DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and lingo3

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_004911049.2	Gene:	lingo3 / 100497438	XenbaseID:	XB-GENE-6051175	Length:	605	Species:	Xenopus tropicalis

Alignment Length:	407	Identity:	122/407 - (29%)
Similarity:	198/407 - (48%)	Gaps:	38/407 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLV-IKSNKIKTID-SSIQFYAELT 85
            |...:..||..|.|..|...|.|...:|..:|..: ||..||: :..|:|:.:: .....|:.|.
Frog    23 PEWKVLGCPARCDCTPNQRSVICHRKRLTTIPEGI-PSETRLLDLSKNRIRCLNPGDFSPYSLLE 86

  Fly    86 FLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTF 150
            .:|||.|.:.||....||....||.:.|..|::..|....|..||.:|:|::..|:|..|....|
Frog    87 EVDLSENIISTIEPGAFANLFFLQILKLKGNQLKLIPTGVFTKLSNLTLLDISENKIVILLDFMF 151

  Fly   151 TPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTV-PDPVIF-QAMPSLAELFLGMN 213
            ..|..::.|.:|:|.:.|:..|||.||..|..|.::...||:: |:.:.: |.:..|...:||:|
Frog   152 QDLRSLKSLEVGDNDLLYISQKAFYGLVSLDQLTIEKCNLTSISPESLSYLQGLEVLRLRYLGIN 216

  Fly   214 TLQSIQADAFQDLKGLTRLELKG-ASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKLVRL 277
               |::...||.|..|..|||:. ..|.::.:.:|.|| .|..|.::...|..:||..|..:|.|
Frog   217 ---SLEEQNFQKLYNLKELELESWPLLEDVCNTAFQGL-NLTSLSITYTNLTSVPSAALRNMVYL 277

  Fly   278 EQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLEVQE 342
            |.|:|..|...:|..|||..|.:|:.|.:.||. |..|.:.||.....:..||:|:| :|..::|
Frog   278 EYLNLSFNPIRIIQRGAFKDLVRLRELHIVGAF-LSTVESQAFLGLRQIRLLNVSNN-LLATLEE 340

  Fly   343 GALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDV 407
            .|...::                       .|:||.:.:|||:||||::|   :|..:.....|.
Frog   341 SAFQSVN-----------------------TLETLRVDDNPLACDCRLLW---ILQRRKTLNFDN 379

  Fly   408 SELLCEFPERLRGESLR 424
            .:.:|..|.:::|.:||
Frog   380 HQPVCASPAKIQGNALR 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	4/19 (21%)
		LRR_8	83..142	CDD:290566	20/58 (34%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	87/294 (30%)
		LRR_8	132..190	CDD:290566	18/57 (32%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	6/25 (24%)
		LRR_8	203..263	CDD:290566	18/60 (30%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	8/23 (35%)
		LRR_8	252..308	CDD:290566	19/55 (35%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		leucine-rich repeat	301..322	CDD:275380	8/20 (40%)
		LRR_8	325..384	CDD:290566	11/58 (19%)
		leucine-rich repeat	326..350	CDD:275380	7/23 (30%)
		leucine-rich repeat	351..373	CDD:275380	0/21 (0%)
lingo3	XP_004911049.2	LRR	41..359	CDD:227223	102/347 (29%)
		leucine-rich repeat	61..84	CDD:275380	5/22 (23%)
		leucine-rich repeat	85..108	CDD:275380	9/22 (41%)
		leucine-rich repeat	109..132	CDD:275380	7/22 (32%)
		leucine-rich repeat	133..156	CDD:275380	7/22 (32%)
		leucine-rich repeat	157..180	CDD:275380	9/22 (41%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		leucine-rich repeat	205..228	CDD:275380	8/25 (32%)
		leucine-rich repeat	229..252	CDD:275380	8/23 (35%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..298	CDD:275380	9/20 (45%)
		leucine-rich repeat	301..324	CDD:275380	8/23 (35%)
		leucine-rich repeat	325..345	CDD:275380	7/20 (35%)
		PCC	329..>399	CDD:188093	24/95 (25%)
		Ig	413..502	CDD:416386
		Ig strand A'	419..423	CDD:409353
		Ig strand B	429..438	CDD:409353
		Ig strand C	443..448	CDD:409353
		Ig strand C'	451..453	CDD:409353
		Ig strand D	462..465	CDD:409353
		Ig strand E	468..475	CDD:409353
		Ig strand F	481..489	CDD:409353
		Ig strand G	492..502	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6410
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940