| Sequence 1: | NP_000518.1 | Gene: | LDLR / 3949 | HGNCID: | 6547 | Length: | 860 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001025454.1 | Gene: | ldlra / 387529 | ZFINID: | ZDB-GENE-031217-1 | Length: | 911 | Species: | Danio rerio |
| Alignment Length: | 937 | Identity: | 484/937 - (51%) |
|---|---|---|---|
| Similarity: | 604/937 - (64%) | Gaps: | 166/937 - (17%) |
- Green bases have known domain annotations that are detailed below.
|
Human 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDG 91
Human 92 QVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCN 156
Human 157 SSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPD 221
Human 222 CKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHS 286
Human 287 GECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRR 351
Human 352 CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDR 416
Human 417 SEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAV 481
Human 482 DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGG 546
Human 547 LNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611
Human 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGG 676
Human 677 CQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQ-- 739
Human 740 -HTTTRPV-PDTSR---LPGATPGL----------------TTVEIVTMSHQALGDVAGRGNEKK 783
Human 784 PSSVRALSIVLPIVLLV------------------------------------------------ 800
Human 801 ---------------------------------------FLCL---GVFLLWKNWRLKNINSINF 823
Human 824 DNPVYQKTTEDEVHICHN--QDGYSYP 848 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LDLR | NP_000518.1 | Ldl_recept_a | 25..58 | CDD:278486 | 14/30 (47%) |
| Ldl_recept_a | 66..104 | CDD:278486 | 21/37 (57%) | ||
| Ldl_recept_a | 107..143 | CDD:278486 | 18/35 (51%) | ||
| Ldl_recept_a | 147..179 | CDD:278486 | 18/31 (58%) | ||
| Ldl_recept_a | 195..231 | CDD:278486 | 24/35 (69%) | ||
| Ldl_recept_a | 235..270 | CDD:278486 | 28/34 (82%) | ||
| LDLa | 278..308 | CDD:294076 | 20/29 (69%) | ||
| FXa_inhibition | 318..>346 | CDD:291342 | 24/27 (89%) | ||
| EGF_CA | 354..388 | CDD:214542 | 23/33 (70%) | ||
| LDL-receptor class B 1 | 397..438 | 31/40 (78%) | |||
| LY | 419..457 | CDD:214531 | 19/37 (51%) | ||
| LDL-receptor class B 2 | 439..485 | 7/45 (16%) | |||
| Ldl_recept_b | 439..482 | CDD:278487 | 7/42 (17%) | ||
| LDL-receptor class B 3 | 486..528 | 24/41 (59%) | |||
| Ldl_recept_b | 487..525 | CDD:278487 | 21/37 (57%) | ||
| LDL-receptor class B 4 | 529..572 | 31/42 (74%) | |||
| Ldl_recept_b | 529..569 | CDD:278487 | 28/39 (72%) | ||
| LY | 553..595 | CDD:214531 | 28/41 (68%) | ||
| LDL-receptor class B 5 | 573..615 | 25/41 (61%) | |||
| LDL-receptor class B 6 | 616..658 | 27/41 (66%) | |||
| Ldl_recept_b | 616..655 | CDD:278487 | 24/38 (63%) | ||
| FXa_inhibition | 671..711 | CDD:291342 | 28/39 (72%) | ||
| Clustered O-linked oligosaccharides | 721..768 | 17/69 (25%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 734..755 | 10/27 (37%) | |||
| Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 | 811..860 | 28/40 (70%) | |||
| NPXY motif. /evidence=ECO:0000269|PubMed:22509010 | 823..828 | 4/4 (100%) | |||
| ldlra | NP_001025454.1 | LDLa | 23..55 | CDD:197566 | 14/30 (47%) |
| Ldl_recept_a | 63..101 | CDD:365841 | 21/37 (57%) | ||
| LDLa | 106..140 | CDD:238060 | 18/33 (55%) | ||
| LDLa | 144..176 | CDD:197566 | 18/31 (58%) | ||
| Ldl_recept_a | 192..227 | CDD:365841 | 24/34 (71%) | ||
| Ldl_recept_a | 231..266 | CDD:365841 | 28/34 (82%) | ||
| LDLa | 274..304 | CDD:238060 | 20/29 (69%) | ||
| FXa_inhibition | 314..348 | CDD:373209 | 27/33 (82%) | ||
| EGF_CA | 350..380 | CDD:214542 | 21/29 (72%) | ||
| Ldl_recept_b | 437..481 | CDD:278487 | 28/83 (34%) | ||
| Ldl_recept_b | 485..525 | CDD:278487 | 28/39 (72%) | ||
| LY | 510..551 | CDD:214531 | 28/40 (70%) | ||
| Ldl_recept_b | 572..611 | CDD:278487 | 24/38 (63%) | ||
| FXa_inhibition | 623..664 | CDD:373209 | 29/43 (67%) | ||
| PHA03247 | <666..808 | CDD:223021 | 29/144 (20%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 77 | 1.000 | Domainoid score | I30398 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H55469 | |
| Inparanoid | 1 | 1.050 | 987 | 1.000 | Inparanoid score | I2378 |
| NCBI | 1 | 1.000 | - | - | ||
| OMA | 1 | 1.010 | - | - | QHG49125 | |
| OrthoDB | 1 | 1.010 | - | - | D179614at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0002088 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 1 | 0.900 | - | - | OOG6_103130 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR24270 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R7933 |
| SonicParanoid | 1 | 1.000 | - | - | X1052 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| ZFIN | 1 | 1.500 | - | - | ||
| 17 | 17.370 | |||||