Protein Alignment trn and VASN

DIOPT Version :10

• Sequence 1: NP_001261796.1
• Gene: trn / 39491
• FlyBaseID: FBgn0010452
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_612449.2
• Gene: VASN / 114990
• HGNCID: 18517
• Length: 673
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 114/423 - (26%)
• Similarity: 172/423 - (40%)
• Gaps: 90/423 - (21%)

  Fly    15 ILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDS-SI 78
            :|.::|    .|:..||.||||.....|. |...|...:|..:.|....|.:..|.|..:|: |.
Human    13 LLLALG----PGVQGCPSGCQCSQPQTVF-CTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSF 72

  Fly    79 QFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQIS 143
            .....|..||||.|.:.::|...|.....|..:.|..|::.:|:|:||.||.
Human    73 AGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLR------------- 124

  Fly   144 ELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAEL 208
                       ::|.|.||:|||.::.|.|||.|.:|..|.|.||.|..:| |:   .:|.|..|
Human   125 -----------RLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALP-PL---RLPRLLLL 174

  Fly   209 FLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSK 273
            .|..|:|.::: ....|...:..|.|.|..|:.:....|..|:.|..||:|||:|:|:|.|
Human   175 DLSHNSLLALE-PGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPV---- 234

  Fly   274 LVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLL 338
                                 ..||:.|.|                         |.|:.|..:.
Human   235 ---------------------IRGLRGLTR-------------------------LRLAGNTRIA 253

  Fly   339 EVQEGALSGLSQLKHV---VLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAK 400
            :::...|:||:.|:.:   .|...||.....||||  .|:.|..:.||.:|.|.:.|....:...
Human   254 QLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFP--RLRLLAAARNPFNCVCPLSWFGPWVRES 316

  Fly   401 NASQDDVSELLCEFPERLRGESLRHLNPAMMGC 433
            :.:.....|..|.||.:..|..|..|:.|..||
Human   317 HVTLASPEETRCHFPPKNAGRLLLELDYADFGC 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	5/18 (28%)
		LRR	82..406	CDD:443914	85/326 (26%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		leucine-rich repeat	156..179	CDD:275380	12/22 (55%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	2/22 (9%)
		leucine-rich repeat	301..322	CDD:275380	2/20 (10%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	8/24 (33%)
		LRRCT	382..434	CDD:214507	15/52 (29%)
VASN	NP_612449.2	LRRNT	23..54	CDD:214470	11/31 (35%)
		leucine-rich repeat	34..56	CDD:275380	5/22 (23%)
		LRR 1	52..74		6/21 (29%)
		leucine-rich repeat	57..77	CDD:275380	5/19 (26%)
		LRR	<72..>295	CDD:443914	80/303 (26%)
		LRR 2	77..98		8/20 (40%)
		leucine-rich repeat	78..101	CDD:275380	8/22 (36%)
		LRR 3	101..122		7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	9/46 (20%)
		LRR 4	125..146		10/20 (50%)
		leucine-rich repeat	126..149	CDD:275380	12/22 (55%)
		LRR 5	149..170		8/24 (33%)
		leucine-rich repeat	150..193	CDD:275380	15/47 (32%)
		LRR 6	171..191		5/20 (25%)
		LRR 7	193..214		5/20 (25%)
		leucine-rich repeat	194..217	CDD:275380	6/22 (27%)
		LRR 8	217..238		10/45 (22%)
		leucine-rich repeat	218..240	CDD:275380	12/46 (26%)
		LRR 9	240..262		6/46 (13%)
		leucine-rich repeat	241..265	CDD:275380	8/48 (17%)
		LRR 10	265..287		5/21 (24%)
		leucine-rich repeat	266..286	CDD:275380	4/19 (21%)
		PCC	270..>349	CDD:188093	22/80 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	358..404
		EGF	409..440	CDD:394967
		fn3	466..535	CDD:394996