DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LDLR and arr

DIOPT Version :9

Sequence 1:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	136/458 - (29%)
Similarity:	219/458 - (47%)	Gaps:	83/458 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   288 ECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVC----NDLKIGYECLCPDGFQLVA 348
            |.|...|..|   ..|.| |..::....|.|..|||.|||:|    |..  |:.|.||.|.:|::
  Fly   335 ELIDTPKAPN---SVRAW-DPSLQPYEDNPCAHNNGNCSHLCLLATNSQ--GFSCACPTGVKLIS 393

Human   349 QRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMT 413
            ...|                                         |.||...:|...|.::.|::
  Fly   394 ANTC-----------------------------------------ANGSQEMMFIVQRTQISKIS 417

Human   414 LDRSEYTSLIP----NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAH----GVSSYDTVIS 470
            ||..:|| :.|    .::..:|:|.:.....|||||:.     :..:.|||    ||:.:   ::
  Fly   418 LDSPDYT-IFPLPLGKVKYAIAIDYDPVEEHIYWSDVE-----TYTIKRAHADGTGVTDF---VT 473

Human   471 RDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTD 535
            .:::.|||||:||:..|:||||:|...:.|....|..||.|..|:..:||||.|.|..|:|:|:|
  Fly   474 SEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVAPSLGWMFWSD 538

Human   536 WG-TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTIL 599
            |. ...|:::..|:|.:...||:||:.|||||.||:.:..:||.|.|...|...:::|..|:.::
  Fly   539 WNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVANMDGSGRRVVI 603

Human   600 EDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVL-FHNLTQPRG 663
            .|  .|.|.|.|::.:|.::|||....:|..|:::||::..::.:..  |:.|.| ...|.:.||
  Fly   604 SD--NLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQY--PDLMGLKVTRLREVRG 664

Human   664 VNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVR 728
            .|.|   .:.||||.:|||..|:      .:.|.|.....||.|.|:|:..|...:.:::....|
  Fly   665 QNAC---AVRNGGCSHLCLNRPR------DYVCRCAIDYELANDKRTCVVPAAFLLFSRQEHIGR 720

Human   729 LKV 731
            :.:
  Fly   721 ISI 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486
		Ldl_recept_a	66..104	CDD:278486
		Ldl_recept_a	107..143	CDD:278486
		Ldl_recept_a	147..179	CDD:278486
		Ldl_recept_a	195..231	CDD:278486
		Ldl_recept_a	235..270	CDD:278486
		LDLa	278..308	CDD:294076	6/19 (32%)
		FXa_inhibition	318..>346	CDD:291342	14/31 (45%)
		EGF_CA	354..388	CDD:214542	0/33 (0%)
		LDL-receptor class B 1	397..438		11/44 (25%)
		LY	419..457	CDD:214531	10/41 (24%)
		LDL-receptor class B 2	439..485		17/49 (35%)
		Ldl_recept_b	439..482	CDD:278487	15/46 (33%)
		LDL-receptor class B 3	486..528		18/41 (44%)
		Ldl_recept_b	487..525	CDD:278487	16/37 (43%)
		LDL-receptor class B 4	529..572		19/43 (44%)
		Ldl_recept_b	529..569	CDD:278487	17/40 (43%)
		LY	553..595	CDD:214531	17/41 (41%)
		LDL-receptor class B 5	573..615		12/41 (29%)
		LDL-receptor class B 6	616..658		11/42 (26%)
		Ldl_recept_b	616..655	CDD:278487	11/39 (28%)
		FXa_inhibition	671..711	CDD:291342	14/39 (36%)
		Clustered O-linked oligosaccharides	721..768		1/11 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828
arr	NP_524737.2	LY	162..201	CDD:214531
		NHL	168..503	CDD:302697	60/223 (27%)
		NHL repeat	172..237	CDD:271320
		LY	252..293	CDD:214531
		NHL repeat	261..298	CDD:271320
		NHL repeat	303..339	CDD:271320	2/3 (67%)
		NHL repeat	341..419	CDD:271320	28/124 (23%)
		NHL repeat	428..476	CDD:271320	12/55 (22%)
		LY	472..511	CDD:214531	15/38 (39%)
		NHL repeat	477..503	CDD:271320	13/25 (52%)
		Ldl_recept_b	534..573	CDD:278487	16/38 (42%)
		LY	558..599	CDD:214531	17/40 (43%)
		LY	600..641	CDD:214531	13/42 (31%)
		FXa_inhibition	668..703	CDD:291342	15/43 (35%)
		LY	739..773	CDD:214531
		LY	776..818	CDD:214531
		LY	819..860	CDD:214531
		FXa_inhibition	973..1010	CDD:291342
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740