DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and LRRC53

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001369209.1	Gene:	LRRC53 / 105378803	HGNCID:	25255	Length:	1247	Species:	Homo sapiens

Alignment Length:	674	Identity:	146/674 - (21%)
Similarity:	246/674 - (36%)	Gaps:	149/674 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 TFIGLSAVT--VLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDD 187
            |:|..:.:|  ||.:....:|.:.....:.|..:..|:|..|.|..:...|..||:.||.|.|:.
Human    26 TYIVAAPMTTRVLIITDGYLSSIESTNLSLLFNLALLSLSRNGIEDVQEDALHGLTMLRTLLLEH 90

  Fly   188 NAL--TTVPDPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLG- 249
            |.:  :::.|.. |..:.||..|.|..|.|::::...|::..|||||:|.|..:.|::..||.|
Human    91 NQISSSSLTDHT-FSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNLTDSSFGGT 154

  Fly   250 -LQELRILDLSDNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNG----- 308
             |..||.||||:|.:..|.......|.:|:::.|.:|....:.: .|..||||..|.::.
Human   155 NLHSLRYLDLSNNFISYIGKDAFRPLPQLQEVDLSRNRLAHMPD-VFTPLKQLILLSLDKNQWSC 218

  Fly   309 -------ALRLKRVMTGAFSDNGNLEYLN-------LSSNKMLLEVQEGALSGLSQLKHVVLKAN 359
                   |..|:..:..:.....|.:.||       :::.:.:|.:.|......:....:|||..
Human   219 TCDLHPLARFLRNYIKSSAHTLRNAKDLNCQPSTAAVAAAQSVLRLSETNCDSKAPNFTLVLKDR 283

  Fly   360 ALTSLAEGLFPWKDLQTLDL--SENPLSCDCRVMWLHNLLVAKNASQDDVSELLC--EFPERLRG 420
            :      .|.|..|:..|.:  ....:...|..:.:.|..:.:..:.:..||.||  .|.|.|..
Human   284 S------PLLPGPDVALLTVLGFAGAVGLTCLGLVVFNWKLHQGKANEHTSENLCCRTFDEPLCA 342

  Fly   421 ESLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGR 485
            ...|:.:.......|.....:..:.: .|||...:..|....::...........|.:.|  |.:
Human   343 HEARNYHTKGYCNCHLTQENEIKVMS-TVGSRKEMPLLQENSHQATSASESATLDGSFRN--LKK 404

  Fly   486 KEREYQKT-FCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDP-- 547
            |:|....| ||.:   .|..|..|     |..|....|.:..|....|.  |..|..|..::|
Human   405 KDRGVGSTLFCQD---GRLLHSEC-----SEPPGNMRAFNEAGLLTTYN--PRKVQKLWNLEPGE 459

  Fly   548 --QQKFQQLVVPTATMISEKKLNNNKALVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTK 610
              .|..|..::.|                     :|.:|.:...:.||
Human   460 VQPQTLQHHIIRT---------------------EDISSDIFRRRYAT----------------- 486

  Fly   611 PQFLSATATVGDSCYSYADVPMVHGAPLGGPNQPQLRLTQEHFKQRELYDQEMGSEILDH---NY 672
                .|:|..|:|.                    :.|||.|.: |..:..::.|  :..|   ::
Human   487 ----PASALAGESL--------------------EKRLTNESW-QPPIEKEDNG--LHPHRQRHF 524

  Fly   673 IYSNT--------HYSMPLEQLGRSKTPTP-----PPMPPALPLRNGL-CATTGRRSFQ------ 717
            |.|::        ||...:.|..|||...|     ...|......|.| |.......|:
Human   525 ITSSSSKPCEPEEHYVQKIVQKNRSKYDDPCGLLKQSKPRYFQPNNSLICKYVPCEQFEDYMKEK 589

  Fly   718 -----QKSASQKQQ-QNNNTLRQF 735
                 |.|..:|:| |.|:.:.:|
Human   590 KPNRRQHSKPEKEQIQINSAIEKF 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380
		LRR_8	83..142	CDD:290566	5/18 (28%)
		leucine-rich repeat	84..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380	2/5 (40%)
		LRR_RI	129..421	CDD:238064	79/320 (25%)
		LRR_8	132..190	CDD:290566	17/59 (29%)
		leucine-rich repeat	132..155	CDD:275380	5/24 (21%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	7/25 (28%)
		LRR_8	203..263	CDD:290566	26/61 (43%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	11/24 (46%)
		LRR_8	252..308	CDD:290566	18/55 (33%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	4/32 (13%)
		LRR_8	325..384	CDD:290566	12/67 (18%)
		leucine-rich repeat	326..350	CDD:275380	4/30 (13%)
		leucine-rich repeat	351..373	CDD:275380	5/21 (24%)
LRRC53	NP_001369209.1	LRR 1	34..55		4/20 (20%)
		LRR 2	58..79		5/20 (25%)
		LRR 3	82..102		6/19 (32%)
		LRR_8	83..143	CDD:404697	21/60 (35%)
		leucine-rich repeat	83..108	CDD:275380	7/25 (28%)
		LRR 4	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		LRR_8	131..193	CDD:404697	24/61 (39%)
		LRR 5	132..153		10/20 (50%)
		leucine-rich repeat	133..158	CDD:275380	11/24 (46%)
		LRR 6	158..179		8/20 (40%)
		leucine-rich repeat	159..182	CDD:275380	9/22 (41%)
		LRR 7	182..203		4/21 (19%)
		leucine-rich repeat	183..205	CDD:275380	5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	828..866
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1247
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930