DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and cd180

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001297419.1	Gene:	cd180 / 101885327	ZFINID:	ZDB-GENE-070705-323	Length:	665	Species:	Danio rerio

Alignment Length:	515	Identity:	119/515 - (23%)
Similarity:	191/515 - (37%)	Gaps:	140/515 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTI-DSSIQFYAELTFLDLSSNHLMTIPQ 99
            |...|....|.:..|..:|..:..|:|.|....|.:..: :|:.|....|..||::...:..|.:
Zfish    32 CQQITKGYDCNDMDLQSIPDEIPNSVQILQFSFNYLPALYNSTFQRLKSLRSLDVTRCSITFIYE 96

  Fly   100 RTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGEN 164
            ..|.||..|:.:.|..|.:..|::..|.|..|:..|:|..::|.:|.......|..:|.|:|..:
Zfish    97 DVFTYQPHLEVLLLTGNPLVFIASTAFSGPLALKYLSLVQSKIKQLSDIPSENLAYLEVLDLRGS 161

  Fly   165 RIGYLDPKAFDGLS-----QLRILYLDDNALTTVPDPVIFQAMPSLAEL------FLGMNTLQSI 218
            .|     ::.:|||     .|:.|.||.|.:    |.:.|..:...:.|      |.| |....|
Zfish   162 NI-----RSLNGLSNFRWQNLKSLQLDLNFI----DRISFNDLQPFSNLAGVSISFKG-NDFIYI 216

  Fly   219 QADAFQD--------------------LKGL-----TRLEL-----------KGASLR------- 240
            :..||..                    ||||     .||.|           ..|:|:
Zfish   217 EPGAFHSLNLSSLDFSGCLNKMNISSLLKGLEGIKTNRLNLGLYETDSNVYIASAALQSFCNIFV 281

  Fly   241 -----------NISHDSFLGLQELRILDLSDNRLDRIP--SVGLSKLVRLEQLSLGQNDFEVISE 292
                       ::::.:|..|:.|:.|||:...|:.:|  :.|||   .|..|.|.:|.|:.:.:
Zfish   282 SDLDFQLQHFLDLNNSTFHCLEGLKKLDLTRAHLNALPLNTTGLS---TLSHLILDENQFKDVCQ 343

  Fly   293 GAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLS----------SNKMLLEVQEGALSG 347
            ........|..|.::|.|:............|.||.|:||          .|..|..:.|..|..
Zfish   344 SNTRNFPMLTHLSISGNLKKLTFSNRCLDSLGLLEELDLSVSLVNPREPCCNNQLFGLGELKLLN 408

  Fly   348 LS----------------QLKHVVLKANALTSLAEGLFPWKDLQTL----------DLSENPLSC 386
            ||                :|:|:....:..|.|.:. .|:.:||:|          ||:...|..
Zfish   409 LSYGSPMFWSSKPFNVTPKLEHLDFSHSVYTLLNDS-SPFSNLQSLRTLNLSWSNTDLTNVHLFV 472

  Fly   387 DCRVMWLHNLLVAKNASQDDV---SEL----------------LCEFPERLRGESLRHLN 427
            ..:.  |.:|.:..||.|.:|   :||                :..|.|.| .:.|||||
Zfish   473 GLKA--LQHLNLRGNAIQGEVLTQTELFKCVPLLETLVLSACKITSFDENL-FKGLRHLN 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/18 (22%)
		LRR_8	83..142	CDD:290566	16/58 (28%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	90/413 (22%)
		LRR_8	132..190	CDD:290566	17/62 (27%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..179	CDD:275380	7/27 (26%)
		leucine-rich repeat	180..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	22/119 (18%)
		leucine-rich repeat	205..228	CDD:275380	8/48 (17%)
		leucine-rich repeat	229..252	CDD:275380	8/56 (14%)
		LRR_8	252..308	CDD:290566	16/57 (28%)
		leucine-rich repeat	253..276	CDD:275380	9/24 (38%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	4/20 (20%)
		LRR_8	325..384	CDD:290566	21/94 (22%)
		leucine-rich repeat	326..350	CDD:275380	11/49 (22%)
		leucine-rich repeat	351..373	CDD:275380	5/21 (24%)
cd180	NP_001297419.1	leucine-rich repeat	40..56	CDD:275380	3/15 (20%)
		LRR_8	56..115	CDD:316378	16/58 (28%)
		leucine-rich repeat	57..80	CDD:275380	5/22 (23%)
		leucine-rich repeat	81..104	CDD:275380	7/22 (32%)
		LRR_8	103..163	CDD:316378	15/59 (25%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		leucine-rich repeat	153..176	CDD:275380	7/27 (26%)
		leucine-rich repeat	177..200	CDD:275380	7/26 (27%)
		leucine-rich repeat	201..225	CDD:275380	7/24 (29%)
		leucine-rich repeat	226..247	CDD:275380	2/20 (10%)
		leucine-rich repeat	284..304	CDD:275378	2/19 (11%)
		leucine-rich repeat	305..327	CDD:275380	9/24 (38%)
		leucine-rich repeat	328..351	CDD:275380	5/22 (23%)
		leucine-rich repeat	352..376	CDD:275380	4/23 (17%)
		leucine-rich repeat	404..427	CDD:275380	3/22 (14%)
		LRR_8	426..487	CDD:316378	14/63 (22%)
		leucine-rich repeat	428..452	CDD:275380	6/24 (25%)
		leucine-rich repeat	453..476	CDD:275380	4/22 (18%)
		leucine-rich repeat	477..503	CDD:275380	8/25 (32%)
		LRR_8	502..561	CDD:316378	8/29 (28%)
		leucine-rich repeat	504..527	CDD:275380	4/23 (17%)
		leucine-rich repeat	528..549	CDD:275380	2/2 (100%)
		leucine-rich repeat	552..574	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100