DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LDLR and frac

DIOPT Version :10

Sequence 1:NP_000518.1 Gene:LDLR / 3949 HGNCID:6547 Length:860 Species:Homo sapiens
Sequence 2:NP_648137.3 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster


Alignment Length:941 Identity:184/941 - (19%)
Similarity:276/941 - (29%) Gaps:374/941 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    27 CER--NEFQ--CQDG--------KCISYKWV--------CDGSAECQDGS--------------- 56
            ||.  .|::  ||:|        .|:.....        |.|:.|...||               
  Fly   307 CENLPGEYKCSCQEGYYLDESGKSCVDINECANPELSSNCQGACENLPGSYRCVEPLEENPEITE 371

Human    57 ------DESQETCLSV--------TCKSG-DFSCGGR----VNRCIPQFWRCDGQVDCDNGSDEQ 102
                  :::.|..::|        ||.|| ..|..|.    :|.|     ..||..|.||.:   
  Fly   372 VVENPIEKTNEVPVNVSESQPAGKTCNSGFQLSADGTDCQDINEC-----EVDGPEDLDNNA--- 428

Human   103 GCPPKTCSQ------DEFRCHDGKCISRQFVCDSDRDC-LDGSDEASCPVLT---CG-------P 150
                 .|.|      ..|||   .|:....:.:..|.| ||...:...|.|.   |.       .
  Fly   429 -----VCQQKCENTIGSFRC---TCVEGYHLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLPE 485

Human   151 ASFQC----------NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL 205
            .|::|          :..:|:.|...|..:...|..|   |..|..       |...::|...|.
  Fly   486 GSYRCVCPKGYELSEDQHSCLVQESPCSTEKGVEKCS---PGTCLA-------SEDNTSFSCICP 540

Human   206 SG------------ECIHSSWRCD-------GGPDCK----------------------DKSDEE 229
            :|            ||...:..|.       ||..|:                      :...|:
  Fly   541 TGYRSEAFSCQDIDECAEDTHLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAENLCEVNNNGCEQ 605

Human   230 NC-----AVATCRP--------------DEFQCSDGNC------IHGSRQC-------------D 256
            .|     .|..||.              ||...::|.|      :.||..|             .
  Fly   606 ICLTARGGVCACREGFRLSADGKSCEDVDECLVNNGGCQQVCRNLPGSYGCICAAGYELLKLDGI 670

Human   257 REYDCKDMSDEV-----GCVNVTLCE---GPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKEC 313
            |.| |.|: ||.     ||.:..|||   |.....|..|..:.||.....:.:....:|....|.
  Fly   671 RGY-CFDI-DECSQRTHGCSDQMLCENLNGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSET 733

Human   314 -GTNECLD------NNGGCSHVCNDLKIGYECLCPDGFQLVA-QRRCEDIDECQDPD-TCSQLCV 369
             ..:.|||      .||.|||.|.:...|::|.||.|:.|.. .|.|:|||||.|.: .|||||:
  Fly   734 PSAHTCLDIDECSLANGNCSHFCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLCL 798

Human   370 NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDT 434
            |..||:.|.||.||:|.|....|.              ::.:.:.|....:.:..||....|   
  Fly   799 NQPGGFACACETGFELTPDGFGCA--------------DIDECSQDYGNCSDICINLLGTHA--- 846

Human   435 EVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVS 499
             .|..|.|  :|::..:....:|...|:.|            .|.:.:.|:.        .||..
  Fly   847 -CACERGY--ELAKDKLSCLDVDECAGLLS------------GGCSHECINK--------AGTFE 888

Human   500 VADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPN 564
            .....|.    :..::|......:|....|.....|...|.:...|       |:|         
  Fly   889 CGCPLGY----ILNDDGRSCSPALVGCPPGTQRSADGCAPIECNPG-------YTL--------- 933

Human   565 GITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF 629
                                       |.:.|.:..||                           
  Fly   934 ---------------------------GSDDKCVDIDE--------------------------- 944

Human   630 SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKF 694
                                                 |::   .||||.:.|      :.....|
  Fly   945 -------------------------------------CQK---QNGGCSHRC------SNTEGSF 963

Human   695 TCACPDGMLLARDMRSC--LTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRP-VPDTSRLPGAT 756
            .|:||.|..|..|.::|  :.|.:....:..|.|...::.............| :|..|.||.: 
  Fly   964 KCSCPPGYELDSDQKTCQDIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEIPTASSLPES- 1027

Human   757 PGLTTVEIVTMSHQALGDVAGR--GNEKKPS 785
               ..:|:.|..:....:::..  .|.|||:
  Fly  1028 ---PKIELKTPKYPDFTELSNEIPENPKKPA 1055

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:395011 12/71 (17%)
Ldl_recept_a 66..104 CDD:395011 14/50 (28%)
Ldl_recept_a 107..143 CDD:395011 10/42 (24%)
Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515 146..233 23/152 (15%)
Ldl_recept_a 147..179 CDD:395011 8/51 (16%)
Ldl_recept_a 195..231 CDD:395011 10/76 (13%)
Ldl_recept_a 235..270 CDD:395011 15/72 (21%)
Ldl_recept_a 278..308 CDD:395011 5/29 (17%)
FXa_inhibition 318..>346 CDD:464251 14/33 (42%)
EGF_CA 354..388 CDD:214542 20/34 (59%)
LDL-receptor class B 1 397..438 4/40 (10%)
LY 419..457 CDD:214531 7/37 (19%)
LDL-receptor class B 2 439..485 7/45 (16%)
Ldl_recept_b 439..483 CDD:459654 7/43 (16%)
LDL-receptor class B 3 486..528 5/41 (12%)
Ldl_recept_b 487..526 CDD:459654 5/38 (13%)
LDL-receptor class B 4 529..572 6/42 (14%)
Ldl_recept_b 529..569 CDD:459654 6/39 (15%)
LY 553..595 CDD:214531 3/41 (7%)
LDL-receptor class B 5 573..615 4/41 (10%)
LDL-receptor class B 6 616..658 0/41 (0%)
Ldl_recept_b 616..656 CDD:459654 0/39 (0%)
FXa_inhibition 671..711 CDD:464251 12/39 (31%)
Clustered O-linked oligosaccharides 721..768 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..755 5/21 (24%)
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 811..860
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 823..828
fracNP_648137.3 FXa_inhibition 296..331 CDD:464251 6/23 (26%)
cEGF 396..415 CDD:463661 6/18 (33%)
FXa_inhibition 425..458 CDD:464251 9/43 (21%)
FXa_inhibition 476..505 CDD:464251 3/28 (11%)
EGF_CA 552..>581 CDD:214542 6/28 (21%)
FXa_inhibition 596..630 CDD:464251 5/33 (15%)
FXa_inhibition 636..>664 CDD:464251 5/27 (19%)
EGF_CA 676..711 CDD:214542 11/35 (31%)
FXa_inhibition 745..780 CDD:464251 13/34 (38%)
FXa_inhibition 786..821 CDD:464251 17/34 (50%)
vWFA <821..861 CDD:469594 9/59 (15%)
FXa_inhibition 874..904 CDD:464251 6/41 (15%)
FXa_inhibition 945..980 CDD:464251 13/43 (30%)
PTZ00449 <1017..>1098 CDD:185628 10/43 (23%)
CCP 1110..1170 CDD:153056
CCP 1183..1235 CDD:153056
HYR 1468..1536 CDD:460572
Blue background indicates that the domain is not in the aligned region.

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