Protein Alignment trn and LRRN2

DIOPT Version :10

• Sequence 1: NP_001261796.1
• Gene: trn / 39491
• FlyBaseID: FBgn0010452
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_006329.2
• Gene: LRRN2 / 10446
• HGNCID: 16914
• Length: 713
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 163/637 - (25%)
• Similarity: 254/637 - (39%)
• Gaps: 121/637 - (18%)

  Fly    13 WCILASIGVEPAAGLANCPPGCQCD-----------DNTLVVQCGEGQLDVLPIALNPSIQRLVI 66
            |...|:..|........|||.|.|.           .....|.|.:..|..:|.||....|.|::
Human    12 WVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLL 76

  Fly    67 KSNKIKTID-SSIQFYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLS 130
            :||.|..:| |.:.:.|.||.||||.|.........|....:|..:||..|::.::.:.:|.||:
Human    77 QSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLA 141

  Fly   131 AVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPD 195
            :                        ::||.|..|::..:.|:||.|||.|..|:|:.|.|..: |
Human   142 S------------------------LQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI-D 181

  Fly   196 PVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSD 260
            ...|:.:|:|..|.:|.|.:.:|....|:.|..|..|.|.|.:||.||..:..|||.|..|...|
Human   182 SRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYD 246

  Fly   261 NRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGN 325
            |:|.|:|...|.::..|:.|.|.:|..:.:..|.|..:..||.|.:|....|..:...|..:...
Human   247 NQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPE 311

  Fly   326 LEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSL----AEGLFPWKDLQTLDLSENPLSC 386
            |..|::::|..|..:...|...|.|::.::|..|||::|    .|.|   .:||.:.|..||:.|
Human   312 LTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESL---PNLQEVGLHGNPIRC 373

  Fly   387 DCRVMWLHNLLVAKNASQDDV-----SELLCEFPERLRGESLRHLNPAMMGCTHADP--RKQALI 444
            ||.:.|       .||:...|     ...||..|..|:...:|.: |......|..|  ..::..
Human   374 DCVIRW-------ANATGTRVRFIEPQSTLCAEPPDLQRLPVREV-PFREMTDHCLPLISPRSFP 430

  Fly   445 GALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKERE-YQKTFCDEDYMSRHQHHPC 508
            .:|.|.|..     ::||: ||               ||...|.| |..|             |.
Human   431 PSLQVASGE-----SMVLH-CR---------------ALAEPEPEIYWVT-------------PA 461

  Fly   509 SLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQK------FQQLVVPTATMISEKKL 567
            .|.:         .|.|.|  ..|.:.|....:|..:..::.      .|.||......:|   :
Human   462 GLRL---------TPAHAG--RRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVS---V 512

  Fly   568 NNNKALVSQGAIDDSASFVLHMKSATMGRDVHQQNPQLNHYTKPQFLSATAT 619
            ...:||:..|. |:.....|.:      ::.|..:..|:..|.|..:|...|
Human   513 VVGRALLQPGR-DEGQGLELRV------QETHPYHILLSWVTPPNTVSTNLT 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	7/18 (39%)
		LRR	82..406	CDD:443914	97/327 (30%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	0/22 (0%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	6/20 (30%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	7/25 (28%)
		LRRCT	382..434	CDD:214507	15/56 (27%)
LRRN2	NP_006329.2	leucine-rich repeat	337..360	CDD:275378	7/25 (28%)
		PCC	342..>420	CDD:188093	25/88 (28%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		Ig	422..514	CDD:472250	26/139 (19%)
		Ig strand B	441..445	CDD:409353	2/4 (50%)
		Ig strand C	454..458	CDD:409353	2/3 (67%)
		Ig strand E	480..484	CDD:409353	0/3 (0%)
		Ig strand F	494..499	CDD:409353	0/4 (0%)
		Ig strand G	507..510	CDD:409353	0/2 (0%)
		LRRNT	28..72	CDD:214470	11/43 (26%)
		leucine-rich repeat	51..69	CDD:275380	6/17 (35%)
		LRR 1	70..91		7/20 (35%)
		leucine-rich repeat	71..94	CDD:275380	7/22 (32%)
		LRR	<85..>324	CDD:443914	77/263 (29%)
		LRR 2	94..115		8/20 (40%)
		leucine-rich repeat	95..118	CDD:275380	8/22 (36%)
		LRR 3	118..139		5/20 (25%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		LRR 4	142..163		7/44 (16%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR 5	166..187		7/21 (33%)
		leucine-rich repeat	167..190	CDD:275380	7/23 (30%)
		LRR 6	190..211		6/20 (30%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		LRR 7	214..235		8/20 (40%)
		leucine-rich repeat	215..238	CDD:275380	10/22 (45%)
		LRR 8	238..259		8/20 (40%)
		leucine-rich repeat	239..262	CDD:275380	8/22 (36%)
		LRR 9	262..283		6/20 (30%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		LRR 10	286..305		5/18 (28%)
		leucine-rich repeat	287..311	CDD:275380	6/23 (26%)
		LRR_8	310..371	CDD:404697	18/63 (29%)
		LRR 11	311..333		5/21 (24%)
		leucine-rich repeat	312..334	CDD:275380	5/21 (24%)
		LRR 12	336..357		6/20 (30%)