DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trn and lingo4a

DIOPT Version :9

Sequence 1:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001076447.1	Gene:	lingo4a / 100005227	ZFINID:	ZDB-GENE-060503-275	Length:	618	Species:	Danio rerio

Alignment Length:	386	Identity:	113/386 - (29%)
Similarity:	171/386 - (44%)	Gaps:	37/386 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WCILA-SIGVEPAAGLANCPPGCQCDDNTLVVQCGEGQLDVLPIALNPSIQRLVIKSNKIKTIDS 76
            |.:|. .:||   |....|...|.|.....:|.|...||..:|..:..:.|.|.:..|.:||: |
Zfish    27 WVVLQWVVGV---ATSGPCAQRCDCSPKLPLVDCSSQQLSAVPEGVPDATQVLNLTYNHLKTL-S 87

  Fly    77 SIQFYA--ELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRG 139
            |.||::  :|..||||:|.|..|....|...:.|..:.|:.|::..|....|.||..|..|::..
Zfish    88 SRQFFSLRQLRELDLSANMLTVIEVEAFVGLQNLITLRLSRNRLKIIPVGAFSGLPNVQFLDISE 152

  Fly   140 NQISELHQGTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPS 204
            |:|..|....|..:..:::|...||.:.::..:||.||..|..|.|:...|||||... |..:..
Zfish   153 NEILVLLDDMFGEMPSLQKLEASENDLVFISNRAFSGLPNLLELRLERCNLTTVPSEA-FSRLTG 216

  Fly   205 LAELFLGMNTLQSIQADAFQDLKGLTRLELKGAS-LRNISHDSFLGLQELRILDLSDNRLDRIPS 268
            |..|......|.::..::|:.|:.|..|.:.... |..::.:|.:|| .|..|.||...|..:|.
Zfish   217 LQHLRFCRLGLTALPNNSFRQLQRLQDLHVSRCPWLHTLAVNSLIGL-NLTSLTLSHCNLSAVPY 280

  Fly   269 VGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSDNGNLEYLNLSS 333
            ..|..||.|..|.|..|....:..|....|.:|:.|.:        |.||
Zfish   281 APLHHLVYLRYLDLSYNPITTVLSGLLGDLLRLQELHL--------VSTG--------------- 322

  Fly   334 NKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLF-PWKDLQTLDLSENPLSCDCRVMWL 393
               ||.|:.||...|:..:.:.:..|.|.:|.|..| ....|:.|.|..|||:||||::|:
Zfish   323 ---LLHVESGAFRNLAFFRLLNVSDNRLVTLEESAFHAVGSLEVLRLDGNPLACDCRLLWV 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	7/17 (41%)
		LRR_8	83..142	CDD:290566	19/58 (33%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_RI	129..421	CDD:238064	76/267 (28%)
		LRR_8	132..190	CDD:290566	16/57 (28%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..204	CDD:275380	9/23 (39%)
		LRR_8	203..263	CDD:290566	15/60 (25%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	6/23 (26%)
		LRR_8	252..308	CDD:290566	17/55 (31%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		LRR_8	325..384	CDD:290566	15/59 (25%)
		leucine-rich repeat	326..350	CDD:275380	6/23 (26%)
		leucine-rich repeat	351..373	CDD:275380	5/22 (23%)
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	8/28 (29%)
		leucine-rich repeat	52..72	CDD:275380	5/19 (26%)
		leucine-rich repeat	73..96	CDD:275380	9/23 (39%)
		LRR_RI	88..380	CDD:238064	93/319 (29%)
		LRR_8	95..155	CDD:290566	19/59 (32%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		LRR_8	191..250	CDD:290566	16/59 (27%)
		leucine-rich repeat	193..216	CDD:275380	9/23 (39%)
		leucine-rich repeat	217..240	CDD:275380	5/22 (23%)
		leucine-rich repeat	241..288	CDD:275380	14/47 (30%)
		LRR_8	264..323	CDD:290566	20/84 (24%)
		leucine-rich repeat	289..310	CDD:275380	5/20 (25%)
		LRR_8	312..371	CDD:290566	20/84 (24%)
		leucine-rich repeat	313..336	CDD:275380	11/48 (23%)
		leucine-rich repeat	337..356	CDD:275380	4/18 (22%)
		I-set	428..512	CDD:254352
		Ig	439..512	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010