DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and ELFN2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_443138.2	Gene:	ELFN2 / 114794	HGNCID:	29396	Length:	820	Species:	Homo sapiens

Alignment Length:	865	Identity:	182/865 - (21%)
Similarity:	278/865 - (32%)	Gaps:	256/865 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IGVEPAAGLANCPPGCQCDDNTLV---------VQCGEGQ--LDVLPIALNPSIQRLVIKSNKIK 72
            :|:..||.|..|.||....|..|:         ..|.:.|  .:.:|..:|.::..|.:..||:|
Human     4 LGLCAAALLCVCRPGAVRADCWLIEGDKGYVWLAICSQNQPPYETIPQHINSTVHDLRLNENKLK 68

  Fly    73 TIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNL 137
            .:     .|:.|                               |:.|.:           |.|||
Human    69 AV-----LYSSL-------------------------------NRFGNL-----------TDLNL 86

  Fly   138 RGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAM 202
            ..|:||.:..|.|.....::.|.||.|::..|......|:|:|:.|::..| |..|..|..|...
Human    87 TKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHN-LIEVVTPTAFSEC 150

  Fly   203 PSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIP 267
            |||..:.|..|.|..:....|..|..|...||.|... |...|.|..|..|.:.:......||:.
Human   151 PSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPF-NCECDLFGFLAWLVVFNNVTKNYDRLQ 214

  Fly   268 SVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEV---NGALRLKRVM--TGAFSDNGNLE 327
            .....:..          .:.::....:..|..:..|:.   ||:|..:.|.  |...:|.....
Human   215 CESPREFA----------GYPLLVPRPYHSLNAITVLQAKCRNGSLPARPVSHPTPYSTDAQREP 269

  Fly   328 YLNLSSN-KMLLEVQEGALSGLS-------QLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPL 384
            ..|...| ..:|.|:..|.|...       :|.||...:..|..:..  .|:..:..|....|..
Human   270 DENSGFNPDEILSVEPPASSTTDASAGPAIKLHHVTFTSATLVVIIP--HPYSKMYILVQYNNSY 332

  Fly   385 SCDCRVMWLHNL--LVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGAL 447
            ..|  ||.|.|.  :|..:..:.......|....|    :.|..|...:..|..||     :...
Human   333 FSD--VMTLKNKKEIVTLDKLRAHTEYTFCVTSLR----NSRRFNHTCLTFTTRDP-----VPGD 386

  Fly   448 LVGSAATITALALVLYRCRHKIRETIKGGLWGN-SALG---------RKEREYQKTFCDEDYMSR 502
            |..|.:|.|          |.|. ||.|.|:|. ..||         |.:.|.||
Human   387 LAPSTSTTT----------HYIM-TILGCLFGMVIVLGAVYYCLRKRRMQEEKQK---------- 430

  Fly   503 HQHHPCSLGIHST-FPNTYTAPHHPGATHH----YGMCP-MPVNDLGAIDPQQKFQQLVVPTATM 561
                  |:.:..| ....|.|....|:..|    .|..| :||:.:.:| |....::|  |||..
Human   431 ------SVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVSRMASI-PSMIGEKL--PTAKG 486

  Fly   562 ISEKKLNNNKAL-------VSQGAIDD-----------------SASFVLHMKSATMGRDVHQQN 602
            : |..|:..|..       |..||..|                 ||:.:     :|:.::|.:.|
Human   487 L-EAGLDTPKVATKGNYIEVRTGAGGDGLARPEDDLPDLENGQGSAAEI-----STIAKEVDKVN 545

  Fly   603 PQLNH------YTKPQFLSATATVGD-----SCYSYADVPMVHGAPLGGPN--------QPQLRL 648
            ..:|:      .....||...::.||     .|.|.........|.  ||.        .|..:.
Human   546 QIINNCIDALKLDSASFLGGGSSSGDPELAFECQSLPAAAAASSAT--GPGALERPSFLSPPYKE 608

  Fly   649 TQEHFKQRELYD-----------QEMGS---------EILDH-----------NYIYSNTHYSMP 682
            :..|..||:|..           ...||         ::.||           .||...:..:.|
Human   609 SSHHPLQRQLSADAAVTRKTCSVSSSGSIKSAKVFSLDVPDHPAATGLAKGDSKYIEKGSPLNSP 673

  Fly   683 LEQLGRSKTPTPPPMPPA--------------LPLRNGLCATTGRRSF---QQKSASQKQQQNNN 730
            |::|         |:.||              |.::.....:..|.||   ..:..:....|..:
Human   674 LDRL---------PLVPAGSGGGSGGGGGIHHLEVKPAYHCSEHRHSFPALYYEEGADSLSQRVS 729

  Fly   731 TLRQFTHX--SSTYRRRQLS 748
            .|:..|..  .|||  .|||
Human   730 FLKPLTRSKRDSTY--SQLS 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/17 (24%)
		LRR_8	83..142	CDD:290566	8/58 (14%)
		leucine-rich repeat	84..107	CDD:275380	1/22 (5%)
		leucine-rich repeat	108..131	CDD:275380	2/22 (9%)
		LRR_RI	129..421	CDD:238064	71/306 (23%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	17/59 (29%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..308	CDD:290566	5/58 (9%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..300	CDD:275380	1/22 (5%)
		leucine-rich repeat	301..322	CDD:275380	6/25 (24%)
		LRR_8	325..384	CDD:290566	13/66 (20%)
		leucine-rich repeat	326..350	CDD:275380	6/31 (19%)
		leucine-rich repeat	351..373	CDD:275380	5/21 (24%)
ELFN2	NP_443138.2	LRR 1	56..77		6/56 (11%)
		leucine-rich repeat	60..80	CDD:275378	7/55 (13%)
		LRR_8	80..139	CDD:316378	19/70 (27%)
		LRR 2	80..101		9/31 (29%)
		leucine-rich repeat	81..104	CDD:275378	9/33 (27%)
		LRR 3	104..125		5/20 (25%)
		leucine-rich repeat	105..128	CDD:275378	6/22 (27%)
		LRR_8	127..187	CDD:316378	20/60 (33%)
		LRR 4	128..149		7/21 (33%)
		leucine-rich repeat	129..152	CDD:275378	7/23 (30%)
		LRR 5	152..173		6/20 (30%)
		leucine-rich repeat	153..166	CDD:275378	4/12 (33%)
		PCC	157..>227	CDD:188093	16/80 (20%)
		leucine-rich repeat	200..226	CDD:275380	3/35 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..294		10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..527		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	589..612		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..677		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100