DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LDLR and CG32432

DIOPT Version :9

Sequence 1:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster

Alignment Length:	438	Identity:	87/438 - (19%)
Similarity:	150/438 - (34%)	Gaps:	129/438 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   271 VNVTLCEGPN-------KFKCHSGECITLDKVCNMARDCRDWSDEP----------IKECGTNEC 318
            ||:.|..|.:       :|.|.:|.|:.|.|.||...||.|.||||          ..:.|....
  Fly   201 VNLQLAPGSSSTGCSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYA 265

Human   319 LDNNGGCSHVCNDLKIGYECL---------------------------------CPDGFQLVAQR 350
            |:     .|.....::.:.|:                                 ||||:..:|:.
  Fly   266 LE-----LHRPKQDRVPFVCVLTFTAAGGQHGDVVQVTLDSFTIGRFTSYVHEGCPDGYMQIAES 325

Human   351 RCEDIDECQDPDTCSQLCVNLEGGYKCQCEEG---FQLDPHTKACKAVGSIAYLFFTNRHEVRKM 412
            ....|                 ||..|....|   |..:..:           |.||.|  :.::
  Fly   326 ARTPI-----------------GGMWCGSSWGPVLFYSETRS-----------LIFTIR--LNRL 360

Human   413 TLDRSEYTSLIPNLRNVVALDTEVAS-NRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAP 476
            ..|:|.|.........|::.|:.|.. ..|..::|:|....|:.|::............:..|..
  Fly   361 ARDQSGYNFDFRIRYKVLSRDSSVTRYGGIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQGA 425

Human   477 DGLAVDWIHSNI-----YWTDSVLGTVSVADTK---GVKRKTLFR--ENGSKPRAIVVDPVHG-- 529
            .|:..|:.:|::     |..|..|.: :.|:.|   ....|:|.:  :|.::|:..:.|.:.|
  Fly   426 PGILEDFTNSSVARSDRYGQDFSLFS-AYANNKTFMASLEKSLAKDEQNYTEPKYYLGDLIPGTY 489

Human   530 -FMYWTDWG-TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNG 592
             ...::|.. .|.:::.....|:           :|..:|. ..:.|.:.|....|::..:....
  Fly   490 CSRIFSDCDKKPCRLQSPNFPGI-----------YPRNLTC-YYAVRQHDVPHGKHALILVKQPK 542

Human   593 GNRKTILEDE----KRLAHPFSLAVFEDKVF------WT--DIINEAI 628
            ||...|...|    .::|.|.| |..:||.|      |.  |.|.|.:
  Fly   543 GNLVWISTQETAAANKMAPPPS-ASDKDKKFEPRLKTWNYCDYIQENV 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486
		Ldl_recept_a	66..104	CDD:278486
		Ldl_recept_a	107..143	CDD:278486
		Ldl_recept_a	147..179	CDD:278486
		Ldl_recept_a	195..231	CDD:278486
		Ldl_recept_a	235..270	CDD:278486
		LDLa	278..308	CDD:294076	13/36 (36%)
		FXa_inhibition	318..>346	CDD:291342	7/60 (12%)
		EGF_CA	354..388	CDD:214542	6/36 (17%)
		LDL-receptor class B 1	397..438		10/40 (25%)
		LY	419..457	CDD:214531	8/38 (21%)
		LDL-receptor class B 2	439..485		8/45 (18%)
		Ldl_recept_b	439..482	CDD:278487	7/42 (17%)
		LDL-receptor class B 3	486..528		11/51 (22%)
		Ldl_recept_b	487..525	CDD:278487	9/47 (19%)
		LDL-receptor class B 4	529..572		6/46 (13%)
		Ldl_recept_b	529..569	CDD:278487	6/43 (14%)
		LY	553..595	CDD:214531	6/41 (15%)
		LDL-receptor class B 5	573..615		11/45 (24%)
		LDL-receptor class B 6	616..658		7/21 (33%)
		Ldl_recept_b	616..655	CDD:278487	7/21 (33%)
		FXa_inhibition	671..711	CDD:291342
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	12/30 (40%)
		CUB	503..646	CDD:238001	21/100 (21%)
		LDLa	1203..1231	CDD:197566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900