DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LDLR and cue

DIOPT Version :9

Sequence 1:	NP_000518.1	Gene:	LDLR / 3949	HGNCID:	6547	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_612113.2	Gene:	cue / 38174	FlyBaseID:	FBgn0011204	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	84/381 - (22%)
Similarity:	154/381 - (40%)	Gaps:	89/381 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   393 KAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQR--MICSTQ 455
            :.:.:.|:.|    .|:..:|.|.||                    ..||::||..|  .|.|.:
  Fly    49 QTIATAAHEF----DELSALTFDESE--------------------ELIYFNDLKHRNGSIFSLK 89

Human   456 LD--RAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRE---N 515
            .|  .|:.|:. .|:.....::..|||.|.::.|::|:|:....:..|...|.....:..:   .
  Fly    90 RDLIAANHVAE-QTIARTGNESVGGLAYDPLNMNLFWSDTEQRKIFFAPIHGSATPQVLVDLSAE 153

Human   516 GSKPRAIVVDPVHGFMYWTDWG-TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVD 579
            |.:|..:.||.....:|||:.. |...:::..|:|.:...:::.||..|.||.:|.||.||:|:|
  Fly   154 GGRPDGVAVDVCRRKLYWTNSNVTHPTVERINLDGSNRTVIISSNIDMPRGIVVDQLSDRLFWID 218

Human   580 ---SKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNL 641
               ....|:.|..::|.:|:.:|:|:..  .|.:|||..|.::|||....|::|..::....|..
  Fly   219 DLKGVFFSVESSKLDGSDRQVVLKDKHH--EPLNLAVTNDAIYWTDRTTRAVWSHPKVPVIKVTT 281

Human   642 LAE----------NLLSPE------DMVLFHNLT-QPRGV----NWCERTTLSNGGCQYLCLPAP 685
            .::          :...||      .:|...||: :.||:    .:.:|....:.....:.....
  Fly   282 TSKPDEEDSTDSTDFKDPEPVAEDCPLVRVANLSEEARGIVARTGFYQRLQKDHHCASIVRKVKE 346

Human   686 QINPHSPKF-----------------------------TCACPDGMLLAR-DMRSC 711
            :::..|.||                             .|.||.|...:| ::|.|
  Fly   347 RVDEQSRKFEIRSLLDQKIKVLEDERCMNDGEYRAATDLCICPTGFKGSRCEIREC 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:278486
		Ldl_recept_a	66..104	CDD:278486
		Ldl_recept_a	107..143	CDD:278486
		Ldl_recept_a	147..179	CDD:278486
		Ldl_recept_a	195..231	CDD:278486
		Ldl_recept_a	235..270	CDD:278486
		LDLa	278..308	CDD:294076
		FXa_inhibition	318..>346	CDD:291342
		EGF_CA	354..388	CDD:214542
		LDL-receptor class B 1	397..438		7/40 (18%)
		LY	419..457	CDD:214531	7/39 (18%)
		LDL-receptor class B 2	439..485		15/49 (31%)
		Ldl_recept_b	439..482	CDD:278487	14/46 (30%)
		LDL-receptor class B 3	486..528		9/44 (20%)
		Ldl_recept_b	487..525	CDD:278487	7/40 (18%)
		LDL-receptor class B 4	529..572		12/43 (28%)
		Ldl_recept_b	529..569	CDD:278487	11/40 (28%)
		LY	553..595	CDD:214531	15/44 (34%)
		LDL-receptor class B 5	573..615		14/44 (32%)
		LDL-receptor class B 6	616..658		10/57 (18%)
		Ldl_recept_b	616..655	CDD:278487	10/54 (19%)
		FXa_inhibition	671..711	CDD:291342	9/69 (13%)
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269\|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269\|PubMed:22509010	823..828
cue	NP_612113.2	LY	101..141	CDD:214531	9/39 (23%)
		Ldl_recept_b	167..208	CDD:278487	11/40 (28%)
		LY	193..237	CDD:214531	15/43 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810