DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trn and LRRC70

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_852607.3	Gene:	LRRC70 / 100130733	HGNCID:	35155	Length:	622	Species:	Homo sapiens

Alignment Length:	429	Identity:	128/429 - (29%)
Similarity:	197/429 - (45%)	Gaps:	52/429 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVGIWCILASIGVEPAAGLANCPPGCQ-CDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIK 72
            |:.:.|.|..:..:...|   |...|| |....  :.|....|..:|.....|...|.:..|.|.
Human    14 FLVVTCYLLLLLHKEILG---CSSVCQLCTGRQ--INCRNLGLSSIPKNFPESTVFLYLTGNNIS 73

  Fly    73 TIDSSIQFYAELT--------FLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGL 129
            .|:.|     |||        :|| :||.|...| :.|...:.|..:.||:|.|.::....|.||
Human    74 YINES-----ELTGLHSLVALYLD-NSNILYVYP-KAFVQLRHLYFLFLNNNFIKRLDPGIFKGL 131

  Fly   130 SAVTVLNLRGNQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVP 194
            ..:..|.|:.||:|.:.:|.|..|:.::.|||..||:..|....|.|:..||||.|.:|.:..:.
Human   132 LNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRIS 196

  Fly   195 DPVIFQAMPSLAELFLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGLQELRILDLS 259
            :.. ||.:.:||.|:||.|.|..:.::||:.||.|.||.|....:..|...:|.||..|..|.|.
Human   197 ESG-FQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLK 260

  Fly   260 DNRLDRIPSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNG 324
            ::|:..:...|.|.:..|:.|.|..||.|.::...|..||.|..|::: ..|:..:....|.:.|
Human   261 NSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLD-RNRIISIDNDTFENMG 324

  Fly   325 -NLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTLDLSENPLSCDC 388
             :|:.||||.|. |..:....|..||.|.|  |:||:                     ||..|:|
Human   325 ASLKILNLSFNN-LTALHPRVLKPLSSLIH--LQANS---------------------NPWECNC 365

  Fly   389 RVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLN 427
            :::.|.:.|    ||......:.|:.|..:||.:||::|
Human   366 KLLGLRDWL----ASSAITLNIYCQNPPSMRGRALRYIN 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	5/17 (29%)
		LRR_8	83..142	CDD:290566	21/66 (32%)
		leucine-rich repeat	84..107	CDD:275380	9/30 (30%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_RI	129..421	CDD:238064	90/292 (31%)
		LRR_8	132..190	CDD:290566	22/57 (39%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	22/59 (37%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..308	CDD:290566	17/55 (31%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..322	CDD:275380	4/20 (20%)
		LRR_8	325..384	CDD:290566	16/58 (28%)
		leucine-rich repeat	326..350	CDD:275380	9/23 (39%)
		leucine-rich repeat	351..373	CDD:275380	5/21 (24%)
LRRC70	NP_852607.3	LRRNT	31..62	CDD:214470	8/35 (23%)
		LRR 1	61..82		8/25 (32%)
		leucine-rich repeat	65..85	CDD:275380	8/24 (33%)
		LRR_8	85..144	CDD:290566	18/60 (30%)
		LRR 2	85..106		7/22 (32%)
		leucine-rich repeat	86..109	CDD:275380	7/24 (29%)
		LRR 3	109..130		6/20 (30%)
		leucine-rich repeat	110..133	CDD:275380	8/22 (36%)
		LRR_8	133..192	CDD:290566	22/58 (38%)
		LRR 4	133..154		7/20 (35%)
		leucine-rich repeat	134..157	CDD:275380	8/22 (36%)
		LRR 5	157..178		7/20 (35%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		LRR_RI	<159..340	CDD:238064	62/183 (34%)
		LRR 6	181..202		7/21 (33%)
		LRR_8	182..240	CDD:290566	23/58 (40%)
		leucine-rich repeat	182..205	CDD:275380	8/23 (35%)
		LRR 7	205..226		9/20 (45%)
		leucine-rich repeat	206..229	CDD:275380	10/22 (45%)
		LRR_8	228..288	CDD:290566	19/59 (32%)
		LRR 8	229..250		6/20 (30%)
		leucine-rich repeat	230..253	CDD:275380	8/22 (36%)
		LRR 9	253..274		5/20 (25%)
		leucine-rich repeat	254..277	CDD:275380	6/22 (27%)
		LRR_8	277..337	CDD:290566	20/61 (33%)
		LRR 10	277..298		7/20 (35%)
		leucine-rich repeat	278..301	CDD:275380	8/22 (36%)
		LRR 11	301..322		4/21 (19%)
		leucine-rich repeat	302..326	CDD:275380	5/24 (21%)
		LRR 12	326..347		8/21 (38%)
		leucine-rich repeat	327..348	CDD:275380	8/21 (38%)
		LRRCT	359..398	CDD:214507	13/42 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870