.|.:..|..:| .::.:.:.|.
Mouse     1 MARALLFSLVFLAILL------PA--LAACPQNCHCHGDLQHVICDKVGLQKIP-KVSETTKLLN 56

  Fly    66 IKSNKIKTI-DSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGL 129
            ::.|....: .:|.:....|..|.|...::..:....|...|:|..::|:||.|..:....|..|
Mouse    57 LQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDL 121

  Fly   130 SAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVP 194
            :.:|.|.|..|::|||.:|..:||:.:..|.|..|:|..|...||.|...||.|||.:|||:
Mouse   122 TELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALS--- 183

  Fly   195 DPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLS 259
                                  |:|..:..|::.|.:..                        |.
Mouse   184 ----------------------SLQPGSLDDVENLAKFH------------------------LD 202

  Fly   260 DNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNG 324
            .|:|...||..||||..:|:|.|..|..:.|.:.||..              ..|.:...:.||.
Mouse   203 KNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQS--------------FGRYLETLWLDNT 253

  Fly   325 NLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCR 389
            |||           :..:.|.||::.||||.|..|.|..|... ||:.:|:||.|:.||..|.|:
Mouse   254 NLE-----------KFSDAAFSGVTTLKHVHLDNNRLNQLPSS-FPFDNLETLTLTNNPWKCTCQ 306

  Fly   390 VMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQA 442
            :..|...|.|| ||:.|.:   |..|.:.:|:.:|..: |:..|  ..|.|::
Mouse   307 LRGLRRWLEAK-ASRPDAT---CSSPAKFKGQRIRDTD-ALRSC--KSPTKRS 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	3/18 (17%)
		LRR_8	83..142	CDD:290566	16/58 (28%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	83/291 (29%)
		LRR_8	132..190	CDD:290566	24/57 (42%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	6/59 (10%)
		leucine-rich repeat	205..228	CDD:275380	3/22 (14%)
		leucine-rich repeat	229..252	CDD:275380	1/22 (5%)
		LRR_8	252..308	CDD:290566	16/55 (29%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		leucine-rich repeat	301..322	CDD:275380	1/20 (5%)
		LRR_8	325..384	CDD:290566	21/58 (36%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	10/21 (48%)
Chad	NP_031715.1	LRRNT	22..48	CDD:279764	8/26 (31%)
		LRR 1	51..72		3/20 (15%)
		leucine-rich repeat	52..75	CDD:275380	3/22 (14%)
		LRR_8	74..134	CDD:290566	16/59 (27%)
		LRR 2	75..96		4/20 (20%)
		leucine-rich repeat	76..99	CDD:275380	4/22 (18%)
		LRR_RI	<89..281	CDD:238064	71/265 (27%)
		LRR 3	99..120		6/20 (30%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR 4	123..144		8/20 (40%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_8	147..206	CDD:290566	22/107 (21%)
		LRR 5	147..168		7/20 (35%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR 6	171..192		10/45 (22%)
		leucine-rich repeat	172..195	CDD:275380	11/47 (23%)
		LRR 7	195..216		7/44 (16%)
		leucine-rich repeat	196..219	CDD:275380	10/46 (22%)
		LRR 8	219..240		7/20 (35%)
		LRR_8	220..279	CDD:290566	22/83 (27%)
		leucine-rich repeat	220..243	CDD:275380	7/36 (19%)
		LRR 9	244..265		6/31 (19%)
		leucine-rich repeat	245..268	CDD:275380	8/33 (24%)
		LRR 10	268..289		10/21 (48%)
		leucine-rich repeat	269..291	CDD:275380	10/22 (45%)
		LRRCT	299..346	CDD:214507	17/53 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..358		9/37 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010