DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and chadlb

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001274009.1	Gene:	chadlb / 100330176	ZFINID:	ZDB-GENE-121205-5	Length:	765	Species:	Danio rerio

Alignment Length:	729	Identity:	159/729 - (21%)
Similarity:	266/729 - (36%)	Gaps:	171/729 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILASIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDSSIQ 79
            ||.::.:..|.. |.||..|.||...|.:.|....|..:|    |:|..:.:|
Zfish    11 ILFALKIHTALS-AKCPKVCVCDSIQLTIACVNKNLTEVP----PTIDEITVK------------ 58

  Fly    80 FYAELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISE 144
                   |||..|.|..:|...||:...|..:.|.::.|.::....|..|..:.:|||..|:|..
Zfish    59 -------LDLRGNDLQELPTGAFAHTPYLTHLSLQNSNIRRVREGAFRKLGRLVLLNLANNKIEI 116

  Fly   145 LHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELF 209
            |:|.:|..|..:::|.:..||:..:.|.||..|..|.:|.|..|.|..:|: :.||.:.::..|.
Zfish   117 LYQESFDGLSSLKQLIIDRNRVEEIQPGAFSQLGFLNLLSLTHNQLVYIPN-MAFQGLQNIKWLR 180

  Fly   210 LGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLSDNRLDRIPSVGLSKL 274
            |..|.:..:..:||..|..||||.|....|:....::...|.|:..|:||.|.:..:....:| :
Zfish   181 LSHNFINYLATEAFAGLFTLTRLSLDNNELQFFPTETMTRLSEVTRLELSFNPMTYLGEESVS-M 244

  Fly   275 VRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSSNKMLLE 339
            ::|..|.|..|..:..|               |.|:.|          :..|.:|:||.|::.:
Zfish   245 LKLTHLLLDHNSLQDFS---------------NAAILL----------SPRLTHLDLSHNQLRI- 283

  Fly   340 VQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQ 404
                                 |..:|.|.   ..|..|:|:.||:.|.|.:..|......:....
Zfish   284 ---------------------LQPMAPGS---PKLTRLNLAGNPIYCSCYLRPLREWATRERVRL 324

  Fly   405 DDVSELLCEFPERLRGESLRHLNPAMMGCTHADPRKQALIGALLVGSAATITALALVLYRCRHKI 469
            ...    |..|..|.||:|..:.|..:.|...:...:|.:...::.:..|..:
Zfish   325 GGT----CGGPAHLSGENLEVVQPVNLRCLSQEAMLKAELEEQVLPALPTTPS------------ 373

  Fly   470 RETIKGGLWGNSALGRKEREYQKTFCDE-----------------DYMSRHQHH-PCSLGIHSTF 516
              ..||....|.|.   |.|.:.:.|:.                 |....|.|: |.     ::|
Zfish   374 --PKKGKCPANCAC---ETENRHSSCENKGHTKIPRGFSPDTRLLDLRGNHFHYIPA-----NSF 428

  Fly   517 PNTYTAPHHPGATHHYGMCP-------------------MPVNDLGAIDPQQKFQQLVVPTATMI 562
            |.|...     .:.|...|.                   :..|||.::.| :.|:.|  |..|.:
Zfish   429 PGTAEV-----VSLHLQRCKIHDIEDGAFSGMKSLVYLYLSENDLTSLTP-EAFKGL--PHLTYL 485

  Fly   563 SEKKLNNNKALVSQGAIDDSASFV-LHMKSATMGRDVHQQNPQLNHYTKPQ--FLSATATVGDSC 624
            ..:|  |......:||.......: |||::..:.:   .:...|....|.:  :|::.|....:.
Zfish   486 HLEK--NRFTQFPKGAFKLLPGLLALHMENNAIAK---LETGLLTSAEKLRGLYLTSNAITAAAP 545

  Fly   625 YSYADVPMVHGAPLGGPNQPQLRLTQEHFKQRELYDQEMGSEILDHNYI----------YSNTHY 679
            .::...|.:....||. |:.|...|:...|.|.|.:.:     |.||.|          ...|..
Zfish   546 QAFNPAPDLETLHLGS-NKLQEVPTEAFSKARSLAELK-----LSHNPIRWIGAGAFQPVGTTLR 604

  Fly   680 SMPLEQLGRSKTPT 693
            .:.|:.:|..|..|
Zfish   605 HLYLDHMGLEKVST 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	1/17 (6%)
		LRR_8	83..142	CDD:290566	17/58 (29%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_RI	129..421	CDD:238064	71/291 (24%)
		LRR_8	132..190	CDD:290566	20/57 (35%)
		leucine-rich repeat	132..155	CDD:275380	9/22 (41%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..308	CDD:290566	11/55 (20%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	3/20 (15%)
		LRR_8	325..384	CDD:290566	12/58 (21%)
		leucine-rich repeat	326..350	CDD:275380	5/23 (22%)
		leucine-rich repeat	351..373	CDD:275380	3/21 (14%)
chadlb	NP_001274009.1	leucine-rich repeat	58..79	CDD:275380	9/39 (23%)
		LRR_RI	59..307	CDD:238064	77/299 (26%)
		LRR_8	78..138	CDD:290566	16/59 (27%)
		leucine-rich repeat	80..103	CDD:275380	5/22 (23%)
		leucine-rich repeat	104..127	CDD:275380	9/22 (41%)
		LRR_8	126..184	CDD:290566	17/58 (29%)
		leucine-rich repeat	128..151	CDD:275380	7/22 (32%)
		leucine-rich repeat	152..175	CDD:275380	8/23 (35%)
		LRR_8	175..234	CDD:290566	18/58 (31%)
		leucine-rich repeat	176..199	CDD:275380	6/22 (27%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		leucine-rich repeat	224..246	CDD:275380	5/22 (23%)
		LRR_8	246..304	CDD:290566	20/107 (19%)
		leucine-rich repeat	247..270	CDD:275380	8/47 (17%)
		TPKR_C2	302..342	CDD:301599	11/43 (26%)
		LRR_RI	408..609	CDD:238064	42/224 (19%)
		leucine-rich repeat	410..433	CDD:275380	7/27 (26%)
		leucine-rich repeat	434..457	CDD:275380	2/27 (7%)
		LRR_8	436..492	CDD:290566	12/60 (20%)
		leucine-rich repeat	458..481	CDD:275380	6/25 (24%)
		LRR_8	480..540	CDD:290566	12/64 (19%)
		leucine-rich repeat	482..505	CDD:275380	5/24 (21%)
		leucine-rich repeat	506..529	CDD:275380	4/25 (16%)
		LRR_8	529..588	CDD:290566	15/64 (23%)
		leucine-rich repeat	530..553	CDD:275380	2/22 (9%)
		leucine-rich repeat	554..577	CDD:275380	6/23 (26%)
		leucine-rich repeat	578..602	CDD:275380	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010