Protein Alignment LDLR and CG6553

DIOPT Version :10

• Sequence 1: NP_000518.1
• Gene: LDLR / 3949
• HGNCID: 6547
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_610911.1
• Gene: CG6553 / 36537
• FlyBaseID: FBgn0033880
• Length: 319
• Species: Drosophila melanogaster
• Alignment Length: 268
• Identity: 74/268 - (27%)
• Similarity: 100/268 - (37%)
• Gaps: 62/268 - (23%)

Human   115 RCHDGKCISRQFVCDSDRDCLDGSDE--ASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGS 177
            ||..|.||....:||...:|||||||  |.|..:.|...:|:|:...||.....||...||.|||
  Fly    35 RCGGGDCIQLDQLCDGSANCLDGSDETVAMCEKVWCPGYAFRCSYGACIASTAVCDGVQDCVDGS 99

Human   178 DEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDE-----ENCAVATCR 237
            ||....||.    |...:.|..:|.:|.||:|:..|..|||..||:|..||     |...:.|..
  Fly   100 DEQGWLCRA----QMQQANCDNWEMYCSSGQCMTYSKLCDGIRDCRDGDDELESLCEGVTIPTTT 160

Human   238 -PDEFQCSDGNCIHG-------SRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDK 294
             ......:..:.||.       :|:..|                     ||..: .:|||:....
  Fly   161 VSSTTSTTTESSIHRITPTVPVTRKASR---------------------PNPLQ-ENGECVVPQL 203

Human   295 VCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED----- 354
            ...|.:...|    .|...|           |.|.|..:|.|:|......:...|..|:|
  Fly   204 PNVMVKHFTD----AILTVG-----------SRVANGTRIYYDCPAEHRLKGENQNICQDALWAR 253

Human   355 -IDECQDP 361
             ...|:.|
  Fly   254 KFPYCETP 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LDLR	NP_000518.1	Ldl_recept_a	25..58	CDD:395011
		Ldl_recept_a	66..104	CDD:395011
		Ldl_recept_a	107..143	CDD:395011	15/29 (52%)
		Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515	146..233		33/91 (36%)
		Ldl_recept_a	147..179	CDD:395011	12/31 (39%)
		Ldl_recept_a	195..231	CDD:395011	16/40 (40%)
		Ldl_recept_a	235..270	CDD:395011	5/42 (12%)
		Ldl_recept_a	278..308	CDD:395011	7/29 (24%)
		FXa_inhibition	318..>346	CDD:464251	6/27 (22%)
		EGF_CA	354..388	CDD:214542	3/14 (21%)
		LDL-receptor class B 1	397..438
		LY	419..457	CDD:214531
		LDL-receptor class B 2	439..485
		Ldl_recept_b	439..483	CDD:459654
		LDL-receptor class B 3	486..528
		Ldl_recept_b	487..526	CDD:459654
		LDL-receptor class B 4	529..572
		Ldl_recept_b	529..569	CDD:459654
		LY	553..595	CDD:214531
		LDL-receptor class B 5	573..615
		LDL-receptor class B 6	616..658
		Ldl_recept_b	616..656	CDD:459654
		FXa_inhibition	671..711	CDD:464251
		Clustered O-linked oligosaccharides	721..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..755
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913	811..860
		NPXY motif. /evidence=ECO:0000269|PubMed:22509010	823..828
CG6553	NP_610911.1	LDLa	34..60	CDD:197566	12/24 (50%)
		LDLa	70..101	CDD:197566	12/30 (40%)
		LDLa	115..146	CDD:197566	13/30 (43%)