DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and elfn1b

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_001920383.1	Gene:	elfn1b / 100144401	ZFINID:	ZDB-GENE-080327-21	Length:	814	Species:	Danio rerio

Alignment Length:	797	Identity:	156/797 - (19%)
Similarity:	257/797 - (32%)	Gaps:	263/797 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CGEGQ--LDVLPIALNPSIQRLVIKSNKIKTID-SSIQFYAELTFLDLSSNHLMTIPQRTFAYQK 106
            |.:.|  .:.:|:.:|.:|..|.:..|||::|. ||:..:..||:|:|:.|.:..|....|:.|.
Zfish    61 CSQNQPPYENIPMHINSTIVDLRLNENKIRSIHFSSLSRFGNLTYLNLTKNDISYIEDGAFSAQF 125

  Fly   107 KLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDP 171
            .||.:.:..||:..::.....||..:..|.|:.|.|..:....|.....||.::|..|||..||.
Zfish   126 NLQVLQIGFNKMRNLTEGMLRGLGRLQYLYLQANLIETVTANAFWECPAIENIDLSMNRIQQLDG 190

  Fly   172 KAFDGLSQLRILYLDDNA-------------LTTVPD----------PVIFQAMPSLAELFLGMN 213
            ..|.|||:|....|..|.             |...|:          |..|.....|::     |
Zfish   191 ATFRGLSKLTTCELYANPFSCSCELLGFLRWLVAFPNRTSERMACDTPAGFSGYSLLSQ-----N 250

  Fly   214 TLQSIQADAFQDLKGLTRLELKGASLRNIS---HDSFLGLQELRILDLSDNRLDRIPS------- 268
            .......:||..|..:...:       |::   |.|..|....|:.|||...||...|
Zfish   251 PRMPRYRNAFHALSSVCTDD-------NVTPYLHGSPDGGIPTRLPDLSPCGLDDCSSGTFPEET 308

  Fly   269 VGLS---------KLVRLEQ---------------------LSLGQNDF-----EVISEGAFMGL 298
            :.:|         .:::|::                     |.|..|.|     .:.|:...:.|
Zfish   309 ISISPTFLDSDARPIMKLKEVTHTSAVITIQIPNPFRKMYILVLYNNSFFTDIQNLKSQREEIEL 373

  Fly   299 KQLKR--------LEVNGALRLKR----VMTG-------AFSDNGNLEYL--------------- 329
            :.||.        ..:..:||...    :.||       ..:|:....|:
Zfish   374 QNLKSHTNYTYCVASIRNSLRFNHTCLTISTGPRTLQERVVNDSTATHYIMTILGCLFGMLIVLG 438

  Fly   330 -------------------------NLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLF 369
                                     ||...|...|:::|.:|.|||.:  :|.|.........|
Zfish   439 VVVHCLRKRKKQDEPKSKKLEKMKRNLIEMKYGTELEQGTISQLSQKQ--ILSAGETVQRMPYL- 500

  Fly   370 PWKDLQTLDLSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCT 434
                         |.:.|.....:..:......::.:..|:..|.|||    |:|.       |:
Zfish   501 -------------PAASDTDQYKMQEISGTPKTTKGNYMEVRSEQPER----SIRE-------CS 541

  Fly   435 HADPRKQALIGALLVGSAATITALA-------LVLYRCRHKIR------ETIKGGLWGNSALGRK 486
             ..|.:.:      .||.|.|:.:|       .::..|...::      :|.|.|....:
Zfish   542 -VPPSETS------QGSVAEISTIAKEVDKVNQIINNCIDALKSDSTSFQTAKSGAVSTA----- 594

  Fly   487 EREYQKTFCDEDYMSRHQHHPCSLGIHS-TFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQK 550
              |.|.....|       |.|...|..| .:...|   |||...||            ::|..||
Zfish   595 --EPQLVLISE-------HPPGKSGFLSPVYKGGY---HHPLQRHH------------SMDAPQK 635

  Fly   551 FQQLVVPTATMISEKKLNNNKALVSQGAI-------------DDSASFVLHMKSATMGRD---VH 599
                   .|:..|...|.:.::..|:||.             |:|....:...:|.:..:   :.
Zfish   636 -------RASTSSSGSLRSPRSFRSEGAYRSESKYIEKASPQDESGIITVTPAAAILRAEAERIR 693

  Fly   600 QQNPQLNHYTKPQFLSATATVGDSCYSYADVPMVHGAPLGGPNQPQLRLTQEHFKQRELYDQEMG 664
            |.:...:.|..|..:..:..|..|..|....|:....|                  |||...::.
Zfish   694 QYSEHRHSYPGPHHIEESIEVSGSRKSSILEPLTRSRP------------------RELSYSQLS 740

  Fly   665 SEILDHNYI-YSNTHYS 680
            .:.  ||.. ||:..||
Zfish   741 PQY--HNLSGYSSPEYS 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	7/18 (39%)
		LRR_8	83..142	CDD:290566	17/58 (29%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	76/418 (18%)
		LRR_8	132..190	CDD:290566	20/70 (29%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..179	CDD:275380	11/22 (50%)
		leucine-rich repeat	180..204	CDD:275380	7/46 (15%)
		LRR_8	203..263	CDD:290566	13/62 (21%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	4/25 (16%)
		LRR_8	252..308	CDD:290566	17/105 (16%)
		leucine-rich repeat	253..276	CDD:275380	8/38 (21%)
		leucine-rich repeat	277..300	CDD:275380	7/48 (15%)
		leucine-rich repeat	301..322	CDD:275380	6/39 (15%)
		LRR_8	325..384	CDD:290566	13/98 (13%)
		leucine-rich repeat	326..350	CDD:275380	8/63 (13%)
		leucine-rich repeat	351..373	CDD:275380	3/21 (14%)
elfn1b	XP_001920383.1	leucine-rich repeat	82..102	CDD:275378	7/19 (37%)
		LRR_8	102..161	CDD:316378	17/58 (29%)
		leucine-rich repeat	103..126	CDD:275378	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275378	6/22 (27%)
		leucine-rich repeat	151..174	CDD:275378	5/22 (23%)
		leucine-rich repeat	175..188	CDD:275378	6/12 (50%)
		PCC	179..>247	CDD:188093	17/67 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100