DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_821072.1	Gene:	Lrrtm2 / 107065	MGIID:	2389174	Length:	515	Species:	Mus musculus

Alignment Length:	649	Identity:	151/649 - (23%)
Similarity:	228/649 - (35%)	Gaps:	220/649 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MMIAFVGIWCILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSN 69
            |:.|...:..:|..:   ||.|:| |||.|:|:  .|:..|.......:|.|
Mouse    13 MLAAIYAMSVVLKML---PALGMA-CPPKCRCE--KLLFYCDSQGFHSVPNA------------- 58

  Fly    70 KIKTIDSSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTV 134
               |...|:.       |.|..||:..:.:..||...:|..:||:||:|..:....|.||..:..
Mouse    59 ---TDKGSLG-------LSLRHNHITALERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKE 113

  Fly   135 LNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIF 199
            |.|..|:|..|...|||.|:.::.|:|..|::..|.|:.|.||.:|:.|:|..|:|.|:|
Mouse   114 LILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIP----- 173

  Fly   200 QAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLD 264
                                ...|.|.:.|..|:|....||:::.:.|.||.:||.|.|..|:|.
Mouse   174 --------------------VRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLT 218

  Fly   265 RIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYL 329
            :|......:|..|..|.|..|....::.|.......|::|::.|. .:|.:....|....||:.|
Mouse   219 KINFAHFLRLSSLHTLFLQWNKISNLTCGMDWTWSTLEKLDLTGN-EIKAIDLTVFETMPNLKIL 282

  Fly   330 NLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRV---- 390
            .:.:||            |:.|...:|  |:|          |.|.|:.||.|...|..||
Mouse   283 LMDNNK------------LNSLDSKIL--NSL----------KSLTTVGLSGNLWECSPRVCALA 323

  Fly   391 --------MWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGAL 447
                    .|.|:              :||..|:..:||.:.........|.:.
Mouse   324 SWLGSFQGRWEHS--------------ILCHSPDHTQGEDILDAVHGFQLCWNL----------- 363

  Fly   448 LVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQKTFCDEDYMSRHQHH------ 506
                :.|:||:| ..||                    ....||.|       :|...:|
Mouse   364 ----STTVTAMA-TTYR--------------------DPTTEYTK-------ISSSSYHVGDKEI 396

  Fly   507 PCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQLVVPTATM---------- 561
            |.:.||..|            ...|:   |.|.|.:        |.|.|: |.||
Mouse   397 PTTAGIAVT------------TEEHF---PEPDNAI--------FTQRVI-TGTMALLFSFFFII 437

  Fly   562 ----ISEK-------------KLNNNKALVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHY 608
                ||.|             .:.|::.|.||..        |||.      ::..|.| .|.|
Mouse   438 FIVFISRKCCPPTLRRIRQCSMIQNHRQLRSQTR--------LHMS------NMSDQGP-YNEY 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	18/58 (31%)
		leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		LRR_RI	129..421	CDD:238064	77/303 (25%)
		LRR_8	132..190	CDD:290566	21/57 (37%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	15/59 (25%)
		leucine-rich repeat	205..228	CDD:275380	2/22 (9%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..308	CDD:290566	15/55 (27%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	16/58 (28%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	4/21 (19%)
Lrrtm2	NP_821072.1	LRR 1	63..83		6/26 (23%)
		LRR	<65..312	CDD:227223	82/303 (27%)
		leucine-rich repeat	66..86	CDD:275380	6/19 (32%)
		LRR 2	86..107		7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		LRR 3	110..131		7/20 (35%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		LRR 4	134..155		6/20 (30%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	158..179		8/45 (18%)
		leucine-rich repeat	159..182	CDD:275380	9/47 (19%)
		LRR 6	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		LRR 7	206..227		7/20 (35%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		LRR 8	230..251		5/20 (25%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR 9	254..275		5/21 (24%)
		leucine-rich repeat	255..278	CDD:275380	5/23 (22%)
		LRR 10	278..299		8/34 (24%)
		leucine-rich repeat	279..300	CDD:275380	8/34 (24%)
		PCC	284..>351	CDD:188093	23/104 (22%)
		Involved in DLG4-binding. /evidence=ECO:0000250	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910